DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trf4-2 and TUT4

DIOPT Version :9

Sequence 1:	NP_001262941.1	Gene:	Trf4-2 / 42983	FlyBaseID:	FBgn0039251	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_005270733.1	Gene:	TUT4 / 23318	HGNCID:	28981	Length:	1652	Species:	Homo sapiens

Alignment Length:	301	Identity:	73/301 - (24%)
Similarity:	117/301 - (38%)	Gaps:	71/301 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ASVDLFGSFRTGLNLPDSDIDLVVYYKFWNPRLLHELQNELVSQGVTD---------PDTVTVL- 121
            |.:.||||.:.|....|||:|:.:..:.      ||...:|..:.:.:         |....:|
Human   991 ARLCLFGSSKNGFGFRDSDLDICMTLEG------HENAEKLNCKEIIENLAKILKRHPGLRNILP 1049

  Fly   122 -DKASVPVVKFTDLISRIRFDVT-FNSVASGVQAADLIKDFIRHFPELPKLVMVLKQFLSLHGFN 184
             ..|.||:|||....|.:..|:: :|::|.  ....::..:....|.:..|...:|.|.......
Human  1050 ITTAKVPIVKFEHRRSGLEGDISLYNTLAQ--HNTRMLATYAAIDPRVQYLGYTMKVFAKRCDIG 1112

  Fly   185 EVYNSGGVSSYALTLMVISFLQQH---------------------------------ARSNRRLS 216
            :. :.|.:||||..|||:.||||.                                 ....:||.
Human  1113 DA-SRGSLSSYAYILMVLYFLQQRKPPVIPVLQEIFDGKQIPQRMVDGWNAFFFDKTEELKKRLP 1176

  Fly   217 EHSK----LALLLIQFLDYYGRKFDFFKYGISVLGQGGCVEKARLRSTLGENNWQS-VLCIEDPV 276
            ...|    |..|.:..|.:|..:|||.:|.||       :.:.:|.:|. |..|.| .:.||||.
Human  1177 SLGKNTESLGELWLGLLRFYTEEFDFKEYVIS-------IRQKKLLTTF-EKQWTSKCIAIEDPF 1233

  Fly   277 TPTNDIGRSSYGVLGVMQGF-GAAFVKLSKLVDSDSSKIVG 316
            ...:::|.   ||...|..| ..||:...||..:....::|
Human  1234 DLNHNLGA---GVSRKMTNFIMKAFINGRKLFGTPFYPLIG 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trf4-2	NP_001262941.1	NT_PAP_TUTase	52..161	CDD:143392	25/105 (24%)
Trf4-2	NP_001262941.1	PAP_assoc	221..280	CDD:281779	19/59 (32%)
TUT4	XP_005270733.1	NT_PAP_TUTase	375..487	CDD:143392
		PAP_assoc	628..677	CDD:281779
		NT_PAP_TUTase	971..1089	CDD:143392	25/105 (24%)
		PAP_assoc	1184..1237	CDD:281779	19/60 (32%)
		PTZ00368	<1280..1375	CDD:173561
		CytochromB561_N	1375..>1516	CDD:286826
		DUF1421	<1383..1650	CDD:284607
		FAM75	1423..>1484	CDD:291323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810