DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-S and Pigs

DIOPT Version :9

Sequence 1:	NP_733060.1	Gene:	PIG-S / 42979	FlyBaseID:	FBgn0265190	Length:	536	Species:	Drosophila melanogaster
Sequence 2:	NP_001006602.1	Gene:	Pigs / 303277	RGDID:	1359436	Length:	555	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	160/580 - (27%)
Similarity:	258/580 - (44%)	Gaps:	117/580 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ATLAFIVVIIGIGVPMWWRTTTVYRVNLPSTEILSLSKIPIKTAVQVAIYTQQTSRGQLLIAELQ 89
            |.|.|..|.|.:|:|:||:||..||..||.:||..|:.:.::..|.|.:
  Rat    19 AALFFAAVAILLGLPLWWKTTETYRAPLPYSEISGLNALQLRLMVPVTV---------------- 67

  Fly    90 NAFSDNEIWSVEFKQLSPTPMTQEAHTP----------------AALEKLLLENHVQSVGDF--- 135
             .|:.:.: .::.::..|..:..|...|                .|||.   |....|:|..
  Rat    68 -VFTRDSV-PLDDQEKLPFTVVHEREIPLKYKMKIKCRFQKAYRRALEH---EEEALSLGSVHEA 127

  Fly   136 -MFIEWPKLQEELLLT----TERSALMRSDTPS-------------------NKIA-QLLH---- 171
             ..:..|:.|.|..||    :|.|:|:..|..|                   |.|. :::|
  Rat   128 EALLAEPEKQAEGSLTVYVISEHSSLLPQDMMSYIGPERTAIVRGMIHREAFNIIGRRIIHVAQA 192

  Fly   172 --------AKILQTYRINQILSTDERMGAKSEAPQPAYDVIVSVLNPKPRLTHAKWNIAMAVKTY 228
                    |..|..:......|:|:|...||..   .|::..|:|||.|:.....|:|...|:.|
  Rat   193 MSLTEDVLAAALADHLPEDKWSSDKRRPLKSSL---GYEITFSLLNPDPKSHDVHWDIEEGVQRY 254

  Fly   229 IEPWLAKVSGVSNYTVRSQWKYRVAIEADLKQVRDQSKLGRHYALQETALPHLLTSIAQNLSAST 293
            ::|:|.::|...|::|.||..|...:..:.:.....|.    |:|...:|||::..:...|.:|.
  Rat   255 VQPFLNRLSAAGNFSVDSQILYYAMLGVNPRFDPASSS----YSLAMHSLPHVINPVESRLGSSA 315

  Fly   294 TD-KPAINLVVYIPPCHIAPLHIYNSKDQRLTRNDVDAFISPPWGGFIIANPPEHVCLAAMSDQE 357
            .. .|.:|.::|:|....:||:|.:.....:..|   ||.||.|||.::.|....:..|:   :.
  Rat   316 ASLYPVLNFLLYVPELAHSPLYIQDKDGAPVATN---AFHSPRWGGIMVYNVDPKIYNAS---EL 374

  Fly   358 AVPYHVSTTDNMQVMLDQLHKLLDISSELQMEGVKVVDIEQLEPR------------RWEYEAYL 410
            .|...|.....|:|.|.||..|..|:.            .|:.|:            .||.:..|
  Rat   375 PVRVEVDMAQVMEVFLAQLRLLFGIAQ------------PQVPPKCLLSGPKSEGLMTWELDRLL 427

  Fly   411 RRSAIRHISTASSTLQSLIKLLDQISYIVIDDEVGAAITNSYADILAAKAALLEHRLADASVLAK 475
            ...::.:::||::||.||.:||.:||.|||.|:|.:.:..:.|.:..|..||....|:.|...::
  Rat   428 WARSVENLATATTTLTSLAQLLGKISNIVIKDDVASEVYRAVAAVQKAAEALALGHLSSAFAASQ 492

  Fly   476 RAFVASERGFFDASLLAQLYFPDEQKYAIYIPLFLPIMVPVLSSFNMLRGVLQARRKEKQ 535
            .|..:|||.|||.|||..|||||:||:|||||||||:.||:|.|  :::..|:..:..|:
  Rat   493 EAVTSSERAFFDPSLLHLLYFPDDQKFAIYIPLFLPMAVPILLS--LVKIFLETHKSWKK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-S	NP_733060.1	PIG-S	28..521	CDD:287481	156/561 (28%)
Pigs	NP_001006602.1	PIG-S	22..550	CDD:287481	157/575 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338502
Domainoid	1	1.000	187	1.000	Domainoid score	I3247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41963
Inparanoid	1	1.050	189	1.000	Inparanoid score	I3807
OMA	1	1.010	-	-		QHG46691
OrthoDB	1	1.010	-	-		D1399804at2759
OrthoFinder	1	1.000	-	-		FOG0004772
OrthoInspector	1	1.000	-	-		oto95997
orthoMCL	1	0.900	-	-		OOG6_103860
Panther	1	1.100	-	-	LDO	PTHR21072
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3925
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910