DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11069 and ABCG8

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_200098.1	Gene:	ABCG8 / 835363	AraportID:	AT5G52860	Length:	589	Species:	Arabidopsis thaliana

Alignment Length:	516	Identity:	135/516 - (26%)
Similarity:	237/516 - (45%)	Gaps:	91/516 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ALVLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGATRGQVLLNGSPLSKALFQQRCGYV 98
            :.:|:.:.||.|..|::|::|..|:||..|||:::.:. ..|.|.:|||..|::.:.:::...||
plant    42 SFILRNITLTAHPTEILAVVGPSGAGKSTLLDILASKT-SPTSGSILLNSIPINPSSYRKISSYV 105

  Fly    99 TQSCTFVPGLTVAQTLHYTPTIL--SGYLKSSKVRQVLADLALSQVAHKRV-EYLNISEARRLAI 160
            .|..:|.|.|||::|..:...:|  :..:.|..|..:|::|.|:.::|.|: :.|:..|.||::|
plant   106 PQHDSFFPLLTVSETFSFAACLLLPNPSIVSETVTSLLSELNLTHLSHTRLAQGLSGGERRRVSI 170

  Fly   161 GIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFLDRALFLC 225
            |:.|:.||..|||||||.|||..||:.:|.||.:.|......::||:.:|...:...:||.|.|.
plant   171 GLSLLHDPCFLLLDEPTSGLDSKSAFDVIHILKSIAVSRQRTVILSIHQPSFKILSIIDRLLLLS 235

  Fly   226 LGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYL----------------CLSTVDRRSRDRFL 274
            .|.|||.|...::..:....||..|...|.|.|.:                .|.:::.|.:
plant   236 KGTVVYHGRLDSLEGFLLFKGFTVPPQLNSLEYAMEILQELRESDGNTDATALPSIENRKQ---- 296

  Fly   275 ESSQQIEALVE-RFSRETPISDAPLNNMGSGKVPLAYGKPGELKVWVMLYLK---LLASTFSCGL 335
               ::.:::|. |.||.|.||            .||      .:.|.::|..   ||.:.....:
plant   297 ---REKQSIVRYRKSRITEIS------------LLA------RRFWKIIYRTRQLLLTNALEALV 340

  Fly   336 VGMKTLFLRLLLLPLALSILWAFYTDVGDDSHGFFTKNGMI---LNILGLSYGCGILTTISLFPI 397
            ||:               :|...|.::|....|...:.||.   |..|       :.:|....||
plant   341 VGL---------------VLGTIYINIGIGKAGIEKRFGMFAFTLTFL-------LSSTTETLPI 383

  Fly   398 W---RKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNG-----TVF 454
            :   |....::|..|:|..::.::|...|.:|:..|.::|.|..||.|:       |     ..|
plant   384 FINERPILLRETSSGIYRLSSHILANTLVFLPYLFVISIIYSVSVYFLI-------GLCPTWQAF 441

  Fly   455 AYLLVALWSSFVLAEQLTIAFLLVVKVPFNAAIAVTYVLVISIALASGTVRSFKGL-QPWL 514
            .|.::.:|...::|... :.||..:...:....::..:|:.:..|.||...|.:.| :.||
plant   442 GYFVLVIWIILLMANSF-VLFLSSLAPNYITGTSLVTILLAAFFLFSGYFISKESLPKYWL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	72/201 (36%)
		CcmA	31..302	CDD:224054	88/287 (31%)
		ABC2_membrane	364..515	CDD:304374	36/163 (22%)
ABCG8	NP_200098.1	P-loop_NTPase	29..243	CDD:304359	72/201 (36%)
		3a01204	44..584	CDD:273361	135/514 (26%)
		ABC2_membrane	316..519	CDD:279410	47/222 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920