DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and ABCG2

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_181272.1	Gene:	ABCG2 / 818312	AraportID:	AT2G37360	Length:	755	Species:	Arabidopsis thaliana

Alignment Length:	552	Identity:	148/552 - (26%)
Similarity:	249/552 - (45%)	Gaps:	81/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SDYVLEAHNIFHTTEVDGG----GCFNGAGNSA-----LVLKGVNLTVHSGEVMAILGSKGSGKR 61
            |.:||...::.::.::...    .|...:||.:     ::|.|::.....||:||:||:.||||.
plant    94 SPFVLSFTDLTYSVKIQKKFNPLACCRRSGNDSSVNTKILLNGISGEAREGEMMAVLGASGSGKS 158

  Fly    62 ALLDVISRR-ADGATRGQVLLNGSPLSKALFQQRCGYVTQSCTFVPGLTVAQTLHYT-----PTI 120
            .|:|.::.| |..:.||.:.|||..|..::.:....||.|.....|.|||.:||.::     |..
plant   159 TLIDALANRIAKDSLRGSITLNGEVLESSMQKVISAYVMQDDLLFPMLTVEETLMFSAEFRLPRS 223

  Fly   121 LSGYLKSSKVRQVLADLALSQVA--------HKRVEYLNISEARRLAIGIQLVRDPVMLLLDEPT 177
            ||...|.::|:.::..|.|...|        |:.|   :..|.||::||..::.||::|.|||||
plant   224 LSKKKKKARVQALIDQLGLRSAAKTVIGDEGHRGV---SGGERRRVSIGNDIIHDPIILFLDEPT 285

  Fly   178 HGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFLDRALFLCLGGVVYSGGTRAMLEYF 242
            .|||..|||::|.:|...| ::|..:::|:.:|...:...||:.:||..|..||||....:.::|
plant   286 SGLDSTSAYMVIKVLQRIA-QSGSIVIMSIHQPSYRIMGLLDQLIFLSKGNTVYSGSPTHLPQFF 349

  Fly   243 HGIGFPCPQLENPLMYYLCL------STVDRR-------------------SRDRFLESSQQIEA 282
            .....|.|:.||...:.|.|      ||...:                   :..|....|...||
plant   350 SEFKHPIPENENKTEFALDLIRELEYSTEGTKPLVEFHKQWRAKQAPSYNNNNKRNTNVSSLKEA 414

  Fly   283 LVERFSRETPISDAPLNNMGSGKVP--LAYGKPGELKVWVMLYLKLLASTFSCGLVGMKTLFLRL 345
            :....||...:|.| .||..|...|  ..:..|..:::.|:....:|.|.....|:||     ||
plant   415 ITASISRGKLVSGA-TNNNSSNLTPSFQTFANPFWIEMIVIGKRAILNSRRQPELLGM-----RL 473

  Fly   346 LLLPLALSILWAFYTDVGDDSHGFFTKNGMILNILGLS-YGCGILTTISLFPIWRKKFSQDTPEG 409
            ..:.:...||...:|::.:...|...:.|.....:..: |.|.  ..|.:|...|..|.::|...
plant   474 GAVMVTGIILATMFTNLDNSPKGAQERLGFFAFAMSTTFYTCA--EAIPVFLQERYIFMRETAYN 536

  Fly   410 LYSGTTLLIAYNSVSIP-FSAVSAVIASCVVYPLLLDVKYNNGTVFAY--LLVALW--SSFV--- 466
            .|..::.:::.:.:||| ...:||..|:...:.:.|| ...||..|.|  :|.:.|  ||||
plant   537 AYRRSSYVLSQSIISIPALIVLSASFAATTFWAVGLD-GGANGFFFFYFTILASFWAGSSFVTFL 600

  Fly   467 --LAEQLTIAFLLVVKVPFNAAIAVTYVLVIS 496
              :...:.:.|.:||.:       :.|.|:.|
plant   601 SGVIPNVMLGFTVVVAI-------LAYFLLFS 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	76/240 (32%)
		CcmA	31..302	CDD:224054	96/314 (31%)
		ABC2_membrane	364..515	CDD:304374	34/144 (24%)
ABCG2	NP_181272.1	3a01204	95..754	CDD:273361	147/551 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920