DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31121 and ABCG2

DIOPT Version :9

Sequence 1:	NP_733058.1	Gene:	CG31121 / 42975	FlyBaseID:	FBgn0051121	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001335914.1	Gene:	ABCG2 / 9429	HGNCID:	74	Length:	655	Species:	Homo sapiens

Alignment Length:	713	Identity:	154/713 - (21%)
Similarity:	272/713 - (38%)	Gaps:	176/713 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 GNGNGHNPGSRKQ------SGMGLIYPNIQVHCLDVN------PCLRGVSMQ--------AKAGD 330
            ||.||. |.:...      .|..|.:.||   |..|.      ||.:.|..:        .|.|
Human    15 GNTNGF-PATASNDLKAFTEGAVLSFHNI---CYRVKLKSGFLPCRKPVEKEILSNINGIMKPG- 74

  Fly   331 LFAIMATSQREGSALAECLAGLTE--RLGGEILINGQQVSRRGLRELCSYVPALEVSSLDPRMSV 393
            |.||:..:....|:|.:.||...:  .|.|::||||   :.|.....|:....::...:...::|
Human    75 LNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLING---APRPANFKCNSGYVVQDDVVMGTLTV 136

  Fly   394 QCTLNFHAALR--GPIDRSDLEERMDVLIEDLGLNTVRASNVST-----LTHSEKQRLSVACQLL 451
            :..|.|.||||  ..:...:..||::.:|::|||:.|..|.|.|     ::..|::|.|:..:|:
Human   137 RENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELI 201

  Fly   452 AQSSLLILDQVTSNMDIFDTFFLVEYLRQWCSGGRIVIMTLQPPTFEILSMCSGVLLLSGGRTVF 516
            ...|:|.||:.|:.:|......::..|::....||.:|.::..|.:.|..:...:.||:.||.:|
Human   202 TDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMF 266

  Fly   517 SGSRADLPRHMGELGYPCPPFKNPADYYLDLVTLD----------DLSAAAMLESSAR----IES 567
            .|...:...:....||.|..:.||||::||::..|          |..|..::|.|.:    ||.
Human   267 HGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEK 331

  Fly   568 LANAWDQINSEPPLAAPPASLPNFTMKAGFFGQISALIKRFAGYKQPGSL--------------- 617
            ||..:  :||                  .|:.:..|.:.:.:|.::...:
Human   332 LAEIY--VNS------------------SFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQ 376

  Fly   618 LTWISK----------------LIAAAVLSLFIGCIFWDVPASDPQLSYHDRLGYHHCVMVLVYW 666
            |.|:||                :|...||.|.||.|::.:.        :|..|..:...||.:.
Human   377 LRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLK--------NDSTGIQNRAGVLFFL 433

  Fly   667 PLVMLTIRDTQEDRRHAERDIRLGLYTRSLYIIVQSLLGLFPSLCIWLAYLLPAHSMAG-LYTYS 730
            .........:..:....|:.:.:..|....|.:....||..      |:.|||...:.. ::|..
Human   434 TTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKL------LSDLLPMRMLPSIIFTCI 492

  Fly   731 NSSDTGIYLYMG-------YMLLYLTLIQTLALFCAHLLPCKVSASIVNGLISLAVAAV------ 782
                  :|..:|       :.::..||:  :..:.|..:...::|.  ..::|:|...:
Human   493 ------VYFMLGLKPKADAFFVMMFTLM--MVAYSASSMALAIAAG--QSVVSVATLLMTICFVF 547

  Fly   783 ----GGYLVHPQNLAQFWSWLQFVSPERWLLPVLVQDEYSAETLSNSAGLQLCRNKQVQHQEIIV 843
                .|.||:...:|.:.||||:.|..|:....|                        ||.|.:.
Human   548 MMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTAL------------------------QHNEFLG 588

  Fly   844 QQPCPPPNGT-------QVLVDFELLPQQHV-LDPTPTYDQTTSVALVLGSVLVFCVTFIVFL 898
            |..||..|.|       ......|.|.:|.: |.|...:....::|.::...|......::||
Human   589 QNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31121	NP_733058.1	P-loop_NTPase	319..518	CDD:304359	56/215 (26%)
		cbiO	319..491	CDD:130234	49/188 (26%)
		ABC2_membrane	621..809	CDD:279410	41/221 (19%)
ABCG2	NP_001335914.1	3a01204	55..649	CDD:273361	140/665 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750