DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31121 and ABCG4

DIOPT Version :9

Sequence 1:	NP_733058.1	Gene:	CG31121 / 42975	FlyBaseID:	FBgn0051121	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001135977.1	Gene:	ABCG4 / 64137	HGNCID:	13884	Length:	646	Species:	Homo sapiens

Alignment Length:	666	Identity:	133/666 - (19%)
Similarity:	256/666 - (38%)	Gaps:	110/666 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 SESDFRAIGGMPHSRPESRAQIGGGGVPMAALRQANSRASIAVGQHHHQMQQH--QQQYGKHYGH 246
            :|....|:|          ..:|.|.|.||...:..:...: :..|..:::.|  :.|...|...
Human     2 AEKALEAVG----------CGLGPGAVAMAVTLEDGAEPPV-LTTHLKKVENHITEAQRFSHLPK 55

  Fly   247 RSHSEADLLGAGLSQVDGGGGGMGYDYNEARLYGSSRQYGNGNGHNPGSRKQSGMGLIYPNIQVH 311
            ||..:.:.:....|..:|                            |..||:....|:      .
Human    56 RSAVDIEFVELSYSVREG----------------------------PCWRKRGYKTLL------K 86

  Fly   312 CLDVNPCLRGVSMQAKAGDLFAIMATSQREGSALAECLAGLTER-LGGEILINGQQVSRRGLREL 375
            ||....|.|         :|..||..|....|.....|||..|. :.|:||:||:....|..|::
Human    87 CLSGKFCRR---------ELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKM 142

  Fly   376 CSYVPALEVSSLDPRMSVQCTLNFHAALRGPIDRSDLEERMDV-------LIEDLGLNTVRASNV 433
            ..|:  ::...|.|.::|...:...|.|:       |.|:.:|       ::..|||.:...:..
Human   143 SCYI--MQDDMLLPHLTVLEAMMVSANLK-------LSEKQEVKKELVTEILTALGLMSCSHTRT 198

  Fly   434 STLTHSEKQRLSVACQLLAQSSLLILDQVTSNMDIFDTFFLVEYLRQWCSGGRIVIMTLQPPTFE 498
            :.|:..:::||::|.:|:....::..|:.||.:|....|.:|..::....|||.:|.|:..|:.:
Human   199 ALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAK 263

  Fly   499 ILSMCSGVLLLSGGRTVFSGSRADLPRHMGELGYPCPPFKNPADYYLDLVT--LDDLS------- 554
            :..|...:.:||.|:.:|.|...:|..::..||..||.:.||||:.:::.:  ..||:
Human   264 LFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAV 328

  Fly   555 ---AAAMLESSARIESLANAWDQINSEPPLAAPPA-----SLPNFTMKAGFFGQISALIKRFAGY 611
               ..||.|..:..|         .:|.|...||.     .:.:.|.......|...|.||....
Human   329 QNGLCAMAEKKSSPE---------KNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLS 384

  Fly   612 KQPGSLLTWISKLIAAAVLSLFIGCIFWDVPASDPQLSYHDRLGYHHCVMVLVYWPLVMLTIRDT 676
            ....::||.: :.::..|:.:.||.::..:  .|......:..|.....|:.:.:..:|.|:...
Human   385 ILRDTVLTHL-RFMSHVVIGVLIGLLYLHI--GDDASKVFNNTGCLFFSMLFLMFAALMPTVLTF 446

  Fly   677 QEDRRHAERDIRLGLYTRSLYIIVQSLLGL-FPSLCIWLAYLLPAHSMAGLYTYSNSSDTGIYLY 740
            ..:.....|:.....|:...|.:.:::..: |..:|. :.|....:.|.|     ..::|..:|.
Human   447 PLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCP-VVYCSIVYWMTG-----QPAETSRFLL 505

  Fly   741 MGYMLLYLTLI-QTLALFCAHLLPCKVSASIVNGLISLAVAAVGGYLVHPQNLAQFWSWLQFVSP 804
            ...:.....|: |:|.|...........|:.|..:.::.|....|:.|..:.:..:..|..::|.
Human   506 FSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSY 570

  Fly   805 ERWLLPVLVQDEYSAE 820
            .|:....::...|..|
Human   571 VRYGFEGVILTIYGME 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31121	NP_733058.1	P-loop_NTPase	319..518	CDD:304359	51/206 (25%)
		cbiO	319..491	CDD:130234	44/179 (25%)
		ABC2_membrane	621..809	CDD:279410	30/189 (16%)
ABCG4	NP_001135977.1	3a01204	44..646	CDD:273361	123/613 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830