DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31121 and CG5853

DIOPT Version :9

Sequence 1:	NP_733058.1	Gene:	CG31121 / 42975	FlyBaseID:	FBgn0051121	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_001260309.1	Gene:	CG5853 / 34322	FlyBaseID:	FBgn0032167	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	156/736 - (21%)
Similarity:	280/736 - (38%)	Gaps:	170/736 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 DGG--GGGMGYDYNE---ARLYGSSR-QYGNG------------------------NGHNPGSRK 297
            |.|  |.|:|.:..|   :|:|.|:. ..||.                        ||:.|.  |
  Fly    13 DNGVAGLGLGIEIGEVTSSRVYNSTTVPVGNSGGWRNAQSSVTPPPIPTPPQVNYTNGNEPS--K 75

  Fly   298 QSGMGLIYPNIQVH----CLDVNPCLRGVSMQAK--------------------------AGDLF 332
            |..:..:... :||    .|:..|....|.|:.|                          ...|.
  Fly    76 QPPLEPVVEE-EVHFDTDALNNLPAREPVDMEFKELSLTVKLGFNRGSKEILHNVCGKFPGSQLI 139

  Fly   333 AIMATSQREGSALAECLAGL-TERLGGEILINGQQVSRRGLRELCSYVPALEVSSLDPRMSVQCT 396
            |||..|....|.|.:.|:|. |..:.|.||:||::......|.:..|:  .:...|.|.::|...
  Fly   140 AIMGPSGAGKSTLLDALSGFKTTGVDGSILLNGRRRDLPSFRRMSCYI--TQDDRLQPLLTVNEN 202

  Fly   397 LNFHAALR--GPIDRSDLEERMDVLIEDLGLNTVRASNVSTLTHSEKQRLSVACQLLAQSSLLIL 459
            ::..|.|:  ..:...:.|.|::.::..|||.....:....|:..:|:|||:|.:|:...:::.|
  Fly   203 MHIAADLKLGQTVSYEEKESRIEDILLLLGLYNHDQTLTMRLSGGQKKRLSIAMELINNPTVMFL 267

  Fly   460 DQVTSNMDIFDTFFLVEYLRQWCSGGRIVIMTLQPPTFEILSMCSGVLLLSGGRTVFSGSRADLP 524
            |:.|:.:|......::|.|::..|.||.:|.|:..||.::..:...|.:||.|..|:.||...|.
  Fly   268 DEPTTGLDSSSCTKVLELLKKLTSQGRTIICTIHQPTAKLFQIFDQVYVLSAGNCVYQGSTQKLV 332

  Fly   525 RHMGELGYPCPPFKNPADYYLDLV-------TLDDLSAAAMLESSARIESLANAWDQINSEPPLA 582
            ..:..:..|||.:.|||||.::|.       .:|.|..|.  |:.:.:....|....:.:|..:.
  Fly   333 PFLQSVDLPCPMYHNPADYIIELACGEYGYDKVDTLKLAT--ENGSCLTWFHNPSAVLRAEVLMR 395

  Fly   583 APPASLPNFTMK-----AGFFGQISALIKRFAGYKQPGSLLTWISKLIAAAVLSLFIGCIFWDVP 642
            ..|  :|..|..     ..:..|.|.|::|.....:..:.:|.:...:..||.:|| |.::
  Fly   396 KYP--IPKKTKSRSLEDTSYSNQCSVLLRRGFIKAKRDTTMTHLRIGVNIAVAALF-GAMY---- 453

  Fly   643 ASDPQLSYHDRLG---------YHHCVMVLVYWPL--VMLTIRDTQED-----RRHAERDIRLGL 691
                     |..|         |:....:|::..:  :|||:.....|     :.|..|     .
  Fly   454 ---------DHTGREGSRVLDNYNLLFAILMHHSMTTMMLTVLTFPMDISILIKEHFNR-----W 504

  Fly   692 YTRSLYIIVQSLLGLFPSL--CIWLAYLLPAHSMAGLYTYSNSSDTGIYLYMGYMLLYLTLIQTL 754
            |:...|....:|:.|..|:  |.:...:        :|.:|......|..:|.:.:..||
  Fly   505 YSLKAYYTAMTLVDLPISIISCFFFTVI--------VYLWSYQPMEWIRFFMFFSISLLT----- 556

  Fly   755 ALFCAHLLPCKVSA--SIVNG-----LISLAVAAVGGYLVHPQNLAQFWSWLQFVSPERWLLPVL 812
             :|..|.....:.|  .:|||     ::::.:....|:.|..::|..:..|...:|..|:.|...
  Fly   557 -VFVGHSFGLMIGAWFDVVNGTFLAPVLTIPMMMFAGFGVTLRDLPSYLRWGSHISYLRYGLEGF 620

  Fly   813 VQDEYSAETLSNSAGLQLCRNKQVQHQEIIVQQPCPPPNGTQVLVDFELLPQQHVLDPTPTYDQT 877
            :...|..:     .|...|......|..                     .|::.:.:.|...||.
  Fly   621 ISAIYGLD-----RGTLACEEAPYCHYR---------------------YPKKFLEEITMRGDQF 659

  Fly   878 TSVALVLG-SVLVF-CVTFIV 896
            .:..:.|| .:||| .|:::|
  Fly   660 WNDVIALGVMILVFRFVSYVV 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31121	NP_733058.1	P-loop_NTPase	319..518	CDD:304359	55/227 (24%)
		cbiO	319..491	CDD:130234	47/200 (24%)
		ABC2_membrane	621..809	CDD:279410	39/212 (18%)
CG5853	NP_001260309.1	3a01204	97..689	CDD:273361	137/649 (21%)
		ABCG_EPDR	102..326	CDD:213180	55/225 (24%)
		ABC2_membrane	420..623	CDD:279410	43/235 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48041
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920