DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and Abca12

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_237242.6	Gene:	Abca12 / 301482	RGDID:	1304586	Length:	2595	Species:	Rattus norvegicus

Alignment Length:	502	Identity:	118/502 - (23%)
Similarity:	196/502 - (39%)	Gaps:	120/502 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SALVLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGATRGQVLLNGSPLSKAL--FQQRC 95
            |...:..:||..:.|.:.::||..|:||...:.::: ...|||.|.:.:.|..:...|  .::..
  Rat  1357 SKTAVDNLNLNFYEGHITSLLGPNGAGKTTTISMLT-GLFGATAGTIFVYGKDIKTDLNTVRKNM 1420

  Fly    96 GYVTQSCTFVPGLTVAQTLHYTPTILSGYLK---------SSKVRQVLADLALSQVAHKRVEYLN 151
            |...|.......||..:.|     :|.|.:|         ..:|::.|.|..|....||||..|:
  Rat  1421 GVCMQHDVLFSYLTTKEHL-----LLYGSIKVPHWTKKQLHEEVKRTLKDTGLYSHRHKRVGTLS 1480

  Fly   152 ISEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLS---LEKPR-- 211
            ....|:|:|.|.|:....:::||||:.|:||.|...:..::|.  .||...|:||   |::..
  Rat  1481 GGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRRSIWDVISK--NKTARTIILSTHHLDEAEVL 1543

  Fly   212 SDVFPFLDRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLS-----TVDRRSRD 271
            ||...||::....|.|...|       |:...|.|           |:|.|:     .:|..:..
  Rat  1544 SDRIAFLEQGGLRCCGSPFY-------LKEAFGDG-----------YHLTLTKKKSPNLDTNAIC 1590

  Fly   272 RFLESSQQIEA-LVERFSRE--------------TPISDAPLN-----NMGSGKVPL-AYGKPGE 315
            ..:..:..|:: |.|.:.:|              |.:|.|.|:     :.|.||:.: .||....
  Rat  1591 DTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDT 1655

  Fly   316 LKVWVMLYLKLLASTFSCGLVGMKTLFLRLLLLPLA--------LSILWAFYTDVGD-------- 364
            ....|  :|.|...:..||.:.::.|..|.:..|.|        ||:..:.:||..|
  Rat  1656 TVEEV--FLNLTKDSQKCGNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSER 1718

  Fly   365 -DSHGFFTKNGMILNILGLSYGCGILTTISLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFS 428
             |..|...|.  |:.||           |..|...|:.:     :||.:...|.|.:.:.::
  Rat  1719 LDGFGLLLKK--IMAIL-----------IKRFHHTRRNW-----KGLIAQVVLPIVFVATAM--- 1762

  Fly   429 AVSAVIASCVVYPLLL--DVKYNNGTVFAY----------LLVALWS 463
            .:..:..|...||.||  ...|.|....|:          |:.|||:
  Rat  1763 GLGTLRDSSNSYPELLISPSIYGNSEQTAFYANFDPSTNALVSALWN 1809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	59/215 (27%)
		CcmA	31..302	CDD:224054	74/309 (24%)
		ABC2_membrane	364..515	CDD:304374	26/121 (21%)
Abca12	XP_237242.6	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	60/227 (26%)
		ABC_subfamily_A	1350..1565	CDD:213230	59/222 (27%)
		ABC2_membrane_3	<1913..2174	CDD:289468
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000