DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trf4-2 and Tut1

DIOPT Version :9

Sequence 1:NP_001262941.1 Gene:Trf4-2 / 42983 FlyBaseID:FBgn0039251 Length:407 Species:Drosophila melanogaster
Sequence 2:NP_932110.1 Gene:Tut1 / 70044 MGIID:1917294 Length:869 Species:Mus musculus


Alignment Length:291 Identity:59/291 - (20%)
Similarity:103/291 - (35%) Gaps:105/291 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 VTVLDKASVPVVKFTDLISRIRFDVTFNSVASGVQAADLIKDFIRHFPELP----KLVMVLKQFL 178
            |..:..|..|||||....|.:..||:.::     :.|.....|:....|:.    .||..|:.:.
Mouse   361 VQTVPSARRPVVKFCHRPSGLHGDVSLSN-----RLALYNSRFLNLCSEMDGRVRPLVYTLRCWA 420

  Fly   179 SLHGFNEVYNSGG---VSSYALTLMVISFLQQH--------ARSNRRLSEHSK------------ 220
            ..:|.     |||   :::|||||:||.|||..        |:..:|..|..:            
Mouse   421 QHNGL-----SGGGPLLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRAGEGEQVEVDGWDCSFPK 480

  Fly   221 -------------LALLLIQFLDYYGRKFDFFKYGISVLGQGGCVEKAR------LRSTLGENNW 266
                         |:.||.||...           :|.|...|.:...|      :...|..:.|
Mouse   481 DASRLEPSTNVEPLSSLLAQFFSC-----------VSCLDLSGSLLSLREGRPLMVAEGLPSDLW 534

  Fly   267 QSV----LCIEDPVTPTNDIG-----------------------------RSS----YGVLGVMQ 294
            :.:    :.::||...::::.                             |||    :|:|.::|
Mouse   535 EGLRLGPMNLQDPFDLSHNVAANVTGRVAKRLQSCCGAAASYCRSLQYQQRSSRGRDWGLLPLLQ 599

  Fly   295 GFGAAFVKLSKLVDSDSSKIVGPILANIVEV 325
            ....:.:..:||:...|:.....|:| :|:|
Mouse   600 PSSPSSLLSAKLIPLPSAPFPQVIMA-LVDV 629

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Trf4-2NP_001262941.1 NT_PAP_TUTase 52..161 CDD:143392 11/42 (26%)
PAP_assoc 221..280 CDD:281779 13/68 (19%)
Tut1NP_932110.1 ZnF_U1 14..47 CDD:197732
RRM_TUT1 54..127 CDD:240725
RRM <56..>140 CDD:223796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..144
NT_PAP_TUTase 179..403 CDD:143392 12/46 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..247
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..335
KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250|UniProtKB:Q9H6E5 601..869 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 775..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 803..822
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5260
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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