Protein Alignment PIG-S and PIGS

DIOPT Version :9

• Sequence 1: NP_733060.1
• Gene: PIG-S / 42979
• FlyBaseID: FBgn0265190
• Length: 536
• Species: Drosophila melanogaster
• Sequence 2: NP_149975.1
• Gene: PIGS / 94005
• HGNCID: 14937
• Length: 555
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 159/575 - (27%)
• Similarity: 255/575 - (44%)
• Gaps: 115/575 - (20%)

  Fly    25 ATLAFIVVIIGIGVPMWWRTTTVYRVNLPSTEILSLSKIPIKTAVQV-AIYTQQTSRGQLLIAEL 88
            |.|.|..|.|.:|:|:||:||..||.:||.::|..|:.:.::..|.| .::|::
Human    19 AALFFAAVAIVLGLPLWWKTTETYRASLPYSQISGLNALQLRLMVPVTVVFTRE----------- 72

  Fly    89 QNAFSDNEIWSVEFKQLSPTPMT-------------------QEAHTPAA--LEKLLLENHVQSV 132
                      ||........|.|                   |:|:..|.  .|:.|....||..
Human    73 ----------SVPLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALDHEEEALSSGSVQEA 127

  Fly   133 GDFMFIEWPKLQEELLLT----TERSALMRSDTPS-----------------------NKIAQLL 170
            .  ..::.|:.|.|..||    :|.|:|:..|..|                       .:|.|:.
Human   128 E--AMLDEPQEQAEGSLTVYVISEHSSLLPQDMMSYIGPKRTAVVRGIMHREAFNIIGRRIVQVA 190

  Fly   171 HAKILQTYRINQILS---TDERMGAKSEAPQPA---YDVIVSVLNPKPRLTHAKWNIAMAVKTYI 229
            .|..|....:...|:   .:::..|:...|..:   |::..|:|||.|:.....|:|..||:.|:
Human   191 QAMSLTEDVLAAALADHLPEDKWSAEKRRPLKSSLGYEITFSLLNPDPKSHDVYWDIEGAVRRYV 255

  Fly   230 EPWLAKVSGVSNYTVRSQWKYRVAIEADLKQVRDQSKLGRHYALQETALPHLLTSIAQNLSASTT 294
            :|:|..:....|::|.||..|...:..:   .|..|....:| |...:|||::..:...|.:|..
Human   256 QPFLNALGAAGNFSVDSQILYYAMLGVN---PRFDSASSSYY-LDMHSLPHVINPVESRLGSSAA 316

  Fly   295 D-KPAINLVVYIPPCHIAPLHIYNSKDQRLTRNDVDAFISPPWGGFIIANPPEHVCLAAMSDQEA 358
            . .|.:|.::|:|....:||:|.:.....:..|   ||.||.|||.::.|.......|::.   .
Human   317 SLYPVLNFLLYVPELAHSPLYIQDKDGAPVATN---AFHSPRWGGIMVYNVDSKTYNASVL---P 375

  Fly   359 VPYHVSTTDNMQVMLDQLHKLLDISSELQMEGVKVVDIEQLEPR------------RWEYEAYLR 411
            |...|.....|:|.|.||..|..|:.            .||.|:            .||.:..|.
Human   376 VRVEVDMVRVMEVFLAQLRLLFGIAQ------------PQLPPKCLLSGPTSEGLMTWELDRLLW 428

  Fly   412 RSAIRHISTASSTLQSLIKLLDQISYIVIDDEVGAAITNSYADILAAKAALLEHRLADASVLAKR 476
            ..::.:::||::||.||.:||.:||.|||.|:|.:.:..:.|.:..:...|....||.|.|.::.
Human   429 ARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYKAVAAVQKSAEELASGHLASAFVASQE 493

  Fly   477 AFVASERGFFDASLLAQLYFPDEQKYAIYIPLFLPIMVPVLSSFNMLRGVLQARR 531
            |..:||..|||.|||..|||||:||:|||||||||:.||:|.|  :::..|:.|:
Human   494 AVTSSELAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLS--LVKIFLETRK 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIG-S	NP_733060.1	PIG-S	28..521	CDD:287481	155/560 (28%)
PIGS	NP_149975.1	PIG-S	22..550	CDD:287481	157/572 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144805
Domainoid	1	1.000	180	1.000	Domainoid score	I3525
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41963
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3990
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46691
OrthoDB	1	1.010	-	-		D1399804at2759
OrthoFinder	1	1.000	-	-		FOG0004772
OrthoInspector	1	1.000	-	-		oto88868
orthoMCL	1	0.900	-	-		OOG6_103860
Panther	1	1.100	-	-	LDO	PTHR21072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R923
SonicParanoid	1	1.000	-	-		X3925
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.940