DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-S and GPI17

DIOPT Version :9

Sequence 1:	NP_733060.1	Gene:	PIG-S / 42979	FlyBaseID:	FBgn0265190	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_010722.3	Gene:	GPI17 / 852044	SGDID:	S000002842	Length:	534	Species:	Saccharomyces cerevisiae

Alignment Length:	557	Identity:	124/557 - (22%)
Similarity:	213/557 - (38%)	Gaps:	118/557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 FIVVIIGIGVPMWWRTTTVYRVNLPSTEILSLSK---------IPIKTAVQVAIYTQQTSRGQLL 84
            |:.:.:.:|||:|::.|||||.:||...|.||..         ||:........:.......|:.
Yeast    14 FVAIYLFLGVPLWYKLTTVYRASLPINYIESLQNNKFQDIHLVIPVYVKSDTYRFPDVHDAIQVQ 78

  Fly    85 IAELQNAFSDNEIWSVEFKQLSPTPMTQEAHTPAALEKLLLENHVQSVGDFMFIEWPKLQE---- 145
            :..|.|:......||:   |:.|...|.|              .::|.|:...:...||.|
Yeast    79 VNHLLNSQEQRVPWSL---QVLPYNETIE--------------QMESEGNQFHVVTLKLDEFIGY 126

  Fly   146 -------ELLLTTERSALMRSDTPSNKIAQLL--HAKILQTYRINQILSTDERMGAKSEAP---Q 198
                   |.|:..:.:|::.:|.|. .:||.|  |...|:...:|:   |.|.:...::..   .
Yeast   127 SSAYDTKETLVYYDDAAVLSNDLPF-FVAQTLVEHTFQLEWTHLNK---TCEGVSTNNDVAISYD 187

  Fly   199 PAYDVIVSVL----NPKPRLTHAKWNIAMAVKTYIEPWLAKVSGVSNYTVRSQWKYRVAIEADLK 259
            |...:.|::|    ||      ..|.|...:..|..|:...:|.:.|:||.|...|.       .
Yeast   188 PNIHLSVTLLSGDGNP------VAWEIEPTLTDYFSPFRKFLSPLVNFTVDSSIVYH-------N 239

  Fly   260 QVRDQSKLGRHYALQETALPHLLTSIAQNLSASTTDKPAINLVVYIPPCHIAP--LHIYNSK--D 320
            .:...|..|...::....|.|.:.....:..|...:..|:||.:..|....:|  |...|..  .
Yeast   240 DLNLHSLNGSCTSVTWFDLSHTIDLSELSSMAYYPEDSALNLAIVFPSASSSPDGLAFINGTRIS 304

  Fly   321 QRLTRNDVDAFISPPWGGFIIANPPEHVCLAAMSDQEAVPYHVSTTDNMQVMLDQLHKLLDISSE 385
            ..:|..|.::::.|.||..||...|            ..|..|.:.|.::.|:.:.  ..||
Yeast   305 DEITTLDWNSYLVPQWGVIIINKMP------------LKPNSVISEDYLEPMMYRF--ATDI--- 352

  Fly   386 LQMEGVKVVDIEQLEPRRWEY---EAYLRRSAIRHISTASSTLQSLIKLLDQISYIVIDDEVGAA 447
            .|:.|:.....:.|.|    |   :::.|.:.::::..|:.||.||:||..|...:.|..||...
Yeast   353 FQLLGLTEGSQDLLSP----YITIDSFKRLTILQNLDKATETLWSLVKLTQQFQGMSIPREVSDN 413

  Fly   448 ITNSY----------------ADILAAKAALLEHRLADASVLAKRAFVASERGFFDASLLAQLYF 496
            :..:.                .||:...|..|.:.|..          ..|:.||:..::.|.:|
Yeast   414 VIEALDLRLQIIDLLNDPGKGGDIVWNNALHLSNELVK----------LCEKAFFNGEMVQQNFF 468

  Fly   497 PDEQKYAIYIPLFLPIMVPVLSSF-NMLRGVLQARRK 532
            |.|...|:|:||..||...:...| |:::...|..:|
Yeast   469 PQEHMIAVYLPLLGPISAVMFFGFYNVMKEKNQKSKK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-S	NP_733060.1	PIG-S	28..521	CDD:287481	121/544 (22%)
GPI17	NP_010722.3	PIG-S	13..502	CDD:402233	122/552 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343074
Domainoid	1	1.000	80	1.000	Domainoid score	I2033
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41963
Inparanoid	1	1.050	80	1.000	Inparanoid score	I1620
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004772
OrthoInspector	1	1.000	-	-		oto99174
orthoMCL	1	0.900	-	-		OOG6_103860
Panther	1	1.100	-	-	LDO	PTHR21072
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R923
SonicParanoid	1	1.000	-	-		X3925
TreeFam	0	0.000	Not matched by this tool.
	12	11.920