DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and THOP1

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_003240.1	Gene:	THOP1 / 7064	HGNCID:	11793	Length:	689	Species:	Homo sapiens

Alignment Length:	693	Identity:	166/693 - (23%)
Similarity:	297/693 - (42%)	Gaps:	99/693 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GLPAFSDITIEMCLGAIG--QQASAVENSVKALESDLHSGKQLNAASIFRELDTVTGPLETTWGV 116
            |...|.|::.|..|.|:.  :....|:.::......:...|.:..||  .|.|......:....:
Human    52 GTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTAS--TEADKKLSEFDVEMSM 114

  Fly   117 AKALYLGNSTLIPTKSYMNIHERARNARAAKFCNQTVYKALKDASSDS-GPDEQRMRQKFLLEGK 180
            .:.:|                             |.:....:....|| .|:..|..::.:..|:
Human   115 REDVY-----------------------------QRIVWLQEKVQKDSLRPEAARYLERLIKLGR 150

  Fly   181 LNGLTLDKDKQDGLKELLTHLGRERANFKNKVNMAVHSFGQIITDFNLVRD--FPPSLLEATARD 243
            .|||.|.::.|:.:|.:           |.|:::....|.:     ||..|  |.|..|:.....
Human   151 RNGLHLPRETQENIKRI-----------KKKLSLLCIDFNK-----NLNEDTTFLPFTLQELGGL 199

  Fly   244 PGQPMT-------GPWKITLQPQVVDGFLKHC--PERMQRWNVWRASVLKASSQQEKSLENSTHI 299
            |...:.       |..|:||:.......||.|  ||.       |..|.:|.:.:.|. ||...:
Human   200 PEDFLNSLEKMEDGKLKVTLKYPHYFPLLKKCHVPET-------RRKVEEAFNCRCKE-ENCAIL 256

  Fly   300 EKIRGLRKRQANLLGYESFADMSMQTKMVGS-------VDNLKQIFAKLLKFAGPAQSVELEKLQ 357
            :::..||.:::.|||:.:.||..::..|..:       :|.|.|   ||.......::|.||..:
Human   257 KELVTLRAQKSRLLGFHTHADYVLEMNMAKTSQTVATFLDELAQ---KLKPLGEQERAVILELKR 318

  Fly   358 GFAQDSGCEY--KLEAYDVAYWRRKQLAAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGIKIVE 420
            ...:..|..:  ::.|:|:.|:..:.....:.:....|:|:||:..|..||..:.::|.|:....
Human   319 AECERRGLPFDGRIRAWDMRYYMNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHH 383

  Fly   421 QPNAEVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHKFGRNN--GWMVGIRNSNKSAGLTP 483
            :..|..||..|:.|...||   .|...||.||:|.|.:|.|:|...  |...|....:.|..:.
Human   384 EEGASAWHEDVRLYTARDA---ASGEVVGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQIA- 444

  Fly   484 LCALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQHLLTQAGYSDLAGLSNIEWDASQVSGH 548
            :.|::.||::| :.|| |.||.:|:::..|..||..:..|.:||.::..:| :::|.|..:....
Human   445 IAAMVANFTKP-TADA-PSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSG-THVERDFVEAPSQ 506

  Fly   549 VMSNFLDDPTVIRSLSGHFSSGEPLEAELSQKM---RLLKTQLAGYNLCQDLYLADLDVELH-RS 609
            ::.|::.:...:..:|.|:.:|..:..||.:|:   |...|.|  :||.| :.||.:|..|| ::
Human   507 MLENWVWEQEPLLRMSRHYRTGSAVPRELLEKLIESRQANTGL--FNLRQ-IVLAKVDQALHTQT 568

  Fly   610 NAFWLEVVRKLWPVYQCMPLDKKDAHPCSLTDIFAGDWAAAQFSHLYSRLIAADISSSFAEQRSE 674
            :|...|...:|......:|.......|.:...: ||.:.|..:.:|:|.:.:.|:..:..:|...
Human   569 DADPAEEYARLCQEILGVPATPGTNMPATFGHL-AGGYDAQYYGYLWSEVYSMDMFHTRFKQEGV 632

  Fly   675 ENYAVVGRRYKQTFLSCGGSVPTAEVFRRFQGRDPSAEALLKS 717
            .| :.||..|:...|..|||...:.:.|||.||||..:|.|.|
Human   633 LN-SKVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLS 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	166/693 (24%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	127/471 (27%)
THOP1	NP_003240.1	M3A_TOP	34..675	CDD:188994	166/693 (24%)
THOP1	NP_003240.1	Dcp	39..679	CDD:223416	166/693 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142162
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1976
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D642479at2759
OrthoFinder	1	1.000	-	-		FOG0001673
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100561
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2240
SonicParanoid	1	1.000	-	-		X1228
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.590