DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11168 and caskin2

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_009304988.1	Gene:	caskin2 / 564253	ZFINID:	ZDB-GENE-041001-137	Length:	1308	Species:	Danio rerio

Alignment Length:	811	Identity:	205/811 - (25%)
Similarity:	335/811 - (41%)	Gaps:	221/811 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65
            |||:|.||.|.:.||:....|||.........|....:..::|.||.:|:::||||.|.|.::::
Zfish     1 MGKEQDLLLAVKNGDLPLAHKLLAKIKTNRNKLLGSTKRLNVNYQDQDGFSALHHAALTGTTDLL 65

  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130
            .|||...|.:|:.|..|..||..|||.|..|.|.:||.   .||:.|..:.:.:.|||..||:||
Zfish    66 SLLLEAQATVDIKDSNGMRPLHYAAWQGKADSVLLLLR---AGASVNGASHDGQIPLHLAAQYGH 127

  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCM 195
            ..|..:||.:.::|...|...:|.||||.:||||:|.|.||.....:.|    ||.:..:
Zfish   128 YDVSEMLLQHQSNPCTVNKVKKTPLDLACEFGRLKVTQLLLNSNMVVAL----LEGNGRD----- 183

  Fly   196 PIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYV 260
                   :|.||||:|||||.::..||.||:|:|..|.:|:|||||||.||..||..||.|||.|
Zfish   184 -------NTPLHLAARNGHKDIIRLLLKAGIDINRTTKSGTALHEAALYGKTEVVKLLLDAGIDV 241

  Fly   261 HATDGNGRTALDILSDYPPHVTYDIVGAINEFT--QAAREHQKPLVVENGTQSLPKRLYEKNSQR 323
            :..:...:|||||               :|:||  .|::|.::.|...:|...:
Zfish   242 NIRNTYNQTALDI---------------VNQFTTSHASKEIKQLLRDASGALQV----------- 280

  Fly   324 QKVPPRQRKKQDHQANGLSHSLSSLDIFAKPPENYLQM------KPIIH--QKSCDNMSDF---- 376
                   |..:|:..   .|..::|:|.|......|:.      |..||  |:..|.:..|
Zfish   281 -------RALKDYWN---LHDPTALNIRAGDVITVLEQHMDGRWKGHIHDSQRGTDRVGFFPPSI 335

  Fly   377 -----RTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRSYEYINLLRNGSHSDDNSASTSS 436
                 |.:|..|       .:|..||..|  ..|.:.::||.:..:.      ||:||:....||
Zfish   336 VEVISRRSGGGL-------SRQASLPVQR--HHILSRALPSHNSHHT------SHTDDSYTLYSS 385

  Fly   437 -------NSAVRQQAVATYVEMKLPTPP--VPKP------RTRIN-GEYN--------------- 470
                   ::::.|.:.|      ||..|  :.||      ||.:| |:.|
Zfish   386 THPTVTHHNSLDQHSGA------LPDSPSALCKPEDIWVLRTSLNAGDRNSIGSAGSMGSSRSAG 444

  Fly   471 -------DYANVVPIEEGSCVAAVDNNNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTIFNFMQ 528
                   ::.|..|.:..|   ||.:|:....:..:|......||....|.:.....|...:..:
Zfish   445 SGQSTEGNFPNNGPYQSPS---AVQDNSKMPPSAGELLEQNQDPTKHMDPHSGALGRRIPLSSSR 506

  Fly   529 PA---TLRKNSLLEPAESPRTTNSVS--------------SDQVEEYVADIPFAGLFKGSTLNLS 576
            |.   .:.:..||:...:.:..|:|.              ..|:|:|.::...||....:...::
Zfish   507 PGEQHVIHQQLLLDGRHTSKQINAVKRALRDAEAIYQWLCEFQLEQYTSNFLTAGYDVPTISRMT 571

  Fly   577 SDVVDGIGAV-PGDR-------------EFLQS--PS----MVRSAHVQNHRRSLSKQRYSALG- 620
            .:.:..||.. ||.|             |:|..  ||    .:.:..:..:::.|::..|.::.
Zfish   572 PEDLTAIGVTKPGHRKKISMEIGNLNIPEWLPDYIPSDIGKWLSAIGLPQYQKKLAENGYDSISI 636

  Fly   621 -EDFSASRVWAEIDTI-FENIGNE---------VSTVEQ-------------------------- 648
             :|.:    |.::..| ...:|::         :|.|::
Zfish   637 VQDIT----WEDLQEIGITKLGHQKKLMLAVKRLSDVQKARKTQAEGQALLQHRKAPPALELVAI 697

  Fly   649 EVEEFVEDPSS------LSLEDSRQSLHIRD 673
            |..:..:.|||      |:.:||..|:.:::
Zfish   698 EHHDTSDCPSSPLSPKMLTFQDSELSMELQN 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	20/62 (32%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK	43..171	CDD:238125	53/127 (42%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..148	CDD:289560	37/94 (39%)
		ANK repeat	81..115	CDD:293786	14/33 (42%)
		ANK	112..254	CDD:238125	58/141 (41%)
		ANK repeat	117..148	CDD:293786	11/30 (37%)
		Ank_2	122..230	CDD:289560	42/107 (39%)
		ANK repeat	204..232	CDD:293786	16/27 (59%)
		Ank_5	221..273	CDD:290568	28/51 (55%)
		ANK repeat	234..264	CDD:293786	18/29 (62%)
		PTB_Anks	688..857	CDD:269972
caskin2	XP_009304988.1	Ank_4	7..69	CDD:290365	20/61 (33%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK	43..168	CDD:238125	53/127 (42%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..145	CDD:289560	37/94 (39%)
		ANK repeat	81..112	CDD:293786	14/33 (42%)
		ANK	114..235	CDD:238125	57/136 (42%)
		ANK repeat	114..145	CDD:293786	11/30 (37%)
		Ank_2	152..245	CDD:289560	50/108 (46%)
		ANK repeat	158..213	CDD:293786	27/70 (39%)
		ANK repeat	215..245	CDD:293786	18/29 (62%)
		ANK repeat	247..281	CDD:293786	12/66 (18%)
		SH3_Caskin2	278..339	CDD:212996	13/81 (16%)
		Caskin1-CID	414..>451	CDD:293208	5/36 (14%)
		SAM_caskin1,2_repeat1	536..600	CDD:188896	10/63 (16%)
		SAM	537..589	CDD:197735	10/51 (20%)
		SAM_caskin1,2_repeat2	601..671	CDD:188897	11/73 (15%)
		SAM	607..668	CDD:197735	8/64 (13%)
		Caskin-Pro-rich	904..991	CDD:293512
		Caskin-tail	1248..1308	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.710