DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and Anks1b

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_030101220.1	Gene:	Anks1b / 77531	MGIID:	1924781	Length:	1339	Species:	Mus musculus

Alignment Length:	1339	Identity:	329/1339 - (24%)
Similarity:	467/1339 - (34%)	Gaps:	573/1339 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHG---------PLS---SFRRSPSINCQDMNGYTSL 53
            |||||.||||:|.|::..|:|||  |.::.|         |||   |..|.|::||.|.:|||:|
Mouse     1 MGKDQELLEAARTGNVALVEKLL--SGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTAL 63

  Fly    54 HHACLNGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIEN 118
            |||.||||.:||..||.:.|..:|.|.:|..|:.||||.|..:|||:|:.|.|:.:..|.|..||
Mouse    64 HHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNEN 128

  Fly   119 ETPLHSGAQHGHNAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKR 183
            ||.||..||:||:.|||:||....||.|||:..:|.|||||.:|||:||:.::..:|:
Mouse   129 ETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPN------- 186

  Fly   184 LEDDNEELLGCMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKS 248
                   |:.|...|    ||.||||:|||||.||:.||.||:||:..|..|||||||||.||..
Mouse   187 -------LMSCNTRK----HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD 240

  Fly   249 VVVTLLKAGIYVHATDGNGRTALDILSDYPPHVTYDIVGAINEFTQAA-------REHQKPLVVE 306
            ||..||:.||..:..|..|||.||||.::|...:..|...:.::.:.|       .||.:....:
Mouse   241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYLEGAGRSAAVLEEHAQEDTAQ 305

  Fly   307 NGTQSLPKRLYEKNSQRQKVPPRQR--------KKQDHQANGLSHSLSSLDIFAKPPENYLQMKP 363
            ....|.|....:|...........:        :::|:....|.|::|         ::||
Mouse   306 ETHLSSPAESPQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTIS---------DHYL---- 357

  Fly   364 IIHQKSCDNMS-----DFRTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRSYEYI----- 418
                   ||:|     :...|||..:.:...:...|  .....:.:..|...|:..:|.:
Mouse   358 -------DNLSKISEEELGKNGSQSVRTSSTINLSP--GEVEDEEEDPNSCGPTGLWEALTPCNG 413

  Fly   419 --NL------------LRNGSHSDDNSAS----TSSNSAVRQQAVATYVEMK---LPTPPVPKPR 462
              ||            .||.....:.|||    .|.|.....:.|.|.|..|   |.....|.||
Mouse   414 CRNLGFPMLAQESYPKKRNFPMEMEPSASLDTFPSENENFLCELVDTAVTKKPCSLEIARAPSPR 478

  Fly   463 TRINGEYNDYANVVPIEEGSCVAAVDNNNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTIFNFM 527
            |       |.|:.|.|   :......:.|:|.|           ||||..||:...|.:.|...:
Mouse   479 T-------DNASEVAI---TAPGTSHHRNSSTG-----------PTPDCSPPSPDTALKNIVKVI 522

  Fly   528 QPATLRKNSLL----------------------------EPAESPRTTNSVSSDQVE----EYVA 560
            :|...::.|::                            .||.|| .|:||.:.:|:    |:..
Mouse   523 RPQPKQRTSIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPAASP-PTSSVETTEVKNEGAEHAD 586

  Fly   561 DI---------------PFAGLFKGSTLNLSS------------DVVDGIGAVPGDREFLQSPSM 598
            |:               .||||..||:....|            ...||    |.:.....||..
Mouse   587 DLSQQEDDEPPKEYDAGQFAGLLHGSSPACESPENPFHLYGKRNTCEDG----PDEASLANSPLP 647

  Fly   599 VRSAHVQN-------------------HRRSLSKQRYSALGEDFSAS------------------ 626
            .:...::|                   |:|:...:.::.:|...|.|
Mouse   648 FKQTPIENNPEPSVKKVKPKVVSRTIFHKRNHQLENHTIVGTRMSRSGSRNGDQWGVNPGGFVER 712

  Fly   627 ---------------------------------------RV------------------------ 628
                                                   ||
Mouse   713 ACTLGRIRSLPKALIDMHLSKNVSKSDSDLIAYPSKDKARVNWSKSSTAERSSKDNSERTPSFTS 777

  Fly   629 -WAEIDTIFEN----IGNE--------------------------------------------VS 644
             |.|||.|..:    |.:|                                            |.
Mouse   778 EWEEIDKIMNSIDVGINSELEGMNAQCSELYFMADWVAWESQRELALHLGPSWEDVHWGPRCPVQ 842

  Fly   645 TVEQEVEEF------------------------VED----------------------------- 656
            ||.|.:|..                        :||
Mouse   843 TVGQWLESIGLPQYENHLMANGFDSVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMRP 907

  Fly   657 -------PSSL----------------------------------------------------SL 662
                   |:|:                                                    ||
Mouse   908 IGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWELELINVLKISLIGHRKRILASL 972

  Fly   663 ED---------SRQSLHIRDPAE---------------------------LLLG----------- 680
            .|         ..:|:.:|:|:.                           ::.|
Mouse   973 GDRLHDDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYF 1037

  Fly   681 --------------------------------------------------RKPSAASSN-----W 690
                                                              |.|:.|:::     |
Mouse  1038 DDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEPSITLRPPNEATASTPVQYW 1102

  Fly   691 CHSPYTFIYGEIRYSLFYLGSTVIRKLQGTLSTRKSIQKLKIDENLKSAASVSDFSLLENCTTST 755
            .|.|...|:....|..|||||.:|::|:||.||:.:..|::                 .||..||
Mouse  1103 QHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMR-----------------ANCQKST 1150

  Fly   756 KYLKAANHQTRLNVDIAVSCVGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFAYITKE--QD 818
            :.:|...     .:.::||..||||||...|..|..|:|.||:|..||.|||..||||||:  .:
Mouse  1151 EQMKKVP-----TIILSVSYKGVKFIDAANKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 1210

  Fly   819 LHYCHVFMVDSLELAKEIIMTLGQAFEVAYQLAL-SRQG 856
            .||||||....:.||.|||:|||||||||||||| :|:|
Mouse  1211 HHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKG 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	34/74 (46%)
		ANK repeat	7..46	CDD:293786	20/50 (40%)
		ANK	43..171	CDD:238125	67/127 (53%)
		ANK repeat	48..79	CDD:293786	17/30 (57%)
		Ank_2	53..148	CDD:289560	48/94 (51%)
		ANK repeat	81..115	CDD:293786	14/33 (42%)
		ANK	112..254	CDD:238125	70/141 (50%)
		ANK repeat	117..148	CDD:293786	18/30 (60%)
		Ank_2	122..230	CDD:289560	50/107 (47%)
		ANK repeat	204..232	CDD:293786	18/27 (67%)
		Ank_5	221..273	CDD:290568	29/51 (57%)
		ANK repeat	234..264	CDD:293786	17/29 (59%)
		PTB_Anks	688..857	CDD:269972	75/177 (42%)
Anks1b	XP_030101220.1	PHA02874	7..385	CDD:165205	154/417 (37%)
		ANK repeat	7..56	CDD:293786	20/50 (40%)
		ANK repeat	58..89	CDD:293786	17/30 (57%)
		Ank_2	63..158	CDD:372319	48/94 (51%)
		ANK repeat	91..125	CDD:293786	14/33 (42%)
		ANK repeat	127..158	CDD:293786	18/30 (60%)
		ANK repeat	160..191	CDD:293786	13/44 (30%)
		Ank_2	165..256	CDD:372319	51/108 (47%)
		ANK repeat	193..223	CDD:293786	20/33 (61%)
		ANK repeat	226..256	CDD:293786	17/29 (59%)
		Retinal	<480..>629	CDD:373855	34/163 (21%)
		SAM_AIDA1AB-like_repeat1	840..906	CDD:188898	7/65 (11%)
		SAM_AIDA1AB-like_repeat2	911..975	CDD:188899	4/63 (6%)
		PTB_Anks	1100..1249	CDD:269972	74/170 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm8806
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920