DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and ANKS1A

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_011512733.1	Gene:	ANKS1A / 23294	HGNCID:	20961	Length:	1166	Species:	Homo sapiens

Alignment Length:	1170	Identity:	324/1170 - (27%)
Similarity:	449/1170 - (38%)	Gaps:	394/1170 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKR-------------------------------HGPLS 34
            |||:|.||||:|.|.:..|:|||  |.||                               | |||
Human     1 MGKEQELLEAARTGHLPAVEKLL--SGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSH-PLS 62

  Fly    35 SFR---RSPSINCQDMNGYTSLHHACLNGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQD 96
            |..   |.|::||.|..|||.||||.||||.::|.:||.::||.:|.|.:|..||.||||.|...
Human    63 SLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLAAWKGDAQ 127

  Fly    97 IVKMLLMHSP--TGANP-------------------NAQTIENETPLHSGAQHGHNAVVAILLSY 140
            ||::|:...|  |..|.                   ||:..:|||.||..||:||..||.:||..
Human   128 IVRLLIHQGPSHTRVNEQNALEIKELKKYGPFDPYINAKNNDNETALHCAAQYGHTEVVKVLLEE 192

  Fly   141 GADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCMPIKHIFTHTC 205
            ..||.:|||.|:|.|||||.:|||:||:.||..:|:              ||.|...|    ||.
Human   193 LTDPTMRNNKFETPLDLAALYGRLEVVKMLLNAHPN--------------LLSCNTKK----HTP 239

  Fly   206 LHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYVHATDGNGRTA 270
            ||||:|||||.||:.||.||:|.|..|..|||||||||.||..||..||.||..|:..|.:|.||
Human   240 LHLAARNGHKAVVQVLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTA 304

  Fly   271 LDILSDYPPHVTYDIVGAINEFTQAARE---------HQKPLV-------------VENGTQSLP 313
            ||.:.:.|...:..|...|.:.....|.         .|.||:             ||.....|
Human   305 LDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQGDVEKAVTEL- 368

  Fly   314 KRLYEKNSQRQKVPPRQR-------KKQDHQANGLSHSLSSLDIF-------------------- 351
              :.:.::..::..|.:.       ...|..|:|.|....|.:..
Human   369 --IIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVKPAGVRPRERPPPP 431

  Fly   352 AKPP------------------ENYLQMKPII--------------------------------- 365
            ||||                  ...|.|:|.|
Human   432 AKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYELLLTAETKKVVLVDGKTKD 496

  Fly   366 HQKSCDNMSDFRTNG---------SNLLTSYKPVYKQPMLPSFRM---------DSDISNGSVPS 412
            |::|..:.|.....|         |.||....||.:....| |::         |.....|:...
Human   497 HRRSSSSRSQDSAEGQDGQVPEQFSGLLHGSSPVCEVGQDP-FQLLCTAGQSHPDGSPQQGACHK 560

  Fly   413 RSYEYINLLRNGSHSDDNSASTSSNSAVRQQAVATYVEMKLPT---------------------- 455
            .|   :.|...|.|    :...|..||:.|.....|: ..|||
Human   561 AS---MQLEETGVH----APGASQPSALDQSKRVGYL-TGLPTTNSRSHPETLTHTASPHPGGAE 617

  Fly   456 -----------PPVPKPRTR------INGEYNDYANVVPIEEGSCVAAVDNNNNSNGN---GTKL 500
                       ||..||:..      ::...:|.....|.|:    |.:.:.:.|..|   |.|
Human   618 EGDRSGARSRAPPTSKPKAELKLSRSLSKSDSDLLTCSPTED----ATMGSRSESLSNCSIGKK- 677

  Fly   501 RLVRHSPTPDYPPPTVTEAERTI------FNFMQPATLRKNSLLEPAESPRTTNSVSSDQVEEYV 559
               |...:|.:.... .|.|:.:      .:|.|..  :|.|.|...|. .....:.|..:::|.
Human   678 ---RLEKSPSFASEW-DEIEKIMSSIGEGIDFSQER--QKISGLRTLEQ-SVGEWLESIGLQQYE 735

  Fly   560 ADIPFAGL----FKGSTLNLSSDVVD-GIGAVPGDREFLQS--------------------PSMV 599
            :.:...|.    |.||.:....|:.| ||......|:.||:                    ||.:
Human   736 SKLLLNGFDDVHFLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWL 800

  Fly   600 RSAHVQNHRRSLSKQRYSALGEDFSASRVWAEIDTI----FENIGNE----VSTVEQEVEEFVED 656
            .|..:|::..|.....||::.   :...:| |::.:    .:.:|:.    .|..::..||..:.
Human   801 DSLGLQDYVHSFLSSGYSSID---TVKNLW-ELELVNVLKVQLLGHRKRIIASLADRPYEEPPQK 861

  Fly   657 P----------------SSLSLEDS-------------------RQSLHIRDP------------ 674
            |                |.||..||                   ..|||  ||
Human   862 PPRFSQLRCQDLLSQTSSPLSQNDSCTGRSADLLLPPGDTGRRRHDSLH--DPAAPSRAERFRIQ 924

  Fly   675 -----AELLLGRKPSAAS-----SNWCHSPYTFIYGEIRYSLFYLGSTVIRKLQGTLSTRKSIQK 729
                 |:|.| |.||.|:     .:|.|.|...|:....|...||||.:|:.|:||.||:.:..|
Human   925 EEHREAKLTL-RPPSLAAPYAPVQSWQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAK 988

  Fly   730 LKIDENLKSAASVSDFSLLENCTTSTKYLKAANHQTRL-NVDIAVSCVGVKFID-HDKKTAICCH 792
            ::                           |:..|..:: .:.::::..|||||| .:|:..|..|
Human   989 MR---------------------------KSTEHMKKIPTIILSITYKGVKFIDASNKQNVIAEH 1026

  Fly   793 DIENINCVCQDSEDLRYFAYITKEQDL--HYCHVFMVDSLELAKEIIMTLGQAFEVAYQLALSRQ 855
            :|.||:|..||.|||..||||||:...  ||||||....:.|..|||:||||||||||||||..|
Human  1027 EIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEIILTLGQAFEVAYQLALQAQ 1091

Fly 856 855
Human 1092 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	35/96 (36%)
		ANK repeat	7..46	CDD:293786	22/72 (31%)
		ANK	43..171	CDD:238125	67/148 (45%)
		ANK repeat	48..79	CDD:293786	17/30 (57%)
		Ank_2	53..148	CDD:289560	46/115 (40%)
		ANK repeat	81..115	CDD:293786	16/54 (30%)
		ANK	112..254	CDD:238125	72/141 (51%)
		ANK repeat	117..148	CDD:293786	15/30 (50%)
		Ank_2	122..230	CDD:289560	52/107 (49%)
		ANK repeat	204..232	CDD:293786	18/27 (67%)
		Ank_5	221..273	CDD:290568	30/51 (59%)
		ANK repeat	234..264	CDD:293786	18/29 (62%)
		PTB_Anks	688..857	CDD:269972	67/172 (39%)
ANKS1A	XP_011512733.1	ANK repeat	7..77	CDD:293786	22/72 (31%)
		ANK	74..223	CDD:238125	67/148 (45%)
		ANK repeat	80..110	CDD:293786	17/29 (59%)
		Ank_2	84..200	CDD:289560	46/115 (40%)
		ANK repeat	112..167	CDD:293786	16/54 (30%)
		ANK	164..288	CDD:238125	72/141 (51%)
		ANK repeat	169..200	CDD:293786	15/30 (50%)
		ANK repeat	202..233	CDD:293786	17/44 (39%)
		Ank_2	207..298	CDD:289560	55/108 (51%)
		ANK repeat	235..265	CDD:293786	20/33 (61%)
		ANK repeat	268..298	CDD:293786	18/29 (62%)
		SAM_AIDA1AB-like_repeat1	718..784	CDD:188898	14/66 (21%)
		SAM	721..780	CDD:197735	13/58 (22%)
		SAM	788..850	CDD:197735	10/65 (15%)
		SAM_AIDA1AB-like_repeat2	789..853	CDD:188899	11/67 (16%)
		PTB_Anks	947..1093	CDD:269972	67/172 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm8577
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.810