DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-2 and TUT1

DIOPT Version :9

Sequence 1:	NP_001262941.1	Gene:	Trf4-2 / 42983	FlyBaseID:	FBgn0039251	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_073741.3	Gene:	TUT1 / 64852	HGNCID:	26184	Length:	874	Species:	Homo sapiens

Alignment Length:	313	Identity:	70/313 - (22%)
Similarity:	106/313 - (33%)	Gaps:	121/313 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 VTVLDKASVPVVKFTDLISRIRFDVT-----------FNSVASGVQAADLIKDFIRHFPELPKLV 171
            |..:..|..|||||....|.:..||:           |.|:.|.:..            .:..||
Human   358 VQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALHNSRFLSLCSELDG------------RVRPLV 410

  Fly   172 MVLKQFLSLHGFNEVYNSGG-VSSYALTLMVISFLQ--------------QHA------------ 209
            ..|:.:....|.:   .||. :|:|||||:||.|||              |.|
Human   411 YTLRCWAQGRGLS---GSGPLLSNYALTLLVIYFLQTRDPPVLPTVSQLTQKAGEGEQVEVDGWD 472

  Fly   210 ----RSNRRLSEH---SKLALLLIQFL------DYYGRKFDFFKYGISVLGQGGCVEKARLRSTL 261
                |...||...   ..|:.||.||.      |..|.... .:.|.::...||          |
Human   473 CSFPRDASRLEPSINVEPLSSLLAQFFSCVSCWDLRGSLLS-LREGQALPVAGG----------L 526

  Fly   262 GENNWQSV----LCIEDPVTPTNDIGRSSYGVLGVMQGFGAAFVKLSKLVDSDSSKIVGPILANI 322
            ..|.|:.:    |.::||...::::               ||.|         :|::.|    .:
Human   527 PSNLWEGLRLGPLNLQDPFDLSHNV---------------AANV---------TSRVAG----RL 563

  Fly   323 VEVPQSIINYRAWVHYNFQHLLTPE---LPCADSLVQPSPTGSTSPSASASAS 372
            ....::..||...:.|..:.....:   ||    |:|||     |||:..||:
Human   564 QNCCRAAANYCRSLQYQRRSSRGRDWGLLP----LLQPS-----SPSSLLSAT 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-2	NP_001262941.1	NT_PAP_TUTase	52..161	CDD:143392	13/53 (25%)
Trf4-2	NP_001262941.1	PAP_assoc	221..280	CDD:281779	16/68 (24%)
TUT1	NP_073741.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..334
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000269\|PubMed:28589955	598..874		6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..662
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	705..761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910