DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and YOL075C

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_014567.2	Gene:	YOL075C / 854080	SGDID:	S000005435	Length:	1294	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	138/552 - (25%)
Similarity:	252/552 - (45%)	Gaps:	71/552 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGA------TRGQVLLNGSPLSKALFQQR 94
            :|:.||.....|.:.||:|..||||.:||::||.|...:      |.|.::.|...:|:.:|:..
Yeast   709 ILQSVNAIFKPGMINAIMGPSGSGKSSLLNLISGRLKSSVFAKFDTSGSIMFNDIQVSELMFKNV 773

  Fly    95 CGYVTQSCT-FVPGLTVAQTLHYTPTILSGYL----KSSKVRQVLADLALSQ-----VAHKRVEY 149
            |.||:|... .:..|||.:||.|...:...:|    :..:...::..|.|..     :.::.|:.
Yeast   774 CSYVSQDDDHLLAALTVKETLKYAAALRLHHLTEAERMERTDNLIRSLGLKHCENNIIGNEFVKG 838

  Fly   150 LNISEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDV 214
            ::..|.||:.:|:||:.||.:|||||||.|||..::..::.||....::.|..|::::.:|||::
Yeast   839 ISGGEKRRVTMGVQLLNDPPILLLDEPTSGLDSFTSATILEILEKLCREQGKTIIITIHQPRSEL 903

  Fly   215 FPFLDRALFLCLGG-VVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQ 278
            |......|.|...| ..::|....|:.||..:|:.||...|...::|.|.:|:.::....:.|..
Yeast   904 FKRFGNVLLLAKSGRTAFNGSPDEMIAYFTELGYNCPSFTNVADFFLDLISVNTQNEQNEISSRA 968

  Fly   279 QIEALVERFSRE--------TPISDAPLNNMGSGKVPLA--YGKPGELKVWVMLYLKLLASTFSC 333
            ::|.::..:...        ||||:....:..|.....:  ..||..|   |:.|:..:...|:.
Yeast   969 RVEKILSAWKANMDNESLSPTPISEKQQYSQESFFTEYSEFVRKPANL---VLAYIVNVKRQFTT 1030

  Fly   334 GLVGMKTLFLRLLLLPLALSILWA-FYTDVGDDSHGFFTKNGMILNILGLS------YGCGILTT 391
            ......:|..|:..:| .|.:::| |:..|   .|.:.:    |.|.|||:      |..|:|..
Yeast  1031 TRRSFDSLMARIAQIP-GLGVIFALFFAPV---KHNYTS----ISNRLGLAQESTALYFVGMLGN 1087

  Fly   392 ISLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVFAY 456
            ::.:|..|..|.::..:.:|......:||.::.:|.||:::|:.: |...|...:....|..||
Yeast  1088 LACYPTERDYFYEEYNDNVYGIAPFFLAYMTLELPLSALASVLYA-VFTVLACGLPRTAGNFFA- 1150

  Fly   457 LLVALWSSFVL---AEQLTIAFLLVVKVPFNAAIAVTYVLVISIALA-------SGTVRSFKGLQ 511
               .::.||::   .|.|.|......:.|......::.:|.|...::       |..::.|..|.
Yeast  1151 ---TVYCSFIVTCCGEALGIMTNTFFERPGFVVNCISIILSIGTQMSGLMSLGMSRVLKGFNYLN 1212

  Fly   512 PWLQDNTKGTHTRYASSLLHSIAFQSR-KLNC 542
            |          ..|.|.::.:.||... ||.|
Yeast  1213 P----------VGYTSMIIINFAFPGNLKLTC 1234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	64/213 (30%)
		CcmA	31..302	CDD:224054	81/290 (28%)
		ABC2_membrane	364..515	CDD:304374	36/166 (22%)
YOL075C	NP_014567.2	3a01205	55..1236	CDD:273362	138/552 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2367
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.900