DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and ZK550.3

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_503059.2	Gene:	ZK550.3 / 178501	WormBaseID:	WBGene00013997	Length:	772	Species:	Caenorhabditis elegans

Alignment Length:	735	Identity:	184/735 - (25%)
Similarity:	317/735 - (43%)	Gaps:	86/735 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GYIVLVPEIGEEGPLGE----GVLKPDGLPAFS--------DITIEMC-------------LGAI 70
            ||.|:.|.|.||.....    .:.|.:..|..:        :.|:.|.             |..:
Worm    51 GYYVVFPVIPEETVENNCFMYNIAKNEDWPKLATAEPRELYEGTVRMLMDYGATVMEHMEHLATL 115

  Fly    71 GQQASAVENSVKALESDLHSGKQLNAASIFRELDTVTGPLETTWGVAKALYLGNSTLIPTKSYMN 135
            ..:....||.|:.|.::.:   ::|.|     ..|:...:.|.|...      |..|.....:
Worm   116 PAEERKFENVVEPLLTEEY---EVNFA-----FQTLVLKMLTDWPDC------NRKLFDADLH-- 164

  Fly   136 IHERARNAR--AAKFCN---QTVYKALKDASSDSGPDEQRMRQKFLLEGKLNGLTLDKDKQDGLK 195
             |.:...||  ..|..|   |...|.|.:|.......:.|:.:.:|||.|.:||....||   .:
Worm   165 -HIKIMCARDQMEKLTNKDFQDAIKQLYEAKDGLSEWQSRLLEWYLLEIKASGLDKHDDK---TR 225

  Fly   196 ELLTHLGRERANFKNKVNMAVHSFGQ----IITDFNLVRDFPPSLLEATARDPGQPMTGPWKITL 256
            ::|....:....:::|....|.|...    ::||..:::|.||.:|:..|.|.....:|||:..:
Worm   226 KVLGSWSKFVDEYRSKYITGVMSTNDQQTFVVTDQKVIKDAPPHVLQKLAVDEQNWESGPWRGRM 290

  Fly   257 QPQVVDGFLKHCPERMQRWNVWRASVLKASSQQEKSLENSTHIEKIRGLRKRQANLLGYESFADM 321
            .|..:..|:::|.:|..|...|.....||....: ...||.:||::|...:..|..|||.|.|:.
Worm   291 TPHTIYPFMQYCGDRQLRATAWEKWTSKAGFDHD-FYNNSINIEELRHNNEGLAKTLGYSSVAEH 354

  Fly   322 SMQTKMVGSVDNLKQIFAKLLKFAGPAQSVELEKLQGFAQDSG-CEY---KLEAYDVAYWRRKQL 382
            .:..||..|.:.::.....|.:...|   |.:::::.::..:| ||.   :|:|||:.|..||:.
Worm   355 RLANKMAASPETVRGFINALQRRIRP---VVIDRMESWSAWAGRCELITGELQAYDMPYVCRKEA 416

  Fly   383 AAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGI--KIVEQPNAEVWHPAVKFYDVFDADSVNSS 445
            ...:.:....|...||.......:..:...:|.:  |.:.....|..|..|:.|.|.|.   .|.
Worm   417 EHHYDVNPLDLMNHFPFWPTFQNIMGVIGHIFNLEFKDITDKGLEKAHADVRIYSVGDK---FSG 478

  Fly   446 TPVGGFYVDCYSKEHKFGRNNGWMVGI-RNSNKSAGLTPLCALIFNFSEPQSPDAKPPLLGYDDL 509
            ...|..|:|.|.:::|.|   ||.|.: |..:|..||..:...|.:...|.|..  |.||.:..|
Worm   479 QHYGRLYIDPYDRQNKRG---GWNVMLARPESKERGLDKIVYFIGSAIAPTSNG--PSLLHHQQL 538

  Fly   510 QMLFKTFGSGLQHLLTQAGYSDL----AGLSNIEWDASQVSGHVMSNFLDDPTVIRSLSG-HFSS 569
            |.|...||..:|.||:|:.|.|:    :.....:|||:.:....:..|:..|.::.::|. |..:
Worm   539 QQLLFHFGRSVQLLLSQSPYRDISIPWSPFYASDWDAADMFPTFLQMFVTKPNLLATISSPHQIT 603

  Fly   570 GEPLEAELSQKMRLLKTQLAGYNLCQDLYLADLDVELH----RSNAFWLEVVRKLWPVYQCMPLD 630
            .:.|..|.:..:.|..::.:.:...:.|:.:|.|:.::    |...|||::.::::..|......
Worm   604 KQSLTEEHANSVALTISRASLWETYRTLFWSDFDLSIYEMEDRKQKFWLDMYKQMYEEYFPFKRA 668

  Fly   631 KKDAHPCSLTDIFA-GDWAAAQFSHLYSRLIAADISSSFAEQRSEENYAVVGRRYKQTFLSCGGS 694
            |.|..|||.|.||| ....:..:..|::.::|.||..:|.|   |:|....|.|.|.|.|:.|..
Worm   669 KNDYQPCSFTPIFALQPHMSMYYRKLWAEMLALDIHETFDE---EDNEVQTGERLKTTILNRGSG 730

  Fly   695 VPTAEVFRRFQGRDPSAEAL 714
            ....|:|:|||||:||..|:
Worm   731 DVAKELFKRFQGRNPSVGAI 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	177/713 (25%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	127/468 (27%)
ZK550.3	NP_503059.2	Peptidase_M3	298..756	CDD:366637	127/468 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156779
Domainoid	1	1.000	158	1.000	Domainoid score	I2512
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I2542
Isobase	1	0.950	-	0	Normalized mean entropy	S1976
OMA	1	1.010	-	-		QHG56544
OrthoDB	1	1.010	-	-		D642479at2759
OrthoFinder	1	1.000	-	-		FOG0001673
OrthoInspector	1	1.000	-	-		oto17618
orthoMCL	1	0.900	-	-		OOG6_100561
Panther	1	1.100	-	-	LDO	PTHR11804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2240
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.790