DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-2 and TUT7

DIOPT Version :9

Sequence 1:	NP_001262941.1	Gene:	Trf4-2 / 42983	FlyBaseID:	FBgn0039251	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_011517313.1	Gene:	TUT7 / 79670	HGNCID:	25817	Length:	1551	Species:	Homo sapiens

Alignment Length:	318	Identity:	74/318 - (23%)
Similarity:	118/318 - (37%)	Gaps:	85/318 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LCLLHQEIEQFYNYIRSTPTEFCLRAGAVRRIEDVVLSIWPSASVDLFGSFRTGLNLPDSDIDLV 89
            |.:|.|...|.|.....|..|...|....:.:|..:...:|...:.||||.:.|.....||:|:.
Human   998 LNILDQVCIQCYKDFSPTIIEDQAREHIRQNLESFIRQDFPGTKLSLFGSSKNGFGFKQSDLDVC 1062

  Fly    90 VYYKFWNP-------RLLHELQNEL-VSQGVTDPDTVTVLDKASVPVVKFTDLISRIRFDVT-FN 145
            :.......       |.:.||...| ...|:.:   :..:..|.||:|||..|.|.:..|:: :|
Human  1063 MTINGLETAEGLDCVRTIEELARVLRKHSGLRN---ILPITTAKVPIVKFFHLRSGLEVDISLYN 1124

  Fly   146 SVA-------SGVQAADLIKDFIRHFPELPKLVMVLKQFLSLHGFNEVYNSGGVSSYALTLMVIS 203
            ::|       |...|.|         |.:..|...:|.|..:....:. :.|.:||||.||||:.
Human  1125 TLALHNTRLLSAYSAID---------PRVKYLCYTMKVFTKMCDIGDA-SRGSLSSYAYTLMVLY 1179

  Fly   204 FLQQH----------------------------------------ARSNRRLSEHSKLALLLIQF 228
            ||||.                                        :...:......:|.|.|::|
Human  1180 FLQQRNPPVIPVLQEIYKGEKKPEIFVDGWNIYFFDQIDELPTYWSECGKNTESVGQLWLGLLRF 1244

  Fly   229 LDYYGRKFDFFKYGISVLGQGGCVEKARLRS--TLGENNWQS-VLCIEDPVTPTNDIG 283
               |..:|||.::.||:          |.:|  |..:..|.| .:.||||....:::|
Human  1245 ---YTEEFDFKEHVISI----------RRKSLLTTFKKQWTSKYIVIEDPFDLNHNLG 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-2	NP_001262941.1	NT_PAP_TUTase	52..161	CDD:143392	29/124 (23%)
Trf4-2	NP_001262941.1	PAP_assoc	221..280	CDD:281779	19/61 (31%)
TUT7	XP_011517313.1	NT_PAP_TUTase	315..427	CDD:143392
		PAP_assoc	550..599	CDD:281779
		NT_PAP_TUTase	1021..1138	CDD:143392	28/119 (24%)
		PAP_assoc	1233..1286	CDD:281779	19/65 (29%)
		TUTF7_u4	1371..1450	CDD:293237
		ZnF_C2HC	1452..1468	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810