DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and Frem2

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_001232907.1	Gene:	Frem2 / 310418	RGDID:	1566012	Length:	3158	Species:	Rattus norvegicus

Alignment Length:	656	Identity:	126/656 - (19%)
Similarity:	198/656 - (30%)	Gaps:	257/656 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RAALSAP------LHSTENRPGYIVLVPEIGEEG----PLGEGVLKPDGLPAFSDITIEMCLGAI 70
            ||...||      |...:|:|      |||...|    ..|..||:...|.. ||:..::
  Rat   796 RAGNVAPGTFTLYLQPVDNQP------PEIVNTGFTVEEKGHHVLRETELHV-SDVDTDV----- 848

  Fly    71 GQQASAVENSVKALESDLH-----SGKQLNAASIFRELDTVTG---------------------- 108
                  ...|....::..|     ||:.|:....||..|...|
  Rat   849 ------AHISFTLTQAPKHGHLQISGRPLHVGGQFRLEDIKQGRISYLNSGDESLTDSCSLEVSD 907

  Fly   109 -----PLETTWGVAKALYLGNSTLIPT---KSYMNIHERARNARAAKFCNQTVYKALKDASSDSG 165
                 |:.....|..|...|..:::|.   :||:::.|.......|.....| |:
  Rat   908 RHHVVPITLRVNVRPADREGAMSVLPAGTLESYLDVLENGATEVTANIIKGT-YR---------- 961

  Fly   166 PDEQRMRQKFLLEG-KLNGLTLDKDKQDGLKELLTHLGRERANFKNKVNMA-----VHSFGQI-- 222
             |...:...||||| .|.|            |:|.| |.....|..:..:.     .|:.|:|
  Rat   962 -DTDDLMLTFLLEGPPLYG------------EILVH-GAPAEQFTQRDILEGSVVYAHTSGEIGL 1012

  Fly   223 ---ITDFNLVRDFPPSLLEATARDPGQPMTGPWKITLQPQVVDGFLKHCPERMQRWNVWRASVLK 284
               ...|||      ||         ..|:..|:|  ...|:.|.           .|| .::|.
  Rat  1013 LPKADSFNL------SL---------SAMSQEWRI--GSSVIQGV-----------TVW-VTILP 1048

  Fly   285 ASSQQ--------------EKSLENSTHI--EKIRGLRKRQANLLGYESFADMSMQTKMV----G 329
            ..||.              :|||.:.||:  |.:             :|..|..:.|.::    |
  Rat  1049 VDSQAPEISVGEQFVVLEGDKSLISLTHLSAEDV-------------DSLMDDLLCTIVIQPTSG 1100

  Fly   330 SVDNLKQIFAKLLKFAGPAQSVELEKLQGFAQDSGCEYKLEAYDVAYWRRKQL----AAEHGLQD 390
            .|:|:           .||...|..: .|.|        :.|:.:...|:..:    :...|::.
  Rat  1101 YVENI-----------SPAPGSEKSR-AGIA--------ISAFTLKDLRQGHINYVQSVHRGVEP 1145

  Fly   391 QKLREFFPLPRVLSGLFALSEKLFGIKIV----EQPNAEVWHPAVKFYDVFDADSVNSSTPVGGF 451
            .:.|..|   |...|:.....::|.|.|:    |||  |::   ::.:.|.:..|:...||
  Rat  1146 VEDRFIF---RCSDGINFSERQIFPIVIIPTNDEQP--EMF---MREFMVMEGMSLVVDTP---- 1198

  Fly   452 YVDCYSKEHKFGRNNGWMVGIRNSNKSAGLTPLCALIFNFSEPQSPDAKPPLLGYDDLQML---F 513
                                                |.|.::...|        .|||...   |
  Rat  1199 ------------------------------------ILNAADADIP--------RDDLTFTITRF 1219

  Fly   514 KTFGSGLQHLLTQAGYSDLAGLSNIEWDASQVSGHVMSNFLDDPTVIRSLSGHFSSGEPLEAELS 578
            .|.|..:..|:......:...|..|...:|.:..|..|...:|..||:...|..|         .
  Rat  1220 PTHGHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHS---------V 1275

  Fly   579 QKMRLL 584
            :||.|:
  Rat  1276 EKMALI 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	114/613 (19%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	63/352 (18%)
Frem2	NP_001232907.1	Cadherin_3	374..530	CDD:292802
		Cadherin_3	498..663	CDD:292802
		Cadherin_3	632..795	CDD:292802
		Cadherin_3	761..907	CDD:292802	26/128 (20%)
		Cadherin_3	877..1024	CDD:292802	36/186 (19%)
		Cadherin_3	991..1157	CDD:292802	42/230 (18%)
		Cadherin_3	1123..1271	CDD:292802	35/203 (17%)
		Cadherin_3	1239..1388	CDD:292802	13/52 (25%)
		Cadherin_3	1357..1501	CDD:292802
		Cadherin_3	1469..1610	CDD:292802
		Cadherin_3	1579..1740	CDD:292802
		Calx-beta	1758..1845	CDD:295344
		Calx-beta	1869..1969	CDD:295344
		Calx-beta	1997..2089	CDD:295344
		Calx-beta	2115..2207	CDD:295344
		Calx-beta	2237..2328	CDD:295344
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900