DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and Anks1a

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_038954611.1	Gene:	Anks1a / 309639	RGDID:	1309183	Length:	1204	Species:	Rattus norvegicus

Alignment Length:	1193	Identity:	314/1193 - (26%)
Similarity:	447/1193 - (37%)	Gaps:	447/1193 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKR----------------------------HGPLSSFR 37
            |||:|.||||:|.|.:..|:|||  |.||                            | ||||..
  Rat     1 MGKEQELLEAARTGHLPAVEKLL--SGKRLSSGFGGGGGGGSGSGGGSGGGGLGSSSH-PLSSLL 62

  Fly    38 ---RSPSINCQDMNGYTSLHHACLNGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVK 99
               |.|::||.|..|||.||||.||||.::|.:||.::||.:|.|.:|..||.||||.|...||:
  Rat    63 SMWRGPNVNCVDSTGYTPLHHAALNGHRDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQIVR 127

  Fly   100 MLLMHSP--TGANP-------------------NAQTIENETPLHSGAQHGHNAVVAILLSYGAD 143
            :|:...|  |..|.                   ||:..:|||.||..||:||..||..||....|
  Rat   128 LLIHQGPSHTRVNEQNALEIKELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKALLEELTD 192

  Fly   144 PAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCMPIKHIFTHTCLHL 208
            |.:|||.|:|.|||||.:|||:||:.||..:|:              ||.|...|    ||.|||
  Rat   193 PTMRNNKFETPLDLAALYGRLEVVKLLLSAHPN--------------LLSCSTRK----HTPLHL 239

  Fly   209 ASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYVHATDGNGRTALDI 273
            |:|||||.||:.||.||:|.|..|..|||||||||.||..||..||.|||.|:..|..|.||||.
  Rat   240 AARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGIDVNIKDNRGLTALDT 304

  Fly   274 LSDYPPHVTYDIVGAINEFTQAARE---------HQKPLVVENGTQSL-PKRL------------ 316
            :.|.|...:..|...|.:.....|.         .|.||:  :.|.:: ||.|
  Rat   305 VRDLPSQKSQQIAALIEDHMTGRRSVKDVDKTSTAQLPLL--SCTDAIAPKSLGSVEKAVTEPTL 367

  Fly   317 -----------YE-----------------KNSQRQK--------------VPPRQR-------- 331
                       ||                 ::|.|..              |.||:|
  Rat   368 DSDILAEEEGPYEALYNAVSCHSLDSTASGRSSDRDSVNKEAEATGARAAGVRPRERPPPPAKPP 432

  Fly   332 ---------------------------------------------------------KKQDHQAN 339
                                                                     :.:||:.:
  Rat   433 PDEEEEERVDKKYLPLAASEGLALRPRMQGSAPQEEEEHPYELLLTAETKKLGTTDGRTEDHRQS 497

  Fly   340 GLSHSLSSLD-----------------------------IFAKPPENYLQMKPIIHQKSCDNMS- 374
            |.|.|..|::                             :...|.:|:.:..   .|.:|...|
  Rat   498 GGSRSQDSVEGQDGQVPEQFSGLLHGSSPVCEVGQDPFQLLTVPSQNHPESS---QQDACQEASM 559

  Fly   375 -----DFRTNGSNLLTSYKPVYKQPMLPSFRMDSDISNGSVPSRSYEYINLLRN-------GSHS 427
                 ..::.|:          .||.:......:.:|.|.....|..|::.|.:       |:..
  Rat   560 QLEEPGEQSTGA----------PQPGILDQSKRAGLSAGLTALASRTYLDALTHTVPLHPAGAEE 614

  Fly   428 DDNSASTSSNSAVRQQAVATYVEMKLPTPPVPKPRTR------INGEYNDYANVVPIEE---GSC 483
            :|.|.|.:                    ||..||:..      ::...:|.....|.|:   ||
  Rat   615 EDGSRSRA--------------------PPTSKPKAELKLSRSLSKSDSDLLTCSPTEDTTMGS- 658

  Fly   484 VAAVDNNNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTI------FNFMQPATLRKNSLLEPAE 542
                .:.:.||.:..|.||.:   :|.:.... .|.|:.:      .:|.|             |
  Rat   659 ----RSESLSNCSIGKKRLEK---SPSFASEW-DEIEKIMSSIGEGIDFSQ-------------E 702

  Fly   543 SPRTTNSVSSDQ----------VEEYVADIPFAGL----FKGSTLNLSSDVVD-GIGAVPGDREF 592
            ..:.:.|.:.:|          :::|.:.:...|.    |.||.:....|:.: ||......|:.
  Rat   703 QQKISGSRTLEQSVGEWLESIGLQQYESKLLLNGFDDVRFLGSNVMEDQDLREIGISDPQHRRKL 767

  Fly   593 LQS--------------------PSMVRSAHVQNHRRSLSKQRYSALGEDFSASRVWAEIDTI-- 635
            ||:                    ||.:.|..:|::..|.....||::.   :...:| |::.:
  Rat   768 LQAARSLPKVKALGYDGVSPASVPSWLDSLGLQDYIHSFLSSGYSSID---TVKNLW-ELELVNV 828

  Fly   636 --FENIGNE----VSTVEQEVEEFVEDP----------------SSLSLEDS------------- 665
              ...:|:.    .|..::..||..:.|                |.||..||
  Rat   829 LKVHLLGHRKRIIASLADRPYEEPPQKPPRFSQLRCQDLISQTSSPLSQNDSCTGRSADLLLPSV 893

  Fly   666 ------RQSLH-------------IRDPAELLLG-RKPSAAS-----SNWCHSPYTFIYGEIRYS 705
                  ..|||             ..:|:|..|. |.||.|:     .:|.|.|...|:....|.
  Rat   894 DTSRRRHDSLHDPGTTSRAEHFRVQEEPSESKLTLRPPSLAAPYAPVQSWQHRPEKLIFESCGYE 958

  Fly   706 LFYLGSTVIRKLQGTLSTRKSIQKLKIDENLKSAASVSDFSLLENCTTSTKYLKAANHQTRL-NV 769
            ..||||.:|:.|:||.||:.:..|::                           |:..|..:: .:
  Rat   959 ANYLGSMLIKDLRGTESTQDACAKMR---------------------------KSTEHMKKIPTI 996

  Fly   770 DIAVSCVGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFAYITKEQDL--HYCHVFMVDSLEL 832
            .::::..||||:|...|..|..|:|.||:|..||.|||..||||||:...  ||||||....:.|
  Rat   997 ILSITYKGVKFMDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNL 1061

  Fly   833 AKEIIMTLGQAFEVAYQLALSRQ 855
            ..|||:||||||||||||||..|
  Rat  1062 TYEIILTLGQAFEVAYQLALQAQ 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	35/93 (38%)
		ANK repeat	7..46	CDD:293786	22/69 (32%)
		ANK	43..171	CDD:238125	67/148 (45%)
		ANK repeat	48..79	CDD:293786	17/30 (57%)
		Ank_2	53..148	CDD:289560	46/115 (40%)
		ANK repeat	81..115	CDD:293786	16/54 (30%)
		ANK	112..254	CDD:238125	72/141 (51%)
		ANK repeat	117..148	CDD:293786	15/30 (50%)
		Ank_2	122..230	CDD:289560	52/107 (49%)
		ANK repeat	204..232	CDD:293786	18/27 (67%)
		Ank_5	221..273	CDD:290568	31/51 (61%)
		ANK repeat	234..264	CDD:293786	19/29 (66%)
		PTB_Anks	688..857	CDD:269972	66/171 (39%)
Anks1a	XP_038954611.1	ANK repeat	7..74	CDD:293786	22/69 (32%)
		PHA03095	67..>302	CDD:222980	117/252 (46%)
		ANK repeat	77..107	CDD:293786	17/29 (59%)
		ANK repeat	109..164	CDD:293786	16/54 (30%)
		ANK repeat	166..197	CDD:293786	15/30 (50%)
		ANK repeat	199..230	CDD:293786	17/44 (39%)
		Ank_2	204..295	CDD:403870	56/108 (52%)
		ANK repeat	232..262	CDD:293786	20/33 (61%)
		ANK repeat	265..295	CDD:293786	19/29 (66%)
		SAM_AIDA1AB-like_repeat1	712..778	CDD:188898	12/65 (18%)
		SAM_AIDA1AB-like_repeat2	783..847	CDD:188899	11/67 (16%)
		PTB_Anks	941..1086	CDD:269972	66/171 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349592
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm9053
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.810