DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11168 and si:dkeyp-9d4.3

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_009304428.1	Gene:	si:dkeyp-9d4.3 / 100148061	ZFINID:	ZDB-GENE-110914-175	Length:	1558	Species:	Danio rerio

Alignment Length:	772	Identity:	203/772 - (26%)
Similarity:	331/772 - (42%)	Gaps:	176/772 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKRHGPLSSFRRSPSINCQDMNGYTSLHHACLNGHSNIV 65
            |||:|.||:|.:..|:.||.:||:...:....|....:..::|.||.:|.::||||.|||:..::
Zfish     1 MGKEQELLQAVKTEDLVTVQRLLQRPKQGKAKLLGAAKKVNVNFQDTDGLSALHHAALNGNVELI 65

  Fly    66 RLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHSPTGANPNAQTIENETPLHSGAQHGH 130
            .|||...:::|:.|.:|..||..|||.|..:.:||||   ..|::.|:|:.|.:.|||..:||||
Zfish    66 SLLLESQSVVDIKDQKGMRPLHYAAWQGKCEPMKMLL---KAGSSVNSQSDEGQIPLHLSSQHGH 127

  Fly   131 NAVVAILLSYGADPAIRNNSFQTALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCM 195
            .....:||.:.::|.:|:::.:|.||||.:|||:.|||.||.......:...:..|.|    |..
Zfish   128 YEGSEMLLQHQSNPCLRDHAGKTPLDLACEFGRVTVVQLLLNSNMCAAMLEPKPSDPN----GIS 188

  Fly   196 PIKHIFTHTCLHLASRNGHKKVVETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYV 260
            |         ||||::|||.::::.|:.||:|:|..|.:|:||||||||||...|..||.:||..
Zfish   189 P---------LHLAAKNGHIEIIKLLIQAGIDINRQTKSGTALHEAALCGKTEAVRLLLDSGISA 244

  Fly   261 HATDGNGRTALDILSDYPPHVTYDIVGAINEF--TQAAREHQKPL-------------------- 303
            ...:...:|||||               :|:|  |||::|.::.|
Zfish   245 GVRNTYCQTALDI---------------VNQFTTTQASKEIKQMLRDASAAMQVRALKDYCNNYD 294

  Fly   304 -------------VVENGTQSLPKR-LYEKNSQRQKV---------------PPRQRKKQDH--- 336
                         |:|..:....|. :::..:...:|               |..|:..:.|
Zfish   295 LTSLNIKAGDIITVLEQHSDGRWKGCIHDNRTGNDRVGYFPSNMVEVIKRAGPSTQQYLKIHIRP 359

  Fly   337 -------QANGLSHSLSSLDIFAKPPENYLQMKPIIHQKSCDNMSDFRTNGSNLLT----SYKPV 390
                   ..||.|..:.||.:...||    ...|:.||..      |.:.|.|:.|    .::|.
Zfish   360 PAIGSVIMVNGDSSHIFSLPLTPPPP----PALPLTHQPL------FTSFGYNMPTCSTIGFEPA 414

  Fly   391 YKQPMLPSFRMDSDISNGSV------------PSRSYEYINLLR--------------NGSHSDD 429
            ......|  :.|:. |.|||            .|.:.|.|.:||              .||.|..
Zfish   415 SSCSEEP--QKDTG-SRGSVSSPHGSPTLSGQQSGANEEIWVLRKPLAAGGSVGSMGSTGSLSGR 476

  Fly   430 NSASTSSNSAVRQQAVATYVEMKLPTPPVPKPRTRINGEYNDYANVVPIE---EGSCVAAVDNNN 491
            :|||..|::|   .|..|...:.:||.|...|....:|     .||..:.   ||..:.|...:.
Zfish   477 SSASGQSSNA---NAHLTNSPVPVPTTPTHSPGVNTHG-----LNVPGLHAQAEGVKLLATVLSQ 533

  Fly   492 NSNGNGTKLRLVRHSPTPDYP-------PPTVTEAERTIFN--FMQPATLRKN-SLLEPAESPRT 546
            ::.   .|..|:..|.:...|       |.:|:...|....  |:.|...||: :..|...|...
Zfish   534 SAK---AKEHLMDQSQSVSDPNSASPQRPQSVSAVPRQQRKKPFVDPLLQRKDEASAESKSSEAV 595

  Fly   547 TNSVSSDQVEEYVADIPFAGLFKGSTLNLSSDVVDGIGAV-PGDREFLQSPSMVRSAHVQNHRRS 610
            ...::|.|::.|..:...||....:...::.:.:..||.. ||.|:     .|:......|....
Zfish   596 VEWLTSAQLQFYTTNFLTAGYDLQTISRMTPEDLTAIGVTKPGHRK-----KMLSEISKMNIPDW 655

  Fly   611 LSKQRYSALGEDFSASRVWAEIDTIFENIGNEVSTVEQEVEEFVEDPSSLSLEDSRQ 667
            :.:::.|:|.|..||..:.....|:.:|..:.:        :|:.|   ::|||.::
Zfish   656 IPQEKPSSLAEWLSAIGLNQYYQTLVQNGYDNM--------DFISD---ITLEDLKE 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	21/62 (34%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK	43..171	CDD:238125	53/127 (42%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..148	CDD:289560	37/94 (39%)
		ANK repeat	81..115	CDD:293786	13/33 (39%)
		ANK	112..254	CDD:238125	56/141 (40%)
		ANK repeat	117..148	CDD:293786	11/30 (37%)
		Ank_2	122..230	CDD:289560	38/107 (36%)
		ANK repeat	204..232	CDD:293786	12/27 (44%)
		Ank_5	221..273	CDD:290568	25/51 (49%)
		ANK repeat	234..264	CDD:293786	16/29 (55%)
		PTB_Anks	688..857	CDD:269972
si:dkeyp-9d4.3	XP_009304428.1	Ank_4	7..69	CDD:290365	21/61 (34%)
		ANK repeat	7..46	CDD:293786	10/38 (26%)
		ANK	43..168	CDD:238125	53/127 (42%)
		ANK repeat	48..79	CDD:293786	12/30 (40%)
		Ank_2	53..145	CDD:289560	37/94 (39%)
		ANK repeat	81..112	CDD:293786	13/33 (39%)
		ANK	109..238	CDD:238125	56/141 (40%)
		ANK repeat	114..145	CDD:293786	11/30 (37%)
		Ank_2	119..215	CDD:289560	39/108 (36%)
		ANK repeat	148..183	CDD:293786	13/34 (38%)
		ANK repeat	185..216	CDD:293786	15/43 (35%)
		Ank_5	205..258	CDD:290568	27/67 (40%)
		ANK repeat	218..248	CDD:293786	16/29 (55%)
		SH3	281..342	CDD:302595	4/60 (7%)
		Caskin1-CID	449..533	CDD:293208	24/91 (26%)
		SAM	587..650	CDD:197735	13/67 (19%)
		SAM_caskin1,2_repeat1	590..654	CDD:188896	13/68 (19%)
		SAM_caskin1,2_repeat2	655..722	CDD:188897	12/58 (21%)
		SAM	661..723	CDD:197735	12/52 (23%)
		Caskin-tail	1501..1558	CDD:293238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810