DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and thop1

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	XP_005172875.1	Gene:	thop1 / 436628	ZFINID:	ZDB-GENE-040718-47	Length:	707	Species:	Danio rerio

Alignment Length:	717	Identity:	163/717 - (22%)
Similarity:	296/717 - (41%)	Gaps:	159/717 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LGAIGQQASAVENSVKAL----------------ESDLHSGKQLNAASIFRELDTVTGPLETTWG 115
            :||:...:...||::|||                ...:.|.|.:.:||  .|.|......:....
Zfish    69 VGALDLDSVNYENTLKALADVEVEYTVQRNMLDFPQHVSSSKDVRSAS--TEADKKLSEFDVEMS 131

  Fly   116 VAKALYLGNSTLIPTKSYMNIHERARNARAAKFCNQTVYKALKDASSDSGPDEQRMRQKFLLEGK 180
            :.:.:|         :..:.:.|:                 |.:.|  ..|:.:|..::.:..||
Zfish   132 MREDVY---------QRIVALEEK-----------------LPEGS--LSPEAKRYMERLIKLGK 168

  Fly   181 LNGLTLDKDKQDGLKELLTHLGRERANFKNKVNMAVHSFGQIITDFNLVRD----FPPSLLEATA 241
            .|||.|.|..|:.:|::...|.....:|...:|       :..|..:..|:    .|...|.:..
Zfish   169 RNGLHLPKVTQEEIKKIKKKLSTLCIDFNKHLN-------EDTTCLHFSREELGGLPEDFLNSLE 226

  Fly   242 RDPGQPMTGPWKITLQPQVVDGFLKHC--PERMQRWNVWRASVLKASSQQEKSLENSTHIEKIRG 304
            :|.    :|..|:||:.......:|.|  ||..::        |:.:.......|||..::::..
Zfish   227 KDE----SGKLKLTLKYPHYFPTMKKCFVPETRKK--------LEEAFNSRCKEENSAILKELVN 279

  Fly   305 LRKRQANLLGYESFADMSMQTKMVGS---VDNLKQIFAKLLKFAGPAQSVELEKLQGFAQDSGCE 366
            ||.::::|||:.:.:|..::..|..|   |....:..:..||..|..:...:.||    ::..|:
Zfish   280 LRAQKSSLLGFSTHSDFVLEMNMAKSSKKVSTFLEDLSHKLKPLGEKERAVILKL----KEQECQ 340

  Fly   367 YK-------LEAYDVAYWRRKQLAAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGIKIVEQPNA 424
            .:       |.|:|..|:..:....::.:...:|:|:||:..|..||..:.::|..:...:...|
Zfish   341 KRNLPFTGELYAWDTRYYMTQVEETQYAVDQNQLKEYFPMEVVTKGLLDIYQELLNLTFEQVEGA 405

  Fly   425 EVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHKFGRNNGWMVGIRNSNKSAGLTPLC---- 485
            .|||..|..|.|.|.   :|...||.||:|.:.:|.|:|.           ....||.|.|
Zfish   406 PVWHDDVSLYCVKDR---SSGLVVGQFYLDLFPREGKYGH-----------AACFGLQPGCLLPN 456

  Fly   486 --------ALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQHLLTQAGYSDLAGLSNIEWDA 542
                    |::.|||:| :.|| |.||.:|:::..|..||..:..|..|:.::..:| :::|.|.
Zfish   457 GTRQMAVAAMVANFSKP-TADA-PSLLQHDEVETYFHEFGHVMHQLCAQSDFAMFSG-THVERDF 518

  Fly   543 SQVSGHVMSNFLDDPTVIRSLSGHFSSGEPLEAELSQKMRLLKTQLAG---YNLCQDLYLADLDV 604
            .:....::.|::.:...|:.:|.|:.:|.|:..||..|  |:|::||.   :||.| :.||.:|.
Zfish   519 VEAPSQMLENWVWEKEPIQRMSKHYKTGNPIPEELLDK--LIKSRLANTGLFNLRQ-IVLAKVDQ 580

  Fly   605 ELHRSNAFWLEVVRKLWPVYQCMPLDKKDAHPCSLTDI-----------------FAGDWAAAQF 652
            .||....                 ||..:.:.....||                 .||.:.|..:
Zfish   581 ALHTKTG-----------------LDPAEEYARLCLDILGIPSSPGTNMPATFGHLAGGYDAQYY 628

  Fly   653 SHLYSRLIAADISSSFAEQRSEENY--AVVGRRYKQTFLSCGGSVPTAEVFRRFQGRDPSAEALL 715
            .:|:|.:.:.|:   |..:..:|..  ..||..|:...|..|||...|::.::|.||:|..:|.|
Zfish   629 GYLWSEVFSMDM---FYARFKQEGVMDPKVGLDYRNCILKPGGSEDAADMLKKFLGREPKQDAFL 690

  Fly   716 KS 717
            .|
Zfish   691 LS 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	163/717 (23%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	123/500 (25%)
thop1	XP_005172875.1	Dcp	44..695	CDD:223416	163/717 (23%)
thop1	XP_005172875.1	M3A_TOP	53..693	CDD:188994	163/717 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D642479at2759
OrthoFinder	1	1.000	-	-		FOG0001673
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100561
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2240
SonicParanoid	1	1.000	-	-		X1228
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.640