Protein Alignment CG11168 and C11E4.6

DIOPT Version :10

• Sequence 1: NP_651311.2
• Gene: CG11168 / 42981
• FlyBaseID: FBgn0039249
• Length: 863
• Species: Drosophila melanogaster
• Sequence 2: NP_509620.2
• Gene: C11E4.6 / 181179
• WormBaseID: WBGene00007520
• Length: 1170
• Species: Caenorhabditis elegans
• Alignment Length: 1195
• Identity: 254/1195 - (21%)
• Similarity: 404/1195 - (33%)
• Gaps: 398/1195 - (33%)

  Fly     7 LLEASRAGDIKTVDKLLEHSSKRHGPLSS-----FRRSPSINCQD----MNGYTSLHHACLNGHS 62
            :::|.:.|:...|...|  |||:...:.|     ..||.|....|    .:.:|.||||.|...:
 Worm    13 VIDACKKGEYDKVALFL--SSKKGKKIRSGLKFFTTRSDSHWLADYKDEKSDFTLLHHAVLENQN 75

  Fly    63 NIVRLLLSHNALLDV-PDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANP----NAQTIENETPL 122
            .|.:||:.:..||.: ...:...|:.||||.|:.:||||||:.  |...|    ||..|.|||||
 Worm    76 QISKLLMDYEPLLLLCKSTKNILPIHLAAWNGNLEIVKMLLLQ--TMEKPADILNAVNIFNETPL 138

  Fly   123 HSGAQHGHNAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLIL--PYKRLE 185
            |...|..|..||..|:...|||.|||.:.:..:|:|::.|..:.::.|.:.:|...:  .|:.|.
 Worm   139 HLAVQRCHLEVVFYLIKKNADPFIRNENKENVIDVASRIGSAEAIRMLCQKWPKFPVQSAYESLR 203

  Fly   186 DDNEELLGCMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVV 250
            ....::....|..:.|     |||::..|.:.::.|...|..:|..|..|:|||.|:.||:...|
 Worm   204 VGTPDIKRPFPAIYPF-----HLAAKYNHVECMQALREHGFSINYTTEDGTALHVASACGQAEAV 263

  Fly   251 VTLLKAGIYVHATDGNGRTALDILSDYPPHVTYDIV------------------------GAINE 291
            ..||:.|:.....:.:|:|.|.::.|...:...:|.                        |...|
 Worm   264 RFLLEIGVNTDIKNQHGQTVLQMIIDLQENRRNEIAHFVKNPEGWKECRTIIEGMDRRDSGRETE 328

  Fly   292 FTQAAREHQ---KPLVVENGTQSLPKRLYEKNS--QRQKVPPRQRK-KQDHQANGL--------- 341
            .:|:..|.:   :||..:...|..|.:....:|  |...:..|.|. ..|.....|
 Worm   329 GSQSDNEREAIWQPLPSQASVQVYPDQRRNNHSIYQPPSISARLRDLSPDDSTEALNSVRSEGPY 393

  Fly   342 -SHSL------SSLDIFAKPPE--NYLQMKPIIHQK--SCDNMSD-FRTNGSNLLTSYKPVYKQ- 393
             :||:      |.||   :.|.  .:....|..|.|  ||...|| ..|...|:.|  :|..||
 Worm   394 TTHSINRTWNSSMLD---RAPRTGRFPLTSPSYHSKHYSCQRSSDTLPTRLKNVRT--RPTEKQI 453

  Fly   394 -PMLP----SFRMDS----------DISN------GSVPSRSYEYINLLRNGSHSDDNSASTSSN 437
             .:||    ::...|          .|||      .:||:.|..::.         .||....|.
 Worm   454 ASVLPGDNCAYNSPSKFNEWQKSQLTISNRPPAPYDNVPNNSAIFVR---------PNSPIARSA 509

  Fly   438 SAVRQQAVATYVEMKLPTPPVP------------------------------------------- 459
            |..||...||..::...:|.:|
 Worm   510 SLRRQSGYATLPKLATYSPRIPDHGRPDLNDAFIQDPDKTMDRSLNRNQFSISRTTCDREESLGL 574

  Fly   460 ------------------------------KPRTRINGEYNDYANVVPIEE------GSCVAAVD 488
                                          :.|.|.||.    |.:...||      ||.:.:..
 Worm   575 TQSPRLDTRASSITSSLTYACSTLDKDKFFRERERDNGR----APLAMPEEITGSVTGSVIYSQG 635

  Fly   489 N-NNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTIF--NFMQPATLRKNSLLEPAESPRTTNSV 550
            | |.:.|||..|             ...||    .||  :.|:|::   ||...| .||.|:.:.
 Worm   636 NANQHLNGNYEK-------------DNNVT----AIFLEDVMRPSS---NSAESP-PSPNTSKAF 679

  Fly   551 SSDQV--EEYVADIPFAGLFKG--STLNLSSDVVDGIGAVPGDREFLQSPSMVRSAHVQNHRRSL 611
            ..|.:  :..:.|......|.|  |:.|||....:....|..:..|.:....||... ||...:|
 Worm   680 IFDALCGKSRLVDSTNVDFFSGFSSSSNLSHRSTESTSKVQMNSSFTEPEEPVRIRR-QNGTTNL 743

  Fly   612 ---------------SKQRYSALGEDFSASRVWAEIDTIFENIGNE-------VSTVEQEVEEFV 654
                           |.|:.....|:.|    |..::::|::.|..       |...|..|..::
 Worm   744 MLNSLSPTDNLSSPSSDQKSDTTSEEPS----WDRVESVFDSFGAAPCRESVFVREYEPRVAVYL 804

  Fly   655 EDPSSLSLEDSRQSLHIRDPAELLLGRKPSAASSNWCHSPYTF---------------------- 697
            .|..|.:|..:......||...||:.::|... ..|..|....
 Worm   805 RDRGSKALSVTLVEDEFRDHKSLLVKKQPKTI-IEWLESDVMLAPVAADSVGALLQTHGYDRMDQ 868

  Fly   698 IYGEIRYSL-------------------------------FY----------------------- 708
            :.|.|..|:                               ||
 Worm   869 LKGIINRSILTEIGVDDVTKFKIMSEIEKLKDDVASAGRFFYVSEWLNFIGLQDYISNFVGAGYK 933

  Fly   709 -----------------LGST----VIRKLQG----------TLSTRKSIQKL--------KIDE 734
                             ||.|    :.|.|..          ..:.|..|:.|        :..:
 Worm   934 HMAKLTEIDWDTARLMQLGVTRPGHIARMLHSFKKAEDEKRKEYNNRLQIKPLMSPPPLPPRSKQ 998

  Fly   735 NLKSAASVSDFSLLENCTTSTKYLKAANH------------------QTRL-----------NVD 770
            |..:.....||..::|.......:..|:|                  .||:           .|.
 Worm   999 NNCAECPQGDFDKIKNKLLQGNVVYRAHHLGVLEIGETECSDEAHAAMTRIKESIIDWETIPRVT 1063

  Fly   771 IAVSCVGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFAYITKE-QDLHYCHVFMVDSLELAK 834
            :.::|.|:...|...||.:..:.:..|..||||.:||.:|.::.:: ::..:||.|.|.:..:|.
 Worm  1064 LDLTCNGITIFDETFKTLLDGYGVYTIRVVCQDRKDLNFFCFVARDTENRFFCHTFCVLTSGIAA 1128

  Fly   835 EIIMTLGQAFEVAYQL--ALSRQGT 857
            |||.|:|..||:..::  :|..:||
 Worm  1129 EIITTIGMMFELRSRMDKSLPIEGT 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_651311.2	ANK repeat	117..148	CDD:293786	15/30 (50%)
		ANK repeat	204..232	CDD:293786	7/27 (26%)
		ANK repeat	234..264	CDD:293786	11/29 (38%)
		PTB_Anks	688..857	CDD:269972	50/315 (16%)
		Ank_4	6..69	CDD:372654	20/70 (29%)
		ANK repeat	7..46	CDD:293786	11/43 (26%)
		ANKYR	<42..271	CDD:440430	76/239 (32%)
		ANK repeat	48..79	CDD:293786	11/31 (35%)
		ANK repeat	81..115	CDD:293786	16/37 (43%)
C11E4.6	NP_509620.2	ANKYR	53..299	CDD:440430	78/252 (31%)
		ANK repeat	61..93	CDD:293786	11/31 (35%)
		ANK repeat	95..131	CDD:293786	16/37 (43%)
		ANK repeat	135..164	CDD:293786	14/28 (50%)
		ANK repeat	166..245	CDD:293786	16/83 (19%)
		ANK repeat	247..277	CDD:293786	11/29 (38%)
		SAM	833..901	CDD:197735	6/68 (9%)
		SAM_1	904..965	CDD:425739	7/60 (12%)
		PH-like	1007..1151	CDD:473070	34/143 (24%)