Protein Alignment CG31121 and ABCG8

DIOPT Version :9

• Sequence 1: NP_733058.1
• Gene: CG31121 / 42975
• FlyBaseID: FBgn0051121
• Length: 911
• Species: Drosophila melanogaster
• Sequence 2: XP_011531331.1
• Gene: ABCG8 / 64241
• HGNCID: 13887
• Length: 677
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 162/631 - (25%)
• Similarity: 286/631 - (45%)
• Gaps: 98/631 - (15%)

  Fly   316 NPC---LRGVSMQAKAGDLFAIMATSQREGSALAECLAGLTER------LGGEILINGQQVSRRG 371
            |.|   ::.:|.:.::|.:.||:.:|   |...|..|..:|.|      ..|:|.||||..|.:.
Human    86 NSCELGIQNLSFKVRSGQMLAIIGSS---GCGRASLLDVITGRGHGGKIKSGQIWINGQPSSPQL 147

  Fly   372 LRELCSYVPALEVSSLDPRMSVQCTLNFHAALRGP--IDRSDLEERMDVLIEDLGLN---TVRAS 431
            :|:..::|  .:.:.|.|.::|:.||.|.|.:|.|  ..::..::|::.:|.:|.|.   ..|..
Human   148 VRKCVAHV--RQHNQLLPNLTVRETLAFIAQMRLPRTFSQAQRDKRVEDVIAELRLRQCADTRVG 210

  Fly   432 N--VSTLTHSEKQRLSVACQLLAQSSLLILDQVTSNMDIFDTFFLVEYLRQWCSGGRIVIMTLQP 494
            |  |..|:..|::|:|:..|||....:||||:.||.:|.|....||:.|.:...|.|:|:::|..
Human   211 NMYVRGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLAKGNRLVLISLHQ 275

  Fly   495 PTFEILSMCSGVLLLSGGRTVFSGSRADLPRHMGELGYPCPPFKNPADYYLDLVTLDDLSAAAML 559
            |..:|..:...|||::.|..::.|:...:.::...:|||||.:.||||:|:||.::|..|....|
Human   276 PRSDIFRLFDLVLLMTSGTPIYLGAAQHMVQYFTAIGYPCPRYSNPADFYVDLTSIDRRSREQEL 340

  Fly   560 ESSARIESLANAW-------DQI----------------NSEPPLAAPPASLPNFTMKAGFFGQI 601
            .:..:.:|||..:       |..                :|..||  ....||:.|...|...|.
Human   341 ATREKAQSLAALFLEKVRDLDDFLWKAETKDLDEDTCVESSVTPL--DTNCLPSPTKMPGAVQQF 403

  Fly   602 SALIKRFAG--YKQPGSLLTWISKLIAAAVLSLFIGCIFWDVPASDPQLSYHDRLGYHHCVMVLV 664
            :.||:|...  ::...:||...::   |.::|:.||.:::.  ....|||:.|.......:..|:
Human   404 TTLIRRQISNDFRDLPTLLIHGAE---ACLMSMTIGFLYFG--HGSIQLSFMDTAALLFMIGALI 463

  Fly   665 YWPLVMLTIRDTQEDRRHAERDIRLGLYTRSLYIIVQSLLGLFPSLCIW-LAYLLPAHSMAGLYT 728
            .:.:::..|.....:|.....::..||||...|...: :||..|..|.: :.|.:|.:.:|.|
Human   464 PFNVILDVISKCYSERAMLYYELEDGLYTTGPYFFAK-ILGELPEHCAYIIIYGMPTYWLANL-- 525

  Fly   729 YSNSSDTGIYLYMGYMLLYLTLI---QTLALFCAHLLPCKVSASIVNGLISLAVAAVGGYLVHPQ 790
                 ..|:..::.:.||...::   :.:||..|.|||....||..:..:..:....||:::
Human   526 -----RPGLQPFLLHFLLVWLVVFCCRIMALAAAALLPTFHMASFFSNALYNSFYLAGGFMI--- 582

  Fly   791 NLAQFW---SWLQFVSPERWLLPVLVQDEYSAETLSNSAGLQLCRNKQVQHQEIIVQQPCPPPNG 852
            ||:..|   :|:..||..||....|::.::|..|.....|          :..|.|       :|
Human   583 NLSSLWTVPAWISKVSFLRWCFEGLMKIQFSRRTYKMPLG----------NLTIAV-------SG 630

  Fly   853 TQVLVDFELLPQQHVLDPTPTYDQTTSVALVLGSVLVFCVTFIVFL 898
            .::|...|       ||..|.|   ....:|:|....|.|.:.|.|
Human   631 DKILSVME-------LDSYPLY---AIYLIVIGLSGGFMVLYYVSL 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31121	NP_733058.1	P-loop_NTPase	319..518	CDD:304359	63/211 (30%)
		cbiO	319..491	CDD:130234	56/184 (30%)
		ABC2_membrane	621..809	CDD:279410	45/194 (23%)
ABCG8	XP_011531331.1	ABCG_White	64..299	CDD:213201	65/217 (30%)
		3a01204	92..667	CDD:273361	160/625 (26%)
		ABC2_membrane	406..610	CDD:279410	51/219 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750