DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and Frem2

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_766450.2	Gene:	Frem2 / 242022	MGIID:	2444465	Length:	3160	Species:	Mus musculus

Alignment Length:	622	Identity:	109/622 - (17%)
Similarity:	209/622 - (33%)	Gaps:	216/622 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 IVLVPEIGEEGPLGEGVLKPDGLPAFSDITIEMCLGAIGQQASAVENSVKALESDL--------- 88
            :|::.::|.  |:.||:.|       .::.:.|.:.|...:.|....|:....|||
Mouse  2070 VVILDDLGR--PILEGIEK-------FELVLRMPMNAALGEPSKATVSINDSASDLPKMQFKERV 2125

  Fly    89 -----HSGKQLNAASIFRELDTVTGPLETTWGVAKALYLGNSTLIPTKSYMNIHERARNARAAKF 148
                 :.|:.:  |.|:|     :|.::....|......|::.::     |:..||...
Mouse  2126 YTCNENDGRVV--AMIYR-----SGDIQHRSSVRCYTRQGSAQVM-----MDFEERPNT------ 2172

  Fly   149 CNQTVYKALKDASSDSG-PDEQRMRQKFLLEGKLNGLTLDKDKQDGLKELLTHLGRERAN----- 207
                      |.|:.:. |.|  |.:..:||      .:|....:.::||...||..:.:
Mouse  2173 ----------DVSTVTFLPGE--MEKPCVLE------LMDDAVYEDVEELRLVLGTPQGSSAFGA 2219

  Fly   208 -----------FKNKVNMAVHSFGQIITDFNLVRDFPPSLLEATARDPGQPMTGPWKITLQPQVV 261
                       .:::.:.||..||:  |.|::.             :|.:|  |...:...|.:.
Mouse  2220 AVGEQNETLIKIQDEADKAVIKFGE--TKFSVT-------------EPSRP--GESVVVKIPVIR 2267

  Fly   262 DGFLKHCPERMQRWNVWRASVLKASSQ-------------------QEKSLENSTHIEKI-RGLR 306
            .|            :..:.|:::..::                   :|...:::..||.| .|:|
Mouse  2268 QG------------DTSKVSIVRVHTKDGSATSGEDYHPVSEEIEFKEGETQHTVEIEVIFDGVR 2320

  Fly   307 K-RQANLLGYESFADMSMQTKMVGSVDNLKQI-------------FAKLLKFAGPAQSVELEKLQ 357
            : |:|..:..:...:|..:|:...::..:::|             ...||.:..|::..|
Mouse  2321 EMREAFTVHLKPDENMVAETQATKAIVYIEEIHSMADVTFPSVPHIVSLLIYDDPSKGRE----- 2380

  Fly   358 GFAQDSG------------CEYKLEAYDVAYWRRKQLAAEHGLQDQKLREFF------------- 397
                |:|            |..|...|:    :...:.|...:.|...|..:
Mouse  2381 ----DTGPVSGYPVVCITACNPKYPDYE----KTGSICASENINDTLTRYRWLISAPAGPDGVTS 2437

  Fly   398 PLPRVLSGLFALSEKLFGI-KIVEQPNAEVWHPAVKFYDVFDADSVNSSTPVGGFYVDCYSKEHK 461
            |:..|....|..|.|:..: .|..||.:.|         ...|.:||::   |...::..|....
Mouse  2438 PMREVDFDTFFTSSKMITLDSIYFQPGSRV---------QCAARAVNTN---GNEGLELMSPIVT 2490

  Fly   462 FGRNNGW----MVGIRNSNKSAGLTPLCALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQH 522
            .||..|.    :.|:      .|..|..|.: .::.|:.||       :.:|..|..|    :.|
Mouse  2491 IGREEGLCQPRVPGV------VGAEPFSAKL-RYTGPEDPD-------FANLIKLTVT----MPH 2537

  Fly   523 LLTQAGYSDLAGLSNIEW----DASQVSGHVMSNFLD 555
            :...........|||.|.    |.::|..|..||.||
Mouse  2538 IDGMLPAISTRELSNFELTLSPDGTRVGNHKCSNLLD 2574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	104/606 (17%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	63/360 (18%)
Frem2	NP_766450.2	CSPG 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	312..406
		Cadherin_3	376..532	CDD:292802
		CSPG 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	431..530
		Cadherin_3	500..665	CDD:292802
		CSPG 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	553..664
		Cadherin_3	634..797	CDD:292802
		CSPG 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	689..796
		Cadherin_3	763..909	CDD:292802
		CSPG 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	817..908
		Cadherin_3	879..1026	CDD:292802
		CSPG 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	934..1026
		Cadherin_3	993..1159	CDD:292802
		CSPG 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1055..1157
		Cadherin_3	1125..1273	CDD:292802
		CSPG 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1178..1271
		Cadherin_3	1241..1390	CDD:292802
		CSPG 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1292..1388
		Cadherin_3	1359..1503	CDD:292802
		CSPG 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1409..1501
		Cadherin_3	1471..1612	CDD:292802
		CSPG 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1521..1610
		Cadherin_3	1581..1742	CDD:292802
		CSPG 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01201	1644..1741
		Calx-beta	1760..1847	CDD:295344
		Calx-beta	1871..1971	CDD:295344
		Calx-beta	1999..2091	CDD:295344	6/29 (21%)
		Calx-beta	2117..2209	CDD:295344	20/127 (16%)
		Calx-beta	2239..2330	CDD:295344	19/119 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3130..3160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900