DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and ABCG4

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_194305.1	Gene:	ABCG4 / 828680	AraportID:	AT4G25750	Length:	577	Species:	Arabidopsis thaliana

Alignment Length:	560	Identity:	151/560 - (26%)
Similarity:	256/560 - (45%)	Gaps:	68/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 AGNSALVLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGATRGQVLLNGSPLSKALFQQR 94
            |...:.:|:.:.||.|..:::||:|..|:||..|||:::.|. ..|.|.:|||...::.:.:::.
plant    24 AEQPSFILRNITLTSHPSQILAIIGPSGAGKSTLLDILAART-SPTSGSILLNSVLINPSSYRKI 87

  Fly    95 CGYVTQSCTFVPGLTVAQTLHYTPTIL--SGYLK-SSKVRQVLADLALSQVAHKRV-EYLNISEA 155
            ..||.|..||.|.|||::|..::.::|  ....| ||.|..:|.:|.|:.:||.|: :.|:..|.
plant    88 SSYVPQHDTFFPLLTVSETFTFSASLLLPKNLSKVSSVVASLLKELNLTHLAHTRLGQGLSGGER 152

  Fly   156 RRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFLDR 220
            ||::||:.|:.||.:|||||||.|||..||:.::.||.:.|......::||:.:|...:...:||
plant   153 RRVSIGLSLLHDPEVLLLDEPTSGLDSKSAFDVVQILKSIATSRERIVILSIHQPSFKILSLIDR 217

  Fly   221 ALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQIEALVE 285
            .|.|..|.:||.|....:..:....||..|...|.|.|              .:|..|.|....|
plant   218 VLLLSKGTIVYHGRLDLLEAFLLSKGFTVPSQLNSLEY--------------AMEILQNIRDPYE 268

  Fly   286 RFSRETPISDAPLNNMGSGKVPLAYGKPGELKVWVMLYLKLLASTFSCGLVGMKTLFLRLLLLPL 350
            ..:...| ...|.:...:.|..:...|...:     ..:.||:|.|...:...:.|.|..:|..|
plant   269 NANIALP-DHCPESKKQNQKQSIVRYKSSRI-----TEISLLSSRFWKIIYRTRQLLLTNILESL 327

  Fly   351 ALS-ILWAFYTDVGDDSHGFFTKNGMI---LNILGLSYGCGILTTISLFPIW---RKKFSQDTPE 408
            .:. :|...|.::|....|...:.|:.   |..|       :.:|....||:   |....::|..
plant   328 VVGLVLGTIYLNIGTGKEGIRKRFGLFAFTLTFL-------LSSTTQTLPIFIDERPILLRETSS 385

  Fly   409 GLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVF-----AYLLVALWSSFVLA 468
            |||..::.::|...|.:|:..:.|:|.|..:|.|:       |..|     ||.::.:|...::|
plant   386 GLYRLSSHILANTLVFLPYLLLIAIIYSVSLYFLV-------GLCFSWQALAYFVLVIWIIVLMA 443

  Fly   469 EQLTIAFLLVVKVPFNAAIAVTYVLVISIALASGTVRSFKGL-QPWLQDNTKGTHTRYA------ 526
            ... :.||..:...:.|..:...:|:.:..|.||...|.:.| :.||.......: :||
plant   444 NSF-VLFLSSLAPNYIAGTSSVTILLAAFFLFSGYFISKESLPKYWLFMYFFSMY-KYALDALLI 506

  Fly   527 --SSLLHS---IAFQSRKLN-CTPTASVICPKPADFMHER 560
              .|.||:   :.|:...:| |..|...:..|  :.:|||
plant   507 NEYSCLHNKCLVWFEEASVNSCLVTGGDVLDK--NGLHER 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	75/206 (36%)
		CcmA	31..302	CDD:224054	87/274 (32%)
		ABC2_membrane	364..515	CDD:304374	36/162 (22%)
ABCG4	NP_194305.1	3a01204	30..572	CDD:273361	150/554 (27%)
		P-loop_NTPase	30..230	CDD:304359	74/200 (37%)
		ABC2_membrane	304..507	CDD:279410	49/218 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920