DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and Anks1b

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_017450317.2	Gene:	Anks1b / 314721	RGDID:	1565556	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	1293	Identity:	331/1293 - (25%)
Similarity:	465/1293 - (35%)	Gaps:	514/1293 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHG---------PLS---SFRRSPSINCQDMNGYTSL 53
            |||||.||||:|.|::..|:|||  |.::.|         |||   |..|.|::||.|.:|||:|
  Rat     1 MGKDQELLEAARTGNVALVEKLL--SGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGYTAL 63

  Fly    54 HHACLNGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIEN 118
            |||.||||.:||..||...|..:|.|.:|..|:.||||.|..:|||:|:.|.|:.:..|.|..||
  Rat    64 HHAALNGHKDIVLKLLQFEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSRVNEQNNEN 128

  Fly   119 ETPLHSGAQHGHNAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKR 183
            ||.||..||:||:.|||:||....||.|||:..:|.|||||.:|||:||:.::..:|:
  Rat   129 ETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMIISAHPN------- 186

  Fly   184 LEDDNEELLGCMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKS 248
                   |:.|...|    ||.||||:|||||.||:.||.||:||:..|..|||||||||.||..
  Rat   187 -------LMSCNTRK----HTPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHEAALFGKVD 240

  Fly   249 VVVTLLKAGIYVHATDGNGRTALDILSDYPPHVTYDIVGAINEFTQAA-------REHQKPLVVE 306
            ||..||:.||..:..|..|||.||||.::|...:..|...:.::.:..       .||.:....:
  Rat   241 VVRVLLETGIDANIKDSLGRTVLDILKEHPSQKSLQIATLLQDYLEGVGRSVVLEEEHAQEDTAQ 305

  Fly   307 NGTQSLPKRLYEKNSQRQKVPPRQRKKQDHQANGLSHSLSSLDIFAKPPENYLQMKPIIHQKSCD 371
            ....|.|.:           .|.|:.|.:.....||..|..:.:..:...::..:...|.....|
  Rat   306 ETRLSSPAQ-----------SPSQKTKSETVTGELSKLLDEIKLCQEKDYSFEDLCHTISDHYLD 359

  Fly   372 NMS-----DFRTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRSYEYIN-----------L 420
            |:|     :...|||..:.:...:...|  .....:.:..|...|:..:|.:.           :
  Rat   360 NLSKISEEELGKNGSQSVRTSSTINLSP--GEVEDEEEDPNSCGPTGLWEALTPCNGCRNLGFPM 422

  Fly   421 LRNGSHSDDN--------SAS----TSSNSAVRQQAVATYVEMK---LPTPPVPKPRTRINGEYN 470
            |...|:....        |||    .|.|.....:.|.|.|..|   |.....|.|||
  Rat   423 LAQESYPKKRNYPMEIVPSASLDTFPSENENFLCELVDTAVTKKPCSLEIARAPSPRT------- 480

  Fly   471 DYANVVPIEEGSCVAAVDNNNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTIFNFMQPATLRKN 535
            |.|:.|.|   :......:.|:|.|           ||||..||:...|.:.|...::|...::.
  Rat   481 DNASEVAI---TAPGTGHHRNSSTG-----------PTPDCSPPSPDTALKNIVKVIRPQPKQRT 531

  Fly   536 SLL----------------------------EPAESPRTTNSVSSDQVE----EYVADI------ 562
            |::                            .|..|| .|:||.:.:::    |:..|:
  Rat   532 SIVSSLDFQRMNHNQEYFEISTSTGCTSFTSSPPVSP-PTSSVETTEIKNEGAEHTDDLSQQEDD 595

  Fly   563 ---------PFAGLFKGST---------------LNLSSDVVDGIGAVPGDREFLQS-------- 595
                     .||||..||:               .|...|..:..........|.|:
  Rat   596 EHPKEYDAGQFAGLLHGSSPACEAPENPFHLYGKRNQGEDGQEEASLANSPLPFKQTPIENNPEP 660

  Fly   596 ------PSMV-------RSAHVQNHR----------------------------------RSLSK 613
                  |.:|       ||..::||.                                  |||.|
  Rat   661 SVKKIKPKVVSRTIFHKRSHQLENHTIVGTRMSRGGSRNGDQWGVNPGGFVERACTLGRIRSLPK 725

  Fly   614 --------QRYSALGEDFSA------SRV-------------------------WAEIDTIFEN- 638
                    :..|....|..|      :||                         |.|||.|..:
  Rat   726 ALIDMHLSKNVSKSDSDLIAYPSKDKARVNWSKSSTAERSSKDNSERTPSFTSEWEEIDKIMNSI 790

  Fly   639 ---IGNE----------VSTVEQEVEEF------------------------VED---------- 656
               |.:|          |.||.|.:|..                        :||
  Rat   791 DVGINSELEGMNGPRCPVQTVGQWLESIGLPQYENHLTANGFDNVQFMGSNVMEDQDLLEIGILN 855

  Fly   657 --------------------------PSS------------------------------------ 659
                                      |:|
  Rat   856 SGHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWELEL 920

  Fly   660 -----LSL----------------EDSRQ----SLHIRDPAE----------------------- 676
                 :||                ||..|    |:.:|:|:.
  Rat   921 INVLKISLIGHRKRILASLGDRLHEDPPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLD 985

  Fly   677 ----LLLG--------------------------------------------------------- 680
                ::.|
  Rat   986 VPHIIMQGDARRRRNENYFDDIPRSKLERQMAQQSSVCEIWTNQNAGFPFSAIHQVHNTGDWGEP 1050

  Fly   681 ----RKPSAASSN-----WCHSPYTFIYGEIRYSLFYLGSTVIRKLQGTLSTRKSIQKLKIDENL 736
                |.|:.|:::     |.|.|...|:....|..|||||.:|::|:||.||:.:..|::
  Rat  1051 SITLRPPNEATASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMR----- 1110

  Fly   737 KSAASVSDFSLLENCTTSTKYLKAANHQTRLNVDIAVSCVGVKFIDHDKKTAICCHDIENINCVC 801
                        .||..||:.:|...     .:.::||..||||||...|..|..|:|.||:|..
  Rat  1111 ------------ANCQKSTEQMKKVP-----TIILSVSYKGVKFIDAANKNIIAEHEIRNISCAA 1158

  Fly   802 QDSEDLRYFAYITKE--QDLHYCHVFMVDSLELAKEIIMTLGQAFEVAYQLAL-SRQG 856
            ||.|||..||||||:  .:.||||||....:.||.|||:|||||||||||||| :|:|
  Rat  1159 QDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKG 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	34/74 (46%)
		ANK repeat	7..46	CDD:293786	20/50 (40%)
		ANK	43..171	CDD:238125	67/127 (53%)
		ANK repeat	48..79	CDD:293786	17/30 (57%)
		Ank_2	53..148	CDD:289560	48/94 (51%)
		ANK repeat	81..115	CDD:293786	14/33 (42%)
		ANK	112..254	CDD:238125	70/141 (50%)
		ANK repeat	117..148	CDD:293786	18/30 (60%)
		Ank_2	122..230	CDD:289560	50/107 (47%)
		ANK repeat	204..232	CDD:293786	18/27 (67%)
		Ank_5	221..273	CDD:290568	29/51 (57%)
		ANK repeat	234..264	CDD:293786	17/29 (59%)
		PTB_Anks	688..857	CDD:269972	75/177 (42%)
Anks1b	XP_017450317.2	PTB_Anks	1067..1216	CDD:269972	74/170 (44%)
		PHA02874	7..386	CDD:165205	153/409 (37%)
		ANK repeat	7..56	CDD:293786	20/50 (40%)
		ANK repeat	58..89	CDD:293786	17/30 (57%)
		Ank_2	63..158	CDD:403870	48/94 (51%)
		ANK repeat	91..125	CDD:293786	14/33 (42%)
		ANK repeat	127..158	CDD:293786	18/30 (60%)
		ANK repeat	160..191	CDD:293786	13/44 (30%)
		Ank_2	165..256	CDD:403870	51/108 (47%)
		ANK repeat	193..223	CDD:293786	20/33 (61%)
		ANK repeat	226..256	CDD:293786	17/29 (59%)
		SAM_AIDA1AB-like_repeat1	807..873	CDD:188898	7/65 (11%)
		SAM_AIDA1AB-like_repeat2	878..942	CDD:188899	4/63 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm9053
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.020