DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and Caskin1

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_006245957.1	Gene:	Caskin1 / 140722	RGDID:	620191	Length:	1437	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	204/780 - (26%)
Similarity:	321/780 - (41%)	Gaps:	180/780 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNG-------YTSLHHACL 58
            |||:|.|::|.:|.|:.|..:||:........|....:..::|.||.:|       :::||||.|
  Rat     1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGPVLHLPSFSALHHAAL 65

  Fly    59 NGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLH 123
            ||::.::.|||...|.:|:.|.:|..||..|||.|.::.:|::|   ..|:..|..:.|...|||
  Rat    66 NGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL---KAGSAVNVPSDEGHIPLH 127

  Fly   124 SGAQHGHNAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLL--RVYPDLILPYKRLED 186
            ..|||||..|..:||.:.::|.:.:||.:|.||||.:|||:.|||.||  .:...|:.|   ...
  Rat   128 LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEP---RPG 189

  Fly   187 DNEELLGCMPIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVV 251
            |..:..|..|         ||||::|||..::..||.||:|:|..|.:|:||||||||||..||.
  Rat   190 DTTDPNGTSP---------LHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVR 245

  Fly   252 TLLKAGIYVHATDGNGRTALDILSDYPPHVTYDIVGAINEFT--QAAREHQKPLVVENGTQSLPK 314
            .||.:||.....:...:|||||               :::||  ||::|              .|
  Rat   246 LLLDSGINAQVRNTYSQTALDI---------------VHQFTTSQASKE--------------IK 281

  Fly   315 RLYEKNSQRQKVPPRQRKKQDHQANGLSHSLSSLDIFAKPPENYLQMKPIIHQKSCDNMSDFRTN 379
            :|..:.|...:|    |..:|:..|   :.|:||::.|......|:..|....|.|  :.|.||.
  Rat   282 QLLREASAALQV----RATKDYCNN---YDLTSLNVKAGDIITVLEQHPDGRWKGC--IHDNRTG 337

  Fly   380 GSNLLTSYKP------VYK--------QPMLPSFRMDSDISNGSV-PSRSYEYINLLRNGSHSDD 429
            ...:  .|.|      :.|        :|..|.       ..||: ||...|.|.:||......|
  Rat   338 NDRV--GYFPSSLGEAIVKRAGSRTGSEPSPPQ-------GGGSLGPSAPPEEIWVLRKPFAGGD 393

  Fly   430 NSASTSSNSAVRQ-------------QAVATYVEMKLPTPPVPKPRTRINGEYNDYANVVPIEEG 481
            .|.|.|:.:..|.             :.:||.:..|..:...|       |:     :.|...||
  Rat   394 RSGSLSNVAGGRSTGGHALHAGAEGVKLLATVLSQKSVSESSP-------GD-----SPVKPPEG 446

  Fly   482 SCVAAVDNNNNSNGNGTKLRLVRHSPTPDYPPPTVTEAERTIFNFMQPATLRKNSLLEPAESPRT 546
            |..||...                       ||.....:  ::....|..|..:|..|...:...
  Rat   447 SSGAARSQ-----------------------PPAAHAGQ--VYGEQPPKKLESSSASEGKSAEAV 486

  Fly   547 TNSVSSDQVEEYVADIPFAGLFKGSTLNLSSDVVDGIGAV-PGDRE-------FLQSPSMVRSAH 603
            :..:::.|::.|..:...||....:...::.:.:..||.. ||.|:       .|..|..:....
  Rat   487 SQWLATFQLQLYAPNFTSAGYDLPTISRMTPEDLTAIGVTKPGHRKKITAEISGLNIPDCLPEHK 551

  Fly   604 VQNHRRSLS----KQRYSALGE------DFSASRVWAEIDTI-FENIGNEVSTV----------E 647
            ..|....||    .|.|..|.:      ||.....|.::..| ...:|::...:          :
  Rat   552 PANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAELQK 616

  Fly   648 QEVEEFVEDPSSLSLEDSRQSLHIRDPAELLLGRKPSAASSNWCHSP--YTF----IYGEIRYSL 706
            .|..::...|.......|.:.:.|..|       .||..::..|.||  .||    :.||::.:|
  Rat   617 AEYSKYEGGPLRRKAPQSLEMMAIESP-------PPSEPAAAECQSPKMTTFQDSELSGELQAAL 674

Fly 707 706
Rat 675 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	20/69 (29%)
		ANK repeat	7..46	CDD:293786	9/38 (24%)
		ANK	43..171	CDD:238125	54/134 (40%)
		ANK repeat	48..79	CDD:293786	13/37 (35%)
		Ank_2	53..148	CDD:289560	37/94 (39%)
		ANK repeat	81..115	CDD:293786	11/33 (33%)
		ANK	112..254	CDD:238125	61/143 (43%)
		ANK repeat	117..148	CDD:293786	13/30 (43%)
		Ank_2	122..230	CDD:289560	43/109 (39%)
		ANK repeat	204..232	CDD:293786	13/27 (48%)
		Ank_5	221..273	CDD:290568	27/51 (53%)
		ANK repeat	234..264	CDD:293786	17/29 (59%)
		PTB_Anks	688..857	CDD:269972	8/25 (32%)
Caskin1	XP_006245957.1	ANK	43..175	CDD:238125	54/134 (40%)
		ANK repeat	56..86	CDD:293786	12/29 (41%)
		Ank_2	60..152	CDD:289560	37/94 (39%)
		ANK repeat	88..119	CDD:293786	11/33 (33%)
		ANK	116..248	CDD:238125	61/143 (43%)
		ANK repeat	121..152	CDD:293786	13/30 (43%)
		Ank_2	126..225	CDD:289560	44/110 (40%)
		ANK repeat	154..193	CDD:293786	17/41 (41%)
		ANK repeat	195..225	CDD:293786	15/38 (39%)
		Ank_5	215..268	CDD:290568	29/67 (43%)
		ANK repeat	228..258	CDD:293786	17/29 (59%)
		ANK repeat	260..294	CDD:293786	14/66 (21%)
		SH3_Caskin1	291..352	CDD:212995	17/71 (24%)
		Caskin1-CID	380..428	CDD:293208	11/47 (23%)
		SAM	479..541	CDD:197735	10/61 (16%)
		SAM_caskin1,2_repeat1	480..545	CDD:188896	10/64 (16%)
		SAM_caskin1,2_repeat2	547..616	CDD:188897	11/68 (16%)
		SAM	558..613	CDD:197735	10/54 (19%)
		Caskin-Pro-rich	884..955	CDD:293512
		Caskin-tail	1375..1437	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0507
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.710