DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and CG4393

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001287483.1	Gene:	CG4393 / 42764	FlyBaseID:	FBgn0039075	Length:	1325	Species:	Drosophila melanogaster

Alignment Length:	1351	Identity:	412/1351 - (30%)
Similarity:	546/1351 - (40%)	Gaps:	531/1351 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65
            |||||..|||:|.|:|..::|:|...:||.|||:|.||...:|.||..||::|||||||||.:||
  Fly     1 MGKDQEFLEAARNGNISHIEKVLTQKAKRAGPLASLRRGTGVNVQDSGGYSALHHACLNGHEDIV 65

  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130
            ||||:|.|..::||.|||:||.||||||..:||::||.|....|:.|.||||.|||||..|||||
  Fly    66 RLLLAHEASPNLPDSRGSSPLHLAAWAGETEIVRLLLTHPYRPASANLQTIEQETPLHCAAQHGH 130

  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLI--LPYKRLEDDNEELLG 193
            ...:|:||.:.|||.:||:..:|.||||||:||||.||.|:|.:|:||  |..:.||........
  Fly   131 TGALALLLHHDADPNMRNSRGETPLDLAAQYGRLQAVQMLIRAHPELIAHLGTEALERGTPSPSS 195

  Fly   194 -CMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAG 257
             ..|.:.||.|||||||||||||.|||.||:|||.||:||.:|:||||||||||::||.||||||
  Fly   196 PASPSRAIFPHTCLHLASRNGHKSVVEVLLSAGVSVNLLTPSGTALHEAALCGKENVVRTLLKAG 260

  Fly   258 IYVHATDGNGRTALDILSDYPPHVTYDIVGAINEFTQAA----------REH------------- 299
            |.::|||..||||||||.::|||||..||..||.|....          |:|
  Fly   261 INLNATDNEGRTALDILREFPPHVTKHIVAVINNFRNQMDTDEGDEVIYRQHSGPPNSGRGQNKH 325

  Fly   300 ----QKPLV----------VENGTQSLPKRLYEK--------------NSQRQKVPPRQRKKQD- 335
                |.||.          :.|.:.|:.:..|.|              .|....:.|..|..||
  Fly   326 HSQQQPPLSNHYHFNSNNHLLNHSHSMQQSGYSKQRLSAGNGGPYNGGKSLDSALQPEDRFYQDL 390

  Fly   336 ------HQANGL--------SHSLSS----------------------LDIFA------KPPENY 358
                  |..|.:        |.||||                      :..||      |||...
  Fly   391 NAHSPLHSQNEMGGGYSVSPSSSLSSFEPASVSPRSRCSTGGLGQPMHMSTFAPAGPPKKPPRRN 455

  Fly   359 LQMKPI---------IHQKSCDNMSDFRTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRS 414
            |.:.|.         ....|..:.|....:|.|      .|.:||...|  ..|..|:|||...|
  Fly   456 LSVSPTHAGPGQQFSYSSPSSQSQSQSHGHGQN------QVRRQPASES--PYSHQSHGSVGGMS 512

  Fly   415 YEYINLLRNGSHSDDNSAS---------------TSSNSAVRQQAVATYVEMKLPTP-------- 456
            ::... ||....:|...||               :|||..:.:|..::.:..:...|
  Fly   513 FDETQ-LRERQRNDRLYASARQSTRSAIAGGMSLSSSNDMLDRQCSSSELNSETSVPNSSGDSPA 576

  Fly   457 ------PVPKPR---TRINGEYNDYANVVPIEEGSCVAAVDNNNNSNG-------NG------TK 499
                  |:|.||   |:::.|....|....::..:....:..|.||:|       ||      .|
  Fly   577 TNSMKRPIPAPRSSTTKLSKELLKSAESATLKSYNPNRKLKRNRNSSGANGAAKSNGGDENCEAK 641

  Fly   500 LRL------VRHSPTPDYPPPTVTEAERTIFNFMQPAT---LRKNSLLE---------------- 539
            .::      .:..||||:|||:.::|||||...::|.:   .|:::||:
  Fly   642 QQIPSSPTHYKQPPTPDHPPPSSSQAERTIHERIRPLSQEYKRRSALLQLQAAQQLMIETGSSPS 706

  Fly   540 -----------------------PAESPRTTNSV----------SSDQVEEYVADIPFAGLFKGS 571
                                   ||.|..:.:|.          |:|.|||:|:|:|||||.||:
  Fly   707 KLLPTLSTPGYDYDDTVTVVPRCPAPSSGSLSSSISCSDHSLSHSTDYVEEFVSDVPFAGLLKGA 771

  Fly   572 ----------------------TL----------------------------------NLSSDVV 580
                                  ||                                  |.|||||
  Fly   772 SQQLKEQPEVKLKIQEESKPQQTLPRVRPPIPTKPAIPEKKFAKPPTTPTNQSLEANGNSSSDVV 836

  Fly   581 DGIGAVPGDREFLQSPSMV-RSAHVQNHRRSLSKQRYSA---------LGEDFSASRVWAEIDTI 635
                 :...|...:|||.. ..:.|::..:|.:|...|.         |...|:|.....:|..|
  Fly   837 -----IKPPRSPSKSPSKTSNKSPVKSPGKSPAKSPGSGHSAARNSINLLSPFNAEEARKKISEI 896

  Fly   636 FENIG------------------------NE---------------------------------- 642
            .||.|                        ||
  Fly   897 IENFGSGILNTSITPTHDIELDFEDMEVPNERRELATRLRAAGLLHLERILFENGYDNYKFVNNV 961

  Fly   643 -----------------------------------------------VSTVEQ--------EVEE 652
                                                           |:|::|        |..|
  Fly   962 FEEPDIPLLHIPERDAPKLLRFVQSLPPAEFQPQVPVKTQQENKQMGVATLQQWLNTIALPEYLE 1026

  Fly   653 FV--------------------------------------------------------------- 654
            |.
  Fly  1027 FFNKHLYNTIESVCGVWDVELQTVLEINKLGHRRRILQSLAYIRQMRDSDSKSQKTPLGENNETN 1091

  Fly   655 -----------EDPSSL---------SLEDSRQS----------------LHIRDPAELLLGRKP 683
                       |.|..|         |:...|:|                |.||.|:|||||...
  Fly  1092 QLTTNGNGTAREAPPRLPANPVHHRNSITGYRKSRPAPPPPAPPARKTAALQIRAPSELLLGLPA 1156

  Fly   684 SAASSNWCHSPYTFIYGEIRYSLFYLGSTVIRKLQGTLSTRKSIQKLK--IDENLKSAASVSDFS 746
            :..::.|.||..|.:...|.|.:.||||||:::|:||.||:|||||||  .|..:||.:.:|
  Fly  1157 NLRTTEWRHSAQTLLNEHINYEVQYLGSTVVKELRGTESTKKSIQKLKTSADGEVKSGSPLS--- 1218

  Fly   747 LLENCTTSTKYLKAANHQTRLNVDIAVSCVGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFA 811
                                    :|:...||:|.|.:.|..||.|:|:||||.||||||||:||
  Fly  1219 ------------------------LAICHRGVEFKDVNSKRTICEHEIQNINCACQDSEDLRHFA 1259

  Fly   812 YITKEQDLHYCHVFMVDSLELAKEIIMTLGQAFEVAYQLALSRQGTSLNEE 862
            ||||||||||||||:|:|.:||.|||:|||||||||||||| |.|.:...|
  Fly  1260 YITKEQDLHYCHVFLVESTDLASEIILTLGQAFEVAYQLAL-RDGITTTPE 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	34/62 (55%)
		ANK repeat	7..46	CDD:293786	17/38 (45%)
		ANK	43..171	CDD:238125	77/127 (61%)
		ANK repeat	48..79	CDD:293786	19/30 (63%)
		Ank_2	53..148	CDD:289560	57/94 (61%)
		ANK repeat	81..115	CDD:293786	18/33 (55%)
		ANK	112..254	CDD:238125	86/144 (60%)
		ANK repeat	117..148	CDD:293786	17/30 (57%)
		Ank_2	122..230	CDD:289560	61/110 (55%)
		ANK repeat	204..232	CDD:293786	22/27 (81%)
		Ank_5	221..273	CDD:290568	37/51 (73%)
		ANK repeat	234..264	CDD:293786	21/29 (72%)
		PTB_Anks	688..857	CDD:269972	88/170 (52%)
CG4393	NP_001287483.1	Ank_2	<10..79	CDD:289560	36/68 (53%)
		ANK	43..171	CDD:238125	77/127 (61%)
		ANK repeat	49..79	CDD:293786	19/29 (66%)
		Ank_2	53..148	CDD:289560	57/94 (61%)
		ANK repeat	81..115	CDD:293786	18/33 (55%)
		ANK	112..257	CDD:238125	86/144 (60%)
		ANK repeat	117..148	CDD:293786	17/30 (57%)
		Ank_2	122..233	CDD:289560	61/110 (55%)
		ANK repeat	181..233	CDD:293786	28/51 (55%)
		Ank_5	224..276	CDD:290568	37/51 (73%)
		ANK repeat	237..267	CDD:293786	21/29 (72%)
		SAM_AIDA1AB-like_repeat2	1005..1069	CDD:188899	6/63 (10%)
		SAM	1009..1075	CDD:197735	6/65 (9%)
		PTB_Anks	1161..1305	CDD:269972	89/171 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462398
Domainoid	1	1.000	57	1.000	Domainoid score	I7237
eggNOG	1	0.900	-	-		E2759_KOG0507
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I2451
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm6490
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.900