DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11168 and anks1a

DIOPT Version :9

Sequence 1:	NP_001262939.1	Gene:	CG11168 / 42981	FlyBaseID:	FBgn0039249	Length:	863	Species:	Drosophila melanogaster
Sequence 2:	XP_031751496.1	Gene:	anks1a / 100127665	XenbaseID:	XB-GENE-5796908	Length:	1081	Species:	Xenopus tropicalis

Alignment Length:	1122	Identity:	308/1122 - (27%)
Similarity:	446/1122 - (39%)	Gaps:	359/1122 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKDQHLLEASRAGDIKTVDKLLEHSSKR----------------------HGPLSSFR---RSP 40
            |||:|.||||:|.|:...|::||  ..||                      :.||||..   |.|
Frog     1 MGKEQELLEAARTGNRAAVERLL--GGKRLSGAGPGGANVGGVGLTGGVASNHPLSSLLSIWRGP 63

  Fly    41 SINCQDMNGYTSLHHACLNGHSNIVRLLLSHNALLDVPDIRGSTPLFLAAWAGHQDIVKMLLMHS 105
            ::||.|.:|||.||||.||||.::|.:||.:.|:.::.|.:|..||.||||.|...||::|:.|.
Frog    64 NVNCVDSSGYTPLHHASLNGHKDVVEILLRNEAVTNIADCKGCFPLHLAAWKGDAHIVRLLIHHG 128

  Fly   106 PTGANPNAQTI------------------ENETPLHSGAQHGHNAVVAILLSYGADPAIRNNSFQ 152
            |:.|..|.|.:                  :|||.||..||:||..||.:||....||.:|||..:
Frog   129 PSHAKVNEQNVPEVKKYGPFHPYVNAKNNDNETALHCAAQYGHTDVVRVLLEELTDPTMRNNKLE 193

  Fly   153 TALDLAAQFGRLQVVQTLLRVYPDLILPYKRLEDDNEELLGCMPIKHIFTHTCLHLASRNGHKKV 217
            |.|||||.:|||:||:.||..:|:              ||.|    |...||.||||:|||||.|
Frog   194 TPLDLAALYGRLEVVKLLLIAHPN--------------LLSC----HTRKHTPLHLAARNGHKAV 240

  Fly   218 VETLLAAGVDVNILTNAGSALHEAALCGKKSVVVTLLKAGIYVHATDGNGRTALDILSDYPPHVT 282
            |:.||.:.:|:|..|..|||||||||.||..||:.||.:||.|..||..|.|||||:.:.|...:
Frog   241 VKVLLDSSMDINYQTEKGSALHEAALFGKTDVVLMLLNSGIDVSITDNKGMTALDIVQELPSQKS 305

  Fly   283 YDIVGAINEFTQAAREH-QKPLV---------VENG------------------TQSLPKRLYEK 319
            ..|...|.:.:...:|. |.|::         ::.|                  |:|..:.|:..
Frog   306 KQIAALIKDHSSVRKEQKQIPVMPAPSSLDIEIQGGGISRALVDIQLDLDNLSQTESPYEALFNA 370

  Fly   320 NS-----------------------QRQKVPPRQRK---KQDHQANG-------LSHSLSSLDIF 351
            :|                       :|::.||...|   ::|.:...       :|.:|.|..|
Frog   371 SSCHSLDSICSERSSDSLSYEAAGARRKERPPPPAKPPPEEDEELESSRERGVTVSETLISAQI- 434

  Fly   352 AKPPENYLQMKPIIHQKSCDNMSDFRTNGSNLLT--SYKPVYKQPMLPSFRM------DSDISNG 408
            .:..||..::......|..|:..:........::  ..:|.:..|.....|.      .||:|:|
Frog   435 CQEEENPYELLVTAETKRLDSRGERHLQEICCISQPQVRPRHNAPPQDQVRSSLNRHGSSDLSSG 499

  Fly   409 ------------------------------SVPSRSYEYINLLRNGSH-----------SDDNSA 432
                                          |..|...::.:.|.:||.           .:.:|.
Frog   500 HSEGESHGSERPNSGQRRSSSGGWSLASADSCDSHMLQHFSGLLHGSSPVCETKDPPLACEPSSI 564

  Fly   433 STSSNSAVRQQAVATYVEMKLP---------------TPPVPKPRTRINGEYNDYANVVPIEEGS 482
            ...||.||        ..|:||               :||     :..||:  |:.....:...|
Frog   565 EGCSNGAV--------AHMELPLRRSLSKSDSDLLTCSPP-----SGTNGD--DWNRSESLTNCS 614

  Fly   483 CVAA------------------------------VDNNNNSNGNGTKLRLVRHSPTPDYPPPTVT 517
            .||.                              :|...:|.|.|.:....:...|..|.|
Frog   615 TVAGKRSLEKSPSFTSEWDEQHHLWAPTTTPKQHIDKIMSSIGQGIEFSQEQQFITGSYVP---- 675

  Fly   518 EAERTIFNFMQPATLRKNSLLEPAESPRTTNSVSSDQVEEYVADIPFAGLFKGSTLNLSSDVVD- 581
              |:::..:     |:...||: .||....|..  |.| .::||          |:....|::|
Frog   676 --EQSVAQW-----LKSIGLLQ-YESKLVLNGF--DDV-RFLAD----------TMMDDQDLLDI 719

  Fly   582 GIGAVPGDREFL---QS-------------PSMVRSAHVQNHRRSLSKQRYSALGEDFSASRVWA 630
            ||..:....:.|   ||             ||.:||..:..:..:.....||::.   :...:|
Frog   720 GITDLQHRHQILRLAQSLPKPPVLSADLSVPSWLRSLALHQYAPNFISSGYSSME---TLRNLW- 780

  Fly   631 EIDTI----FENIGNEVSTVEQEVEEFVEDP-------------------SSLSLEDSRQSLH-- 670
            |::.:    ...:|:....:....|...|||                   |||.|.|....|.
Frog   781 ELEIVNVLKVNLLGHRKRILASLAERPYEDPPQKPPRFSQLRCPDLLSCGSSLVLGDQVTGLESE 845

  Fly   671 --------------------IRDPAELLLGRKPSAASS-----NWCHSPYTFIYGEIRYSLFYLG 710
                                :.:...|.| |.|:..:|     ||.|.|...|:....|...|||
Frog   846 RSWTAGAENTEEHQAILVPAVEEEPRLSL-RPPNVTTSYASLQNWQHQPEKLIFESCGYESSYLG 909

  Fly   711 STVIRKLQGTLSTRKSIQKLKIDENLKSAASVSDFSLLENCTTSTKYLKAANHQTRLNVDIAVSC 775
            |.:||.|:||.||:.:..|::                     .||:.:|...     .:.:::|.
Frog   910 SMLIRDLRGTESTQDACAKMR---------------------KSTEQMKKIP-----RITLSISY 948

  Fly   776 VGVKFIDHDKKTAICCHDIENINCVCQDSEDLRYFAYITKEQDL--HYCHVFMVDSLELAKEIIM 838
            .||||||...:..|..|:|.||:|..||.|||..||||||:...  ||||||....:..|.|||:
Frog   949 RGVKFIDASNQNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTADVNQAYEIIL 1013

  Fly   839 TLGQAFEVAYQLALSRQ 855
            ||||||||||||||..|
Frog  1014 TLGQAFEVAYQLALQAQ 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11168	NP_001262939.1	Ank_4	6..69	CDD:290365	32/87 (37%)
		ANK repeat	7..46	CDD:293786	19/63 (30%)
		ANK	43..171	CDD:238125	64/145 (44%)
		ANK repeat	48..79	CDD:293786	15/30 (50%)
		Ank_2	53..148	CDD:289560	44/112 (39%)
		ANK repeat	81..115	CDD:293786	15/33 (45%)
		ANK	112..254	CDD:238125	69/159 (43%)
		ANK repeat	117..148	CDD:293786	15/30 (50%)
		Ank_2	122..230	CDD:289560	49/107 (46%)
		ANK repeat	204..232	CDD:293786	16/27 (59%)
		Ank_5	221..273	CDD:290568	29/51 (57%)
		ANK repeat	234..264	CDD:293786	18/29 (62%)
		PTB_Anks	688..857	CDD:269972	71/175 (41%)
anks1a	XP_031751496.1	Ank_2	<61..>217	CDD:423045	68/155 (44%)
		ANK repeat	71..102	CDD:293786	15/30 (50%)
		ANK repeat	104..156	CDD:293786	16/51 (31%)
		ANK repeat	158..189	CDD:293786	15/30 (50%)
		ANK repeat	191..222	CDD:293786	17/48 (35%)
		Ank_2	196..287	CDD:403870	53/108 (49%)
		ANK repeat	224..254	CDD:293786	17/29 (59%)
		ANK repeat	257..287	CDD:293786	18/29 (62%)
		SAM_AIDA1AB-like_repeat1	675..741	CDD:188898	20/90 (22%)
		SAM_AIDA1AB-like_repeat2	746..806	CDD:188899	9/63 (14%)
		PTB_Anks	887..1032	CDD:269972	70/170 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	107	1.000	Domainoid score	I6424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1567
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252573at33208
OrthoFinder	1	1.000	-	-		FOG0003340
OrthoInspector	1	1.000	-	-		mtm9472
Panther	1	1.100	-	-	O	PTHR24174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.070