DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and Abca6

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_006247716.1	Gene:	Abca6 / 303639	RGDID:	1308998	Length:	1630	Species:	Rattus norvegicus

Alignment Length:	643	Identity:	139/643 - (21%)
Similarity:	233/643 - (36%)	Gaps:	180/643 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 FNGAGNSALVLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGATRGQVLLNGSPLSKAL- 90
            :.|.......|||:...|:..::.|:||..|:||.:||:::: .....|.|...:....||:..
  Rat   491 YKGKSGKVEALKGLFFDVYESQITAVLGHGGAGKSSLLNILN-GLSVPTSGLATVYNKNLSEMQD 554

  Fly    91 ---FQQRCGYVTQSCTFVPGLTVAQTLHYTPTILSGYLKSS---KVRQVLADLALSQVAHKRVEY 149
               .::..|...|.......|||.:.|.....| .|.:..|   :|:|:|::|.:..:..:..|:
  Rat   555 LKEIRKMIGVCPQHNVQFDALTVKENLTLFANI-KGIVPQSVAQEVQQILSELDMQTIQDELAEH 618

  Fly   150 LNISEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLE-KPRSD 213
            |:..:.|:|..|:.::.||.:|||||||.||||.|...:...|..  ::....||.|.: ...:|
  Rat   619 LSEGQKRKLTFGVAILGDPRILLLDEPTAGLDPFSRQRVWGFLKE--RRADRVILFSTQFTDEAD 681

  Fly   214 VFPFLDRALFLCLGGVVYSGGTRAMLEYFHGIGF-----------------------PCPQL--- 252
            :  ..||.:.|. .|.:...|:...|:...|:|:                       |..:|
  Rat   682 I--LADRKVILS-NGALKCTGSSVFLKRKWGLGYHLSLFMNETCDSEQLTSFINHHIPGAKLKAK 743

  Fly   253 -ENPLMYYLCL----------STVDRRSRDRFLESSQQIEALVERFSR--------------ETP 292
             :..|:|.|.|          |.:|:.|....:.....:..|.|.|..              ||.
  Rat   744 TKEKLVYTLPLEKTSKFPEFFSDLDKYSGQGLMNYEVSMSTLNEVFMNLEGEPSTTQDFEKGETL 808

  Fly   293 ISDAPLNNMGSGKVPLAYGKP--GELKVWVMLYLKLLASTFSCGLVGMKTLFLR------LLLLP 349
            .....||.|......|:..:.  ..:.:|.|..         |.:..::.|.||      |..||
  Rat   809 TDSDSLNEMEVAPPSLSKAQKTMSAMSLWRMQV---------CAIARLRVLKLRRERKAFLTFLP 864

  Fly   350 -LALSIL-----------------WAFYTDV-----GDDSHGFFTKNGMILN--------ILGLS 383
             |.:|::                 |.|.||:     |....|..|...:|.|        :..|.
  Rat   865 LLGISLIPLITEYMANALIEVKTNWEFKTDLYFLSPGQLPQGLRTSLLVINNTESNIEDFVQSLK 929

  Fly   384 YGCGILTTISLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAV-SAVIASCVVYPLLLDVK 447
            :. .|:..:..|.      :::..|.|.....::::.......|||| :.....|  :|:|::|
  Rat   930 HQ-NIVLEVDDFE------NRNATESLSYNGAIIVSGRQKDYRFSAVCNTKRLHC--FPILMNV- 984

  Fly   448 YNNG---------------TVFAYLLVALWSSFVLAEQLTIAFLLVVKVPFNAAIAVTYVLVISI 497
            .:||               .|.:..:|.:|.. :|...|:|.|:               |..:|.
  Rat   985 ISNGILRMLNHTQHIRLEEDVLSSGIVVVWFG-ILEASLSILFI---------------VCSVSP 1033

  Fly   498 ALASGTVRSFK----------GLQP---W----LQDNT-------KGTHTRYASSLLH 531
            .:|..::..||          ||.|   |    |.|.|       .|..|.|.:.|:|
  Rat  1034 HIAMSSISDFKKKADSQLWISGLYPSAYWCGQALVDITLLSGILLTGYITLYTTKLMH 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	58/213 (27%)
		CcmA	31..302	CDD:224054	77/329 (23%)
		ABC2_membrane	364..515	CDD:304374	35/191 (18%)
Abca6	XP_006247716.1	ABC2_membrane_3	35..420	CDD:289468
		ABC2_membrane_4	220..409	CDD:289500
		CcmA	480..795	CDD:224054	74/310 (24%)
		ABC_subfamily_A	482..705	CDD:213230	59/220 (27%)
		ABC2_membrane_3	859..1171	CDD:289468	53/259 (20%)
		ABC2_membrane_4	1007..1178	CDD:289500	23/101 (23%)
		CcmA	1279..1605	CDD:224054
		ABC_subfamily_A	1300..1514	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000