DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11771 and Y67H2A.7

DIOPT Version :9

Sequence 1:	NP_651314.1	Gene:	CG11771 / 42984	FlyBaseID:	FBgn0039252	Length:	730	Species:	Drosophila melanogaster
Sequence 2:	NP_502558.2	Gene:	Y67H2A.7 / 178290	WormBaseID:	WBGene00013464	Length:	692	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	142/736 - (19%)
Similarity:	269/736 - (36%)	Gaps:	201/736 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SAVENSVKALESDLHSGKQLNAASIFRELDTVTGPLETTWGVAKALYLGNSTLIPTKSYMNIHER 139
            :||:.|..||..:|.:..| |..:..:.:|.::..:..:..:|:.:             ..:|..
Worm    51 AAVKKSTDALIQELLTPSQ-NPRTSIQIVDDISNEICKSADLAECV-------------RQLHSE 101

  Fly   140 ARNARAAK-----FC--------NQTVYKALK--DASSDSGPDEQRMRQKFLL--EGKLNGLTLD 187
            .....||:     ||        |..:|:.||  :.:..|..|:...|...||  :.:.:|:.|.
Worm   102 PEFRNAAEDVSRNFCELVESLNTNTALYQKLKSSEITESSRLDDVDKRTLTLLLDDFEQSGVHLK 166

  Fly   188 KDKQDGLKELLTHLGRERANFKNKVNMAVHSFGQIITDFNLVRDFPPSLLEATARDPGQPMTGPW 252
            .::::...:|.:.:....|.|:...:..| |.|:    |:..:...||.:..       |::...
Worm   167 DNQKEQFVQLSSEIFDAGARFQQNCDRIV-SVGK----FDQAKYGLPSQIYT-------PVSNSL 219

  Fly   253 KITLQPQVVDGFLKHCPERMQRWNVWRASVLKASSQQEKSLENSTHIEKIRGLRKRQANLLGYES 317
            ..:.:..|.:.|.:|                  ...||      ::::.:...|.:.:.|.|:||
Worm   220 DRSKRKMVYNTFYRH------------------DDIQE------SYLQHLISSRHQLSQLTGFES 260

  Fly   318 FADMSMQTKMVGSVDNLKQIFAKLLKFAGPAQSVELEKL-----QGFAQDSG---------CE-- 366
            ||..:.:..::.:.|.::.....:::....|...||..|     |...||:.         .|
Worm   261 FAHRAQRNSLLENYDTVRSFLWGVVEKCRGAFEKELAVLIDVSAQCSQQDNNNGNNEISTIAEHD 325

  Fly   367 -------YKLEAYDVAYWRRKQLAAEHGLQDQKLREFFPLPRVLSGLFALSEKLFGIKIVEQP-- 422
                   |:..|||:|     |::       |:...||....:.:|...|:::|:|::::|:|
Worm   326 LGFLMHLYRESAYDIA-----QVS-------QQSSPFFTFNSIWNGFSTLTQRLYGVRLIEEPLI 378

  Fly   423 NAEVWHPA--VKFYDVFDADSVNSSTPVGGFYVDCYSKEHKFGRNNGWMVG-----IRNSNKSAG 480
            :.|:|:.:  :|...|   |..|:.  :|..|||...:..|       .||     :|.|.:.:.
Worm   379 SGEMWNSSGVMKLQAV---DEQNNE--LGVIYVDVSIRPEK-------AVGDCHYTVRCSKQLSD 431

  Fly   481 LT---PLCALIFNFSEPQSPDAKPPLLGYDDLQMLFKTFGSGLQHLLTQAGYSDLAGLSNIEWDA 542
            .|   |:..|.....:..|...:...:.:...:.:|...|..:..:|.:..|..:|| :....|.
Worm   432 GTWQMPILVLSLGLVDGHSSQWRNSRVSFHSAETMFHELGHAMHSILGRTKYQHVAG-TRCPQDF 495

  Fly   543 SQVSGHVMSNFLDD----PTVIR-------SLSGHFSSGEPLEAELSQKMRLLKTQLAGYNLCQD 596
            |::..::|..|..|    ..:||       .||  ..|...|.|.......:...|.|.|.|
Worm   496 SEIPSNLMEYFFSDLGVMTDIIRRTDRPEEQLS--IESAATLLASRHSFTAIETVQQAAYGL--- 555

  Fly   597 LYLADLDVELH-------------RSNAFWLEVVRKLWPVYQCMPLDKKDAHPCSLTDIFAGDWA 648
                 .|:|:|             .:...:.:::.|..|..|..| |....|....|    ..:.
Worm   556 -----YDLEVHGPIAAPQIASGRMTTTELFHDIMNKTMPHIQRSP-DSAFQHRFHHT----VQYG 610

  Fly   649 AAQFSHLYSRLIAADISSSFAEQRSEENYAVVGRRYKQTFLS---------CGGSVPTAEVFRRF 704
            |..:|:|.:|..|..|                   ::|.||:         |     .|||....
Worm   611 AKYYSYLVARASACLI-------------------WQQRFLNDPFSRKWGDC-----WAEVQSHG 651

  Fly   705 QGRDPSAEALLKSLDIFEPSQ 725
            .|..|:  .||:.:..|.|::
Worm   652 GGHHPA--VLLEKILGFRPTE 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11771	NP_651314.1	PRK10911	49..720	CDD:182832	140/729 (19%)
CG11771	NP_651314.1	Peptidase_M3	264..720	CDD:279740	103/523 (20%)
Y67H2A.7	NP_502558.2	M3A_MIP	33..677	CDD:341052	142/736 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0339
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D642479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820