DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11771 and PRD1

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_009874.1	Gene:	PRD1 / 850301	SGDID:	S000000562	Length:	712	Species:	Saccharomyces cerevisiae

Alignment Length:	584	Identity:	138/584 - (23%)
Similarity:	250/584 - (42%)	Gaps:	87/584 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 NGLTLDKDKQDGLKELLTHLGRERANF-------KNKVNMAVHSF----GQIITDFNLVRDFPPS 235
            :||.||:..:..:||:...:.....||       |..:.......    ..|:|.|..::
Yeast   169 SGLELDEGNRLKIKEIKKKISVNSINFSKNLGEQKEYITFTKEQLEGVPDSILTQFETIK----- 228

  Fly   236 LLEATARDPGQPMTGPWKITLQPQVVDGFLKHCPERMQRWNVWRASVLKASSQQEKSLENSTHIE 300
                :.:|..:.:   :|:|.:...:...:|.......|...:.|       .|.|..||...:.
Yeast   229 ----SDKDSNETL---YKVTFKYPDIFPVMKLASSAQTRKQAFLA-------DQNKVPENEAILL 279

  Fly   301 KIRGLRKRQANLLGYESFADMSMQTKM-------VGSVDNLKQIFAKLLKFAGPAQSVELEKLQG 358
            ....||...|:||||:::|:.::..||       :..:::||.   ||:    |....||:.||.
Yeast   280 DTLKLRDELASLLGYDTYANYNLYDKMAEDSTTVMNFLNDLKD---KLI----PLGRKELQVLQD 337

  Fly   359 F-AQD-----SGCEYKLEAYDVAYWRRKQLAAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGIK 417
            . |:|     .|.:.....:|..|:..|.|.....:..:|:.|:|||...::|:..:.|.||.:|
Yeast   338 MKAEDVKKLNQGADPNYYIWDHRYYDNKYLLENFNVDLEKISEYFPLEATITGMLEIYETLFNLK 402

  Fly   418 IVE---QPNAEVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHK------FGRNNGWMVGIR 473
            .:|   ..|..|||..||...|::.|...|...||..|.|.:.::.|      ||.::.:|  |.
Yeast   403 FIETKDSQNKSVWHDDVKQIAVWNMDDPKSPNFVGWIYFDLHPRDGKYGHAANFGLSSSFM--ID 465

  Fly   474 NSNKSAGLTPLCALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQHLLTQAGYSDLAGLSNI 538
            ::.:|   .|:.||:.|||  :|...||.||.::::...|...|.|:..|:.|...|...|..::
Yeast   466 DTTRS---YPVTALVCNFS--KSTKDKPSLLKHNEIVTFFHELGHGIHDLVGQNKESRFNGPGSV 525

  Fly   539 EWDASQVSGHVMSNFLDDPTVIRSLSGHFSSGEPLEAELSQKMRLLKTQLAGYNL--CQDLYLAD 601
            .||..:....::..:..:...:.:||.|:.:||.:...|...  |:||:.....|  .:.|:...
Yeast   526 PWDFVEAPSQMLEFWTWNKNELINLSSHYKTGEKIPESLINS--LIKTKHVNGALFTLRQLHFGL 588

  Fly   602 LDVELHRSNAF--------WLEVVRKLWPVYQCMPLDK-KDAHPCSLTDIFAGDWAAAQFSHLYS 657
            .|:::|.....        |.::.:.:..:.....|.| .|    |...|.:..::|..:.:|::
Yeast   589 FDMKVHTCKDLQNLSICDTWNQLRQDISLISNGGTLSKGYD----SFGHIMSDSYSAGYYGYLWA 649

  Fly   658 RLIAADI-SSSFAEQRSEENYAVVGRRYKQTFLSCGGSVPTAEVFRRFQGRDPSAEALLKSLDI 720
            .:.|.|: .:.||:   :...|..|.:|:...|:.||.....:..:.|.||:||.:|.||.|.:
Yeast   650 EVFATDMYHTKFAK---DPLNAKNGIQYRDIVLARGGLYDINDNLKEFLGREPSKDAFLKELGL 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	138/582 (24%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	123/489 (25%)
PRD1	NP_009874.1	M3A_TOP	54..708	CDD:341050	137/580 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1976
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001673
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100561
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2240
SonicParanoid	1	1.000	-	-		X1228
TreeFam	1	0.960	-	-
	9	8.580