DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and CASKIN1

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_065815.1	Gene:	CASKIN1 / 57524	HGNCID:	20879	Length:	1431	Species:	Homo sapiens

Alignment Length:	756	Identity:	205/756 - (27%)
Similarity:	318/756 - (42%)	Gaps:	171/756 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65
            |||:|.|::|.:|.|:.|..:||:........|....:..::|.||.:|:::||||.|||::.::
Human     1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELI 65

  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130
            .|||...|.:|:.|.:|..||..|||.|.::.:|::|   ..|:..|..:.|...|||..|||||
Human    66 SLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL---KAGSAVNIPSDEGHIPLHLAAQHGH 127

  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLL--RVYPDLILPYKRLEDDNEELLG 193
            ..|..:||.:.::|.:.:||.:|.||||.:|||:.|||.||  .:...|:.|   ...|..:..|
Human   128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEP---RPGDATDPNG 189

  Fly   194 CMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGI 258
            ..|         ||||::|||..::..||.||:|:|..|.:|:||||||||||..||..||.:||
Human   190 TSP---------LHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGI 245

  Fly   259 YVHATDGNGRTALDILSDYPPHVTYDIVGAINEFT--QAAREHQKPLVVENGTQSLPKRLYEKNS 321
            ..|..:...:|||||               :::||  ||:||              .|:|..:.|
Human   246 NAHVRNTYSQTALDI---------------VHQFTTSQASRE--------------IKQLLREAS 281

  Fly   322 QRQKVPPRQRKKQDHQANGLSHSLSSLDIFAKPPENYLQMKPIIHQKSCDNMSDFRTNGSNLLTS 386
            ...:|    |..:|:..|   :.|:||::.|......|:..|....|.|  :.|.||....:  .
Human   282 AALQV----RATKDYCNN---YDLTSLNVKAGDIITVLEQHPDGRWKGC--IHDNRTGNDRV--G 335

  Fly   387 YKP------VYK--------QPMLPSFRMDSDISNGSVPSRSYEYINLLRNGSHSDDNSASTSSN 437
            |.|      :.|        :|.||..      |:.|.||...|.|.:||......|.|.|.|..
Human   336 YFPSSLGEAIVKRAGSRAGTEPSLPQG------SSSSGPSAPPEEIWVLRKPFAGGDRSGSISGM 394

  Fly   438 SAVRQQAVATYVEMKLPTPPVPKPRTRINGEYNDYANVVPIEEG-SCVAAVDNNNNSNGNGTKLR 501
            :..|.                       :|.:..:|.    .|| ..:|.|.:..:.:.:|.
Human   395 AGGRG-----------------------SGGHALHAG----SEGVKLLATVLSQKSVSESGP--- 429

  Fly   502 LVRHSPTPDYPP----------PTVTEAERTIFNFMQPATLRKNSLLEPAESPRTTNSVS----S 552
                ..:|..||          |.|..|.: ::....|      ..||||...:::.:||    :
Human   430 ----GDSPAKPPEGSAGVARSQPPVAHAGQ-VYGEQPP------KKLEPASEGKSSEAVSQWLTA 483

  Fly   553 DQVEEYVADIPFAGLFKGSTLNLSSDVVDGIGAV-PGDRE-------FLQSPSMVRSAHVQNHRR 609
            .|::.|..:...||....:...::.:.:..||.. ||.|:       .|..|..:......|...
Human   484 FQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPEHKPANLAV 548

  Fly   610 SLS----KQRYSALGE------DFSASRVWAEIDTI-FENIGNEVSTV----------EQEVEEF 653
            .||    .|.|..|.:      ||.....|.::..| ...:|::...:          :.|..::
Human   549 WLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQKAEYAKY 613

  Fly   654 VEDPSSLSLEDSRQSLHIRDPAELLLGRKPSAASSNWCHSP 694
            ...|.......|.:.:.|..|..    .:|:.|.   |.||
Human   614 EGGPLRRKAPQSLEVMAIESPPP----PEPTPAD---CQSP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	20/62 (32%)
		ANK repeat	7..46	CDD:293786	9/38 (24%)
		ANK	43..171	CDD:238125	54/127 (43%)
		ANK repeat	48..79	CDD:293786	13/30 (43%)
		Ank_2	53..148	CDD:289560	37/94 (39%)
		ANK repeat	81..115	CDD:293786	11/33 (33%)
		ANK	112..254	CDD:238125	61/143 (43%)
		ANK repeat	117..148	CDD:293786	13/30 (43%)
		Ank_2	122..230	CDD:289560	43/109 (39%)
		ANK repeat	204..232	CDD:293786	13/27 (48%)
		Ank_5	221..273	CDD:290568	28/51 (55%)
		ANK repeat	234..264	CDD:293786	18/29 (62%)
		PTB_Anks	688..857	CDD:269972	3/7 (43%)
CASKIN1	NP_065815.1	Ank_4	7..69	CDD:290365	20/61 (33%)
		ANK repeat	7..46	CDD:293786	9/38 (24%)
		ANK	43..168	CDD:238125	54/127 (43%)
		ANK repeat	48..79	CDD:293786	13/30 (43%)
		ANK 1	48..77		12/28 (43%)
		Ank_2	53..145	CDD:289560	37/94 (39%)
		ANK repeat	81..112	CDD:293786	11/33 (33%)
		ANK 2	81..110		10/31 (32%)
		ANK	109..241	CDD:238125	61/143 (43%)
		ANK repeat	114..145	CDD:293786	13/30 (43%)
		ANK 3	114..143		13/28 (46%)
		Ank_2	119..218	CDD:289560	44/110 (40%)
		ANK repeat	147..186	CDD:293786	17/41 (41%)
		ANK 4	147..176		14/28 (50%)
		ANK repeat	188..218	CDD:293786	15/38 (39%)
		ANK 5	188..217		14/37 (38%)
		Ank_5	208..261	CDD:290568	30/67 (45%)
		ANK 6	220..249		17/28 (61%)
		ANK repeat	221..251	CDD:293786	18/29 (62%)
		ANK repeat	253..287	CDD:293786	15/66 (23%)
		SH3_Caskin1	284..345	CDD:212995	17/71 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..373		7/30 (23%)
		Caskin1-CID	373..421	CDD:293208	15/74 (20%)
		CASK-binding. /evidence=ECO:0000250	375..469		25/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..406		5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	421..447		4/32 (13%)
		SAM	470..532	CDD:197735	11/61 (18%)
		SAM_caskin1,2_repeat1	471..536	CDD:188896	12/64 (19%)
		SAM_caskin1,2_repeat2	537..607	CDD:188897	11/69 (16%)
		SAM	549..604	CDD:197735	10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	630..977		7/25 (28%)
		Ten_N	<651..>809	CDD:284015
		Caskin-Pro-rich	876..947	CDD:293512
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1072..1377
		Caskin-tail	1370..1431	CDD:293238
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1390..1416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710