DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and Abcg5

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	598	Identity:	176/598 - (29%)
Similarity:	293/598 - (48%)	Gaps:	65/598 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VLKGVNLTVHSGEVMAILGSKGSGKRALLDVIS--RRADGATRGQVLLNGSPLSKALFQQRCGYV 98
            :||.|:|.:.||:.|.||||.||||..|||.||  .|..|...|:|.:||..|.:..||....|:
  Rat    69 ILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYL 133

  Fly    99 TQSCTFVPGLTVAQTLHYTPTILSGYLKSS-------KVRQVLADLALSQVAHKRVEYLNI---- 152
            .||..|:..|||.:||.||..:.   |:||       ||..||.:|:||.||.:.:...|.
  Rat   134 LQSDVFLSSLTVRETLRYTAMLA---LRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFGGIS 195

  Fly   153 -SEARRLAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFP 216
             .|.||::|..||::||.:::|||||.|||.::|..::.:|...|::... :::::.:|||::|.
  Rat   196 SGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRI-VIVTIHQPRSELFH 259

  Fly   217 FLDRALFLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQIE 281
            ..|:...|..|.:|:.|....||.:|:..|:|||:..||..:|:.|::||.:||:|.:|:.::::
  Rat   260 HFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQ 324

  Fly   282 ALVERFSRETPISDAPLNNMGSGK----VPLAYGK----PGELKVWVMLYLKL--LASTFSCGLV 336
            .|...| |::.|....|.|:...:    :|:...|    ||       ::.||  |....:..|:
  Rat   325 MLESAF-RQSDICHKILENIERTRHLKTLPMVPFKTKNPPG-------MFCKLGVLLRRVTRNLM 381

  Fly   337 GMKTLFLRLLLLPLALSILWAFYT----------DVGDDSHGFFTKNGMILNILGLSYGCGILTT 391
            ..|.:.:..|:..|.:.:...||.          .|.|       :.|::..::|.:...|:|..
  Rat   382 RNKQVVIMRLVQNLIMGLFLIFYLLRVQNNMLKGAVQD-------RVGLLYQLVGATPYTGMLNA 439

  Fly   392 ISLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVFAY 456
            ::|||:.|....|::.:|||....:|:||...::|||.|:.||.|.|.|..|  ..|.....|.|
  Rat   440 VNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTL--GLYPEVARFGY 502

  Fly   457 LLVALWSSFVLAEQLTIAFLLVVKVPFNAAIAVTYVLVIS-IALASGTVRSFKGLQPWLQDNTKG 520
            ...||.:..::.|.||:..|.:|:.| |...::..:|.|| :.:.||.:|:.:.:...|:.....
  Rat   503 FSAALLAPHLIGEFLTLVLLGMVQNP-NIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYF 566

  Fly   521 THTRYASSLLHSIAFQSRKLNCTPTASVICPKPADFMHERLGLPDPDETIDVAASCAFAVGLAAF 585
            |..:|...:|....|......|..:.:.:...|...|.:.:..        :..:|..|......
  Rat   567 TFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQF--------IEKTCPGATSRFTT 623

  Fly   586 NMLVYLFPMPRCV 598
            |.|:....:|..|
  Rat   624 NFLILYSFIPTLV 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	80/210 (38%)
		CcmA	31..302	CDD:224054	104/279 (37%)
		ABC2_membrane	364..515	CDD:304374	44/151 (29%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		ABCG_White	50..276	CDD:213201	80/210 (38%)
		3a01204	61..646	CDD:273361	176/598 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350998
Domainoid	1	1.000	103	1.000	Domainoid score	I6646
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31909
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47256
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0007488
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109019
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.720