Protein Alignment CG11069 and ABCG8

DIOPT Version :9

• Sequence 1: NP_651307.2
• Gene: CG11069 / 42976
• FlyBaseID: FBgn0039244
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_011531331.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 677
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 165/639 - (25%)
• Similarity: 279/639 - (43%)
• Gaps: 128/639 - (20%)

  Fly    35 LVLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGA--TRGQVLLNGSPLSKALFQQRCGY 97
            |.::.::..|.||:::||:||.|.|:.:|||||:.|..|.  ..||:.:||.|.|..|.::...:
Human    90 LGIQNLSFKVRSGQMLAIIGSSGCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQLVRKCVAH 154

  Fly    98 VTQSCTFVPGLTVAQTLHY-----TPTILSGYLKSSKVRQVLADLALSQVAHKRVEYLNI----- 152
            |.|....:|.|||.:||.:     .|...|...:..:|..|:|:|.|.|.|..||..:.:
Human   155 VRQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVGNMYVRGLSG 219

  Fly   153 SEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPF 217
            .|.||::||:||:.:|.:|:|||||.|||..:|:.|:..||..||.... :|:||.:||||:|..
Human   220 GERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRL-VLISLHQPRSDIFRL 283

  Fly   218 LDRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQIEA 282
            .|..|.:..|..:|.|..:.|::||..||:|||:..||..:|:.|:::|||||::.|.:.::.::
Human   284 FDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQELATREKAQS 348

  Fly   283 LVERFSR------------------ETPISDAPLNNMGSGKVPLAYGKPGELKVWVMLYLKLLAS 329
            |...|..                  |....::.:..:.:..:|.....||.::.:..|..:.:::
Human   349 LAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPLDTNCLPSPTKMPGAVQQFTTLIRRQISN 413

  Fly   330 TFSCGLVGMKTLFLRLLLLPLALSILWAFYTDVGDDSHGFFTKNGMILNILGLSYGCGILTTISL 394
            .|.    .:.||.:                       ||              :..|.:..||..
Human   414 DFR----DLPTLLI-----------------------HG--------------AEACLMSMTIGF 437

  Fly   395 FPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASC-----VVYPLLLDVKYNNGTVF 454
            .     .|...:.:..:..|..|:......|||:.:..||:.|     ::|..|.|..|..|..|
Human   438 L-----YFGHGSIQLSFMDTAALLFMIGALIPFNVILDVISKCYSERAMLYYELEDGLYTTGPYF 497

  Fly   455 ------------AYLLVALWSSFVLA------EQLTIAFLLVVKVPF--------NAAIAVTY-- 491
                        ||:::....::.||      :...:.||||..|.|        .||:..|:
Human   498 FAKILGELPEHCAYIIIYGMPTYWLANLRPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHM 562

  Fly   492 ------VLVISIALASGTVRSFKGL---QPWLQDNTKGTHTRYASSLLHSIAFQSRKLNCTPTAS 547
                  .|..|..||.|.:.:...|   ..|:   :|.:..|:....|..|.| ||:....|..:
Human   563 ASFFSNALYNSFYLAGGFMINLSSLWTVPAWI---SKVSFLRWCFEGLMKIQF-SRRTYKMPLGN 623

  Fly   548 VICPKPADFMHERLGLPDPDETIDVAASCAFAVGLAAFNMLVYLFPMPRCVRQK 601
            :......|.:...:.|    ::..:.|.....:||:...|::|...: |.::||
Human   624 LTIAVSGDKILSVMEL----DSYPLYAIYLIVIGLSGGFMVLYYVSL-RFIKQK 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	78/209 (37%)
		CcmA	31..302	CDD:224054	100/296 (34%)
		ABC2_membrane	364..515	CDD:304374	40/192 (21%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	78/209 (37%)
		3a01204	92..667	CDD:273361	161/630 (26%)
		ABC2_membrane	406..610	CDD:279410	47/252 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820