DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and abch-1

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_495320.1	Gene:	abch-1 / 174078	WormBaseID:	WBGene00016973	Length:	595	Species:	Caenorhabditis elegans

Alignment Length:	576	Identity:	164/576 - (28%)
Similarity:	257/576 - (44%)	Gaps:	85/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YVLEAHNIFHTTEVDGGGCFNGAGNSALV---LKGVNLTVHSGEVMAILGSKGSGKRALLDVISR 69
            :|||..:|...|.:..|..|:.......|   ||.::.|..|||:.||:|...|||..||:.::.
Worm     5 HVLECKSISFMTAISNGTWFSKIYKPPSVFQILKNISFTATSGEIHAIVGVADSGKTTLLEALTS 69

  Fly    70 RADGATRGQVLLNGSPLSKALFQQRCGYVTQSCTFVPGLTVAQTLHYTPTI-LSGYLKSSKVRQV 133
            .|.|...|..:|:...|::..|.:.|.::.....:...|:|...|:|...: ||....|.::...
Worm    70 GAGGDIGGIAMLDKFMLTRRRFNKFCSHINYRNQYPSSLSVRSLLYYHARLCLSSTHTSLEIDHR 134

  Fly   134 LADL-ALSQV---AHKRVEYLNISEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSN 194
            :::| |:..|   ||.::|.|:.|..||:...::|::||::.::|:||..|.|||||.||..|..
Worm   135 ISELSAMFDVIGYAHDKLEDLSFSARRRVMTVMELLKDPILTIIDDPTAYLSPLSAYQLIYALHF 199

  Fly   195 TAKKTGCGILLSLEKPRSDVFPFLDRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYY 259
            .|.|....|:::|...|||:...|..|..|..|.|.|||..|.:..:|...||.||..|||..||
Worm   200 YAAKFNRIIIITLRNVRSDLSHLLGSATCLFYGEVAYSGQMRLLPNHFKKAGFECPPNENPAAYY 264

  Fly   260 LCLSTVDRRSRDRFLESSQQIEALVE-RFSRETPISDAPLNNMGSGKVPLAYGK--PGELKVWVM 321
            |.|.|:|:.|..:.:|:.::...||. |...:|....:..:..|:| |.|..|:  |....|..:
Worm   265 LSLLTIDKESMQKVMETQEKATKLVAFRTDNDTSSDISGSSATGTG-VLLDSGRKNPSISTVAAI 328

  Fly   322 LY---LKLLASTFSCGLVGMKTLFLRLLLLPLALSILWAFYTDVGDDSHGFFTKNGMILNILGLS 383
            |:   |.|:.||.|..|.|       |:..|:..::| :|.......|..||.|   :|..|.|
Worm   329 LFRRVLSLIGSTPSNSLAG-------LIAFPVTAAVL-SFLRPTSLPSSLFFWK---LLTFLYL- 381

  Fly   384 YGCGILTTISLFPIWRKKFSQDTPE-GLYSGTTLLIAYNSVSIPFSAV-SAVIASCVVYP----- 441
                :|.||.:||.:.|.......| .||..||.|..::...:.:|.: |::....|::.
Worm   382 ----LLQTIVIFPNYSKTSLLSFRECNLYCQTTSLTIFSIFFLVYSCIQSSLFVGIVLWSFKSEA 442

  Fly   442 ---------LLLDVKYNNGTVFA-YL-----LVALWSSFVLA------------EQLTIAFLLVV 479
                     ||....::..|:.| ||     :|.|.:..:||            ...:|.:.:.|
Worm   443 MFQISLNLFLLSIFSFSIFTICARYLKNCSNIVILQTIIILAFFVSGNGVTGTTTSSSIQYYIGV 507

  Fly   480 KVPFNAAIAVTYVLVISIALASGTVRSFKGLQPWLQDNTKGTHTRYASSL---LHS 532
            ..|||      |...:...|.|.::           ||.:.|...|...|   |||
Worm   508 INPFN------YSNFLLSKLLSSSI-----------DNEECTFPSYMCKLSMNLHS 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	71/225 (32%)
		CcmA	31..302	CDD:224054	90/279 (32%)
		ABC2_membrane	364..515	CDD:304374	40/184 (22%)
abch-1	NP_495320.1	P-loop_NTPase	18..238	CDD:393306	69/219 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165238
Domainoid	1	1.000	85	1.000	Domainoid score	I5247
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I2942
Isobase	1	0.950	-	0	Normalized mean entropy	S3467
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007488
OrthoInspector	1	1.000	-	-		oto18164
orthoMCL	1	0.900	-	-		OOG6_109019
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2367
SonicParanoid	1	1.000	-	-		X10207
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.730