DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11069 and Abcg1

DIOPT Version :9

Sequence 1:	NP_651307.2	Gene:	CG11069 / 42976	FlyBaseID:	FBgn0039244	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_033723.1	Gene:	Abcg1 / 11307	MGIID:	107704	Length:	666	Species:	Mus musculus

Alignment Length:	579	Identity:	133/579 - (22%)
Similarity:	240/579 - (41%)	Gaps:	95/579 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VLKGVNLTVHSGEVMAILGSKGSGKRALLDVISRRADGATRGQVLLNGSPLSKALFQQRCGYVTQ 100
            :|||::...:|||::||:|..|:||..|:::::...:...:|.||:||.|.....|::...|:.|
Mouse   100 LLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSCYIMQ 164

  Fly   101 SCTFVPGLTVAQTLHYTPTILSGYLKSSK--------VRQVLADLALSQVAHKRVEYLNISEARR 157
            ....:|.|||.:.:     ::|.:||..:        |:::|..|.|...|:.|...|:..:.:|
Mouse   165 DDMLLPHLTVQEAM-----MVSAHLKLQEKDEGRREMVKEILTALGLLPCANTRTGSLSGGQRKR 224

  Fly   158 LAIGIQLVRDPVMLLLDEPTHGLDPLSAYLLISILSNTAKKTGCGILLSLEKPRSDVFPFLDRAL 222
            |||.::||.:|.::..||||.|||..|.:.::|::...| :.|..|:.::.:|.:.:|...|:..
Mouse   225 LAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLA-QGGRSIVCTIHQPSAKLFELFDQLY 288

  Fly   223 FLCLGGVVYSGGTRAMLEYFHGIGFPCPQLENPLMYYLCLSTVDRRSRDRFLESSQQIEALVE-- 285
            .|..|..||.|....::.|...:|..||...||..:.:.:::.:...     ::|:.:.|:.|
Mouse   289 VLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGD-----QNSRLVRAVREGM 348

  Fly   286 ---RFSRETPISDAPLNNMGSGKVPLAYGKPGELKVWVMLYLKLLASTFSCG------LVGMKTL 341
               .:.|:.. .|..:|       |..:.:|.|         :..||...|.      |.....|
Mouse   349 CDADYKRDLG-GDTDVN-------PFLWHRPAE---------EDSASMEGCHSFSASCLTQFCIL 396

  Fly   342 FLRLLLLPLALSIL---------------WAFYTDVGDDSHGFFTKNG-MILNILGLSYGCGILT 390
            |.|..|..:..|:|               ...|..:|:::....:.:| :..::|.|.: ..::.
Mouse   397 FKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMF-AALMP 460

  Fly   391 TISLFPIWRKKFSQDTPEGLYSGTTLLIAYNSVSIPFSAVSAVIASCVVYPLLLDVKYNNGTVFA 455
            |:..||:....|.::.....||.....:|.....:||..:..|....:||.:   ....:..|..
Mouse   461 TVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWM---TSQPSDAVRF 522

  Fly   456 YLLVALWSSFVLAEQLTIAFLLVVKVPFNAAIAVTYVLVISIALASGTVRSFKGLQPWLQDNTKG 520
            .|..||.:...|..|.....:.........|..|..|..|.:.|.||...||..:..:||..:..
Mouse   523 VLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMSYI 587

  Fly   521 THTRYA-SSLLHSIAFQSRKLNCTPTASVICPKPADFMHERLGLPDPDETIDVAASCAF 578
            ::.||. ..::.||                           .||...|...|:|.:|.|
Mouse   588 SYVRYGFEGVILSI---------------------------YGLDREDLHCDIAETCHF 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11069	NP_651307.2	ABCG_White	15..233	CDD:213201	62/204 (30%)
		CcmA	31..302	CDD:224054	75/278 (27%)
		ABC2_membrane	364..515	CDD:304374	30/151 (20%)
Abcg1	NP_033723.1	3a01204	60..666	CDD:273361	133/579 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820