DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and wht-6

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_498425.2	Gene:	wht-6 / 188911	WormBaseID:	WBGene00007060	Length:	613	Species:	Caenorhabditis elegans

Alignment Length:	519	Identity:	133/519 - (25%)
Similarity:	228/519 - (43%)	Gaps:	72/519 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LVLKGVNLTVHSGEVMAILGSKGSGKRALLDVI-SRRADG-ATRGQVLLNGSPLSKALFQQRCGY 97
            |:||.|:....|||::|::|:.|:||..||::: .|...| :|.|.:.:||:.::..: ....|:
Worm    49 LLLKNVSGYAKSGELLALMGASGAGKTTLLNMLMCRNLKGLSTEGTITVNGNEMAHKI-SSISGF 112

  Fly    98 VTQSCTFVPGLTVAQTLHYTPTIL---SGYLKSSKVRQVLADLALSQVAHKRV----EYLNIS-- 153
            ..|...||..|||.:.|.....:.   |..|:..:|..||..|.|.:....::    |...||
Worm   113 AQQEELFVGTLTVKEYLMIQAKLRINGSKKLREDRVTDVLHQLKLWKCRDSKIGVIGEKKGISGG 177

  Fly   154 EARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFL 218
            |||||....:::.:|.:|..||||.|||...|..:|.||...| |||..|:.::.:|.|.::...
Worm   178 EARRLTFACEMLSNPSLLFADEPTTGLDSFMAESVIQILKGIA-KTGRTIICTIHQPSSQLYQMF 241

  Fly   219 DRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENP---LMYYLCLST-VDRRSRDRFLESSQQ 279
            .|.::|..|...:.|..:..:.:|...|...|...||   ::|.|.:.. .:::|.||
Worm   242 HRVIYLANGSTAFQGTPQESISFFEKCGHRVPDEYNPSEWIIYKLAVQPGQEKQSNDR------- 299

  Fly   280 IEALVERFSRE-------TPISDAPLNNMGSGKVPLAYGKPGELKVWVMLYLKLLASTFSCGLVG 337
            |:.:||::...       ..:||.      |.|:|     |.|:. ...::.::.|.:..||:..
Worm   300 IQKIVEQYEDSDHQKRVMEQLSDV------SEKIP-----PPEMH-RANVFTQIFALSTRCGIDV 352

  Fly   338 MKTLFLRL------LLLPLALSILWAFYTDVGDDSHGFFTKNGMILNILG---LSYGCGILTTI- 392
            .:...|.|      :|..|.:.:|   |.....|:.|....||.:..:.|   .|....|:..:
Worm   353 WRAPQLTLAKVIQKILFGLFIGLL---YLRTPYDARGIHNINGALFFLAGEYIYSTAYAIMFFLN 414

  Fly   393 SLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVFAYL 457
            :.||:..:::.    :|||:..|...|.....||..:...:|...:||.|:    ..|.:|...:
Worm   415 NEFPLVAREYH----DGLYNLWTYYFARCISLIPLFSTDGLILLFIVYWLI----GLNTSVMQVI 471

  Fly   458 LVALWSSFVLAEQLTIAFLLVVKVPF----NAAIAVTYVLVISIALAS--GTVRSFKGLQPWLQ 515
            :.::.:  |||.|...||.:.:...|    ..|:..:..||:......  |...:|.....|||
Worm   472 VASIIT--VLASQAASAFGIAMSCIFPTAQMTAVMASPPLVLFRLFGGLYGNTNTFPAAIRWLQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	66/208 (32%)
		CcmA	31..302	CDD:224054	82/288 (28%)
		ABC2_membrane	364..515	CDD:304374	35/160 (22%)
wht-6	NP_498425.2	P-loop_NTPase	<3..>81	CDD:393306	14/31 (45%)
wht-6	NP_498425.2	3a01204	50..613	CDD:273361	132/518 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3467
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770