DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11168 and Caskin2

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	NP_001100535.1	Gene:	Caskin2 / 303678	RGDID:	1309738	Length:	1200	Species:	Rattus norvegicus

Alignment Length:	697	Identity:	194/697 - (27%)
Similarity:	302/697 - (43%)	Gaps:	144/697 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65
            ||::|.|:.|.:.||:..|.||:.........|....:..:||.||.:|:::||||.|.|...::
  Rat     1 MGREQDLILAVKNGDVTCVQKLVAKVKAAKTKLLGSTKRLNINYQDADGFSALHHAALGGSLELI 65

  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130
            .|||...|.:|:.|..|..||..|||.|..:.||:||..|   |..||.:::.:.|||..||:||
  Rat    66 ALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVKLLLRAS---AAVNAASLDGQIPLHLAAQYGH 127

  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCM 195
            ..|..:||.:.::|.:.|...:|.||||.:||||:|.|.||..:..:.|    ||.:.::
  Rat   128 YEVSEMLLQHQSNPCLVNKLKKTPLDLACEFGRLKVAQLLLNSHLCVAL----LEGEAKD----- 183

  Fly   196 PIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYV 260
            |....:| |.||||::|||::|:..||.||:::|..|..|:|||||||.||..||..||:.|:.|
  Rat   184 PCDPNYT-TPLHLAAKNGHREVIRQLLKAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDV 247

  Fly   261 HATDGNGRTALDILSDYPPHVTYDIVGAINEFT--QAAREHQKPLVVENGTQSLPKRLYEKNSQR 323
            :..:...:|||||               :|:||  ||:||              .|:|..:.|..
  Rat   248 NIRNTYNQTALDI---------------VNQFTTSQASRE--------------IKQLLREASGI 283

  Fly   324 QKVPPRQRKKQDHQANGLSHSLSSLDIFAKPPENYLQMKP------IIH--QKSCDNMSDFRTNG 380
            .||    |..:|...   .|..::|:|.|......|:..|      .||  |:..|.:..|....
  Rat   284 LKV----RALKDFWN---LHDPTALNIRAGDVITVLEQHPDGRWKGHIHESQRGTDRVGYFPPGI 341

  Fly   381 SNLLTSYK--PVYKQP-----MLPSFRMDSDISNGSV--PSRSYEYINLLRNGSHSDDNSASTSS 436
            ..:::...  ||.:.|     :.|||   |.||..|.  |..|..|..|.|.|...|  |.:...
  Rat   342 VEVVSKRVGIPVTRLPSAPTLLRPSF---SRISQPSADDPLPSLTYGQLPRVGLSPD--SPAGDR 401

  Fly   437 NSAVRQQAVATYVEMKLPTPPVPKPRTRINGEYNDYANVVPIEEGSCVAAVDNNNNSNGNGTKLR 501
            ||...:.:|.:.             |:..:|:                    ::..:||:.|.|.
  Rat   402 NSVGSEGSVGSI-------------RSAGSGQ--------------------SSEGTNGHSTGLL 433

  Fly   502 LVRHSPTPD-----------YPPPTVTEAERTIFNFMQ----PATLRKNSLLEPAESPRTTNSVS 551
            :....|.|.           .|.|....:.|.:.::..    ...:|...|||..::....|.:|
  Rat   434 IENAQPLPSANEDQVLPGLHAPSPADNLSHRPLASYRSGEIFTQDVRPEQLLEGKDAQAIHNWLS 498

  Fly   552 SDQVEEYVADIPFAGLFKGSTLNLSSDVVDGIGAV-PGDREFLQS-----------PSMVR---- 600
            ..|:|.|.|....||....:...::.:.:..||.. ||.|:.:.|           |:.:.
  Rat   499 EFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLPNYIPVDLL 563

  Fly   601 ----SAHVQNHRRSLSKQRYSALGEDFSASRVWAEIDTIFEN-IGNE 642
                :..:..:.:.|....|.::|  ..|...|.|:..|..| :|::
  Rat   564 EWLCALGLPQYHKQLVSSGYDSMG--LVADLTWEELQEIGVNKLGHQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	20/62 (32%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK	43..171	CDD:238125	54/127 (43%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..148	CDD:289560	38/94 (40%)
		ANK repeat	81..115	CDD:293786	15/33 (45%)
		ANK	112..254	CDD:238125	59/141 (42%)
		ANK repeat	117..148	CDD:293786	11/30 (37%)
		Ank_2	122..230	CDD:289560	42/107 (39%)
		ANK repeat	204..232	CDD:293786	14/27 (52%)
		Ank_5	221..273	CDD:290568	25/51 (49%)
		ANK repeat	234..264	CDD:293786	16/29 (55%)
		PTB_Anks	688..857	CDD:269972
Caskin2	NP_001100535.1	ANK	7..135	CDD:238125	48/130 (37%)
		Ank_4	7..61	CDD:290365	18/53 (34%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..145	CDD:289560	38/94 (40%)
		ANK	76..209	CDD:238125	56/145 (39%)
		ANK repeat	85..112	CDD:293786	14/29 (48%)
		ANK repeat	114..145	CDD:293786	11/30 (37%)
		Ank_2	152..251	CDD:289560	48/108 (44%)
		ANK repeat	158..219	CDD:293786	27/70 (39%)
		ANK	183..>258	CDD:238125	34/80 (43%)
		ANK repeat	221..251	CDD:293786	16/29 (55%)
		SH3_Caskin2	284..345	CDD:212996	15/67 (22%)
		SAM_caskin1,2_repeat1	487..552	CDD:188896	14/64 (22%)
		SAM	493..548	CDD:197735	14/54 (26%)
		SAM_caskin1,2_repeat2	553..623	CDD:188897	10/58 (17%)
		SAM	561..620	CDD:197735	9/50 (18%)
		Caskin-Pro-rich	797..881	CDD:293512
		Draxin	899..>1067	CDD:292187
		Caskin-tail	1143..1200	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710