Protein Alignment CG11069 and ABCG4

DIOPT Version :9

• Sequence 1: NP_651307.2
• Gene: CG11069 / 42976
• FlyBaseID: FBgn0039244
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001135977.1
• Gene: ABCG4 / 64137
• HGNCID: 13884
• Length: 646
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 142/646 - (21%)
• Similarity: 262/646 - (40%)
• Gaps: 112/646 - (17%)

  Fly     7 DYVLEAHNIFH--------------TTEVDGGGCFNGAGNSALVLKGVNLTVHSGEVMAILGSKG 57
            :::.||....|              :..|..|.|:...|...| ||.::......|::.|:|..|
Human    42 NHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTL-LKCLSGKFCRRELIGIMGPSG 105

  Fly    58 SGKRALLDVISRRADGATRGQVLLNGSPLSKALFQQRCGYVTQSCTFVPGLTVAQTLHYTPTILS 122
            :||...:::::...:...:||:|:||.|.....|::...|:.|....:|.|||.:.:     ::|
Human   106 AGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAM-----MVS 165

  Fly   123 GYLKSSK--------VRQVLADLALSQVAHKRVEYLNISEARRLAIGIQLVRDPVMLLLDEPTHG 179
            ..||.|:        |.::|..|.|...:|.|...|:..:.:||||.::||.:|.::..||||.|
Human   166 ANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSG 230

  Fly   180 LDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFLDRALFLCLGGVVYSGGTRAMLEYFHG 244
            ||..|.:.::|::.:.| :.|..|:.::.:|.:.:|...|:...|..|..::.|....::.|..|
Human   231 LDSASCFQVVSLMKSLA-QGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKG 294

  Fly   245 IGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQ--IEALVERFS----RETPISDAPLNNMGS 303
            :|..||...||..:.:.:::.:....:..|..:.|  :.|:.|:.|    .|.|....|.
Human   295 LGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPC----- 354

  Fly   304 GKVPLAYGKPGELK-----------------VWVMLYLKLLASTFSCGLVGMKTLFLRLLLLPLA 351
                     |.|:.                 ::...:|.:|..|....|     .|:..:::.:.
Human   355 ---------PPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHL-----RFMSHVVIGVL 405

  Fly   352 LSILWAFYTDVGDDSHGFFTKNG-MILNILGLSYGCGILTTISLFPIWRKKFSQDTPEGLYSGTT 415
            :.:|   |..:|||:...|...| :..::|.|.: ..::.|:..||:....|.::.....||...
Human   406 IGLL---YLHIGDDASKVFNNTGCLFFSMLFLMF-AALMPTVLTFPLEMAVFMREHLNYWYSLKA 466

  Fly   416 LLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVFAYLLVALWSSFVLAEQLTIAFL-LVV 479
            ..:|.....:||..|..|:...:||       :..|.........|:|:...|..|....| |::
Human   467 YYLAKTMADVPFQVVCPVVYCSIVY-------WMTGQPAETSRFLLFSALATATALVAQSLGLLI 524

  Fly   480 KVPFNAAIAVTY---VLVISIALASGTVRSFKGLQPWLQDNTKGTHTRYA--SSLLHSIAFQSRK 539
            ....|:....|:   |..|.:.|.||...|||.:..:||.::..::.||.  ..:|.....:...
Human   525 GAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGD 589

  Fly   540 LNCTPTASVICPKPADFMHERLGLPDPD---ETIDVAAS------CAFAVGLAAFNMLVYL 591
            |.|              :.||....:|.   ..:||..:      ....:...|..:|.||
Human   590 LTC--------------LEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYL 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	62/239 (26%)
		CcmA	31..302	CDD:224054	74/284 (26%)
		ABC2_membrane	364..515	CDD:304374	36/155 (23%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	142/644 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810