DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10845 and kif5ab

DIOPT Version :9

Sequence 1:	NP_651309.2	Gene:	CG10845 / 42978	FlyBaseID:	FBgn0039246	Length:	463	Species:	Drosophila melanogaster
Sequence 2:	XP_009301044.1	Gene:	kif5ab / 799274	ZFINID:	ZDB-GENE-110510-3	Length:	1050	Species:	Danio rerio

Alignment Length:	550	Identity:	124/550 - (22%)
Similarity:	204/550 - (37%)	Gaps:	169/550 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 RVYLFRKLLTSPTD-LQLEVSAEAISEVLDQVLGGRISTVFSCGRIPFN---------HGADPSD 70
            |.|:|.|:.  ||: .|.:|......:::..||.|...|:|:.|:....         |.|:...
Zfish    45 RSYVFDKVF--PTNCTQEQVYNTCAQQIVKDVLDGYNGTIFAYGQTSSGKTYTMEGKLHDANGRG 107

  Fly    71 VVSRILNELFTRIYELETNMEVHVSVRYVQLN-----------------GETNDLVVNLKGCNRR 118
            ::.||..::|..||.::.|:|.|:.|.|.::.                 .|..:.|..:|||..|
Zfish   108 IIPRIAEDIFNHIYTMDENLEFHIKVSYFEIYMDKIRDLLDVTKTNLSVHEDKNRVPYVKGCTER 172

  Fly   119 TTRDHFVATSHGVHAYIARVMDKVAEG--------------GDCPHLIFTVHVKQTNGDQLRKCC 169
                 ||::..       .|||.:.||              ....|.||.:::||.:.:..:|.|
Zfish   173 -----FVSSPE-------EVMDLIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQEHVETEQKLC 225

  Fly   170 GRLQLVHLQQLTEDSPPLESDTPLD----------TLISLFQVLANSPKTHIRYYNIRLTRLLNQ 224
            |:|.||.|....:.|........||          .|.::...||...|||:.|.:.::||:|..
Zfish   226 GKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQD 290

  Fly   225 LMGNGSRTVIINYADPPEGKDDPVTPAPTPSS-----------NS---NASLPDEVWRRLLRQER 275
            .:|...||.:.....|....|     |.|.|:           ||   |..|..|.|:|...:|:
Zfish   291 SLGGNCRTTMFICCSPSAYND-----AETKSTLMFGQRAKTIMNSASVNLELTAEQWKRKYEKEK 350

  Fly   276 AKYRCLRNKALGIVVDKEELERFLESLE---------------------ASDSSEEDISDGDFEQ 319
            .|     ||.|     ||.::|....|.                     ..|::.::.|.|..|.
Zfish   351 EK-----NKDL-----KESMQRLEAELNHWRNGESVVLITPVSPAECDVTEDTAVDNQSHGQTEL 405

  Fly   320 KVEQKMLAIRSEAEMSIKKLKGLQMDIDYLTERNCHLEQQLDQKNSQLNMQSNLMLSIHMELRDQ 384
            ..||.    .|..|..|::                 |.:|||.|:.::|:|..|:..:..::.||
Zfish   406 IPEQH----NSRYEEEIQQ-----------------LYRQLDDKDDEINLQCQLVEKLKEQMLDQ 449

  Fly   385 -----------------TRKFQD-------KIAEYTDKFQEM---WERQRLDIQYNEQRQLRQLT 422
                             .|:.|.       ::.|.....:|:   ::.:.|:.|.| .|..|:||
Zfish   450 EELLACARADLERVQCDVRRLQADSESSKLEVQEVLQALEELALSYDHKSLEAQDN-SRHNRRLT 513

  Fly   423 KLFDSLCQATQRWLHRKT--SRLPQKDADE 450
               :.|...|...|..::  |||.:.:..:
Zfish   514 ---EELAHTTSALLSLESDFSRLQEVNGQQ 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10845	NP_651309.2	Motor_domain	16..236	CDD:277568	67/270 (25%)
kif5ab	XP_009301044.1	KISc_KHC_KIF5	7..327	CDD:276820	72/300 (24%)
		KISc	9..334	CDD:214526	74/307 (24%)
		DUF2570	847..964	CDD:305162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900