DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11069 and CG5853

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	598	Identity:	132/598 - (22%)
Similarity:	221/598 - (36%)	Gaps:	149/598 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KGVNLTVHSG-------------------EVMAILGSKGSGKRALLDVISRRADGATRGQVLLNG 83
            |.::|||..|                   :::||:|..|:||..|||.:|........|.:||||
  Fly   108 KELSLTVKLGFNRGSKEILHNVCGKFPGSQLIAIMGPSGAGKSTLLDALSGFKTTGVDGSILLNG 172

  Fly    84 SPLSKALFQQRCGYVTQSCTFVPGLTVAQTLHYTPTILSGYL-----KSSKVRQVLADLALSQVA 143
            .......|::...|:||.....|.|||.:.:|....:..|..     |.|::..:|  |.|....
  Fly   173 RRRDLPSFRRMSCYITQDDRLQPLLTVNENMHIAADLKLGQTVSYEEKESRIEDIL--LLLGLYN 235

  Fly   144 HKRVEYLNIS--EARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLS 206
            |.:...:.:|  :.:||:|.::|:.:|.::.|||||.|||..|...::.:|.....: |..|:.:
  Fly   236 HDQTLTMRLSGGQKKRLSIAMELINNPTVMFLDEPTTGLDSSSCTKVLELLKKLTSQ-GRTIICT 299

  Fly   207 LEKPRSDVFPFLDRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYL---C------- 261
            :.:|.:.:|...|:...|..|..||.|.|:.::.:...:..|||...||..|.:   |
  Fly   300 IHQPTAKLFQIFDQVYVLSAGNCVYQGSTQKLVPFLQSVDLPCPMYHNPADYIIELACGEYGYDK 364

  Fly   262 -----LSTVDRRSRDRFLESSQ--QIEALVERF-----SRETPISDAPLNNMGSGKVPLAYGKPG 314
                 |:|.:......|...|.  :.|.|:.::     ::...:.|...:|..|  |.|..|...
  Fly   365 VDTLKLATENGSCLTWFHNPSAVLRAEVLMRKYPIPKKTKSRSLEDTSYSNQCS--VLLRRGFIK 427

  Fly   315 ELKVWVMLYLKLLASTFSCGLVGMKTLFLRLLLLPLALSILWAFYTDVGDDSHGFFTKNGMILNI 379
            ..:...|.:|::..:.....|.|                   |.|...|.:.........::..|
  Fly   428 AKRDTTMTHLRIGVNIAVAALFG-------------------AMYDHTGREGSRVLDNYNLLFAI 473

  Fly   380 LGLSYGCGILTTISLFP-----IWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVV 439
            |.......::.|:..||     :.::.|::     .||......|...|.:|.|.:|....:.:|
  Fly   474 LMHHSMTTMMLTVLTFPMDISILIKEHFNR-----WYSLKAYYTAMTLVDLPISIISCFFFTVIV 533

  Fly   440 Y-----PL------------LLDVKYNNGTVFA----YLLVALWSSFV----LAEQLTIAFLLVV 479
            |     |:            ||       |||.    .|::..|...|    ||..|||..::.
  Fly   534 YLWSYQPMEWIRFFMFFSISLL-------TVFVGHSFGLMIGAWFDVVNGTFLAPVLTIPMMMF- 590

  Fly   480 KVPFNAAIAVT------------YVLVISIALASGTVRSFKGLQPWLQDNTKGT---------HT 523
                 |...||            ::..:...| .|.:.:..||.       :||         |.
  Fly   591 -----AGFGVTLRDLPSYLRWGSHISYLRYGL-EGFISAIYGLD-------RGTLACEEAPYCHY 642

  Fly   524 RYASSLLHSIAFQ 536
            ||....|..|..:
  Fly   643 RYPKKFLEEITMR 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	61/220 (28%)
		CcmA	31..302	CDD:224054	78/311 (25%)
		ABC2_membrane	364..515	CDD:304374	36/192 (19%)
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	132/598 (22%)
		ABCG_EPDR	102..326	CDD:213180	61/220 (28%)
		ABC2_membrane	420..623	CDD:279410	43/240 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920