DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31121 and abcx-1

DIOPT Version :9

Sequence 1:	NP_733058.1	Gene:	CG31121 / 42975	FlyBaseID:	FBgn0051121	Length:	911	Species:	Drosophila melanogaster
Sequence 2:	NP_495321.3	Gene:	abcx-1 / 183860	WormBaseID:	WBGene00006522	Length:	710	Species:	Caenorhabditis elegans

Alignment Length:	719	Identity:	173/719 - (24%)
Similarity:	307/719 - (42%)	Gaps:	143/719 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 YGNGNGHNPGSRKQSGMGLI---------------YPNIQVHCLDVNPCLR-------------- 320
            :.:...||..:.|:   |:|               |||:.::.|..:..||
Worm    36 FADMQNHNTQNEKK---GIIRYLEYYEINSQSTRPYPNLLLNKLSFSKDLRSSSDKVLLRLPVLK 97

  Fly   321 ----GVSMQAKAGDLFAIMATSQREGSALAECLAGLTE---RLGGEILINGQQVSRRGLRELCSY 378
                .:|.:..:.|:.|||.|.:.|..:|.:.:.|:.:   :|.|:||:||.::||..|.:...:
Worm    98 QEVHNISFELSSSDVLAIMYTKESETISLLKIICGIKDVRGKLSGDILVNGHRMSRDRLEKTIGF 162

  Fly   379 VPALEVSSLDPRMSVQCTLNFHAALRGPIDRSDLEER-------MDVLIEDLGLNTVRASNVSTL 436
            |   .:.|....:||:..|:.|.....|     :.||       ::.|:.||||..|.....|.|
Worm   163 V---SLESPTSTLSVRQYLHVHGNFYPP-----MTERYGGVGHLINKLMTDLGLFPVSDIICSRL 219

  Fly   437 THSEKQRLSVACQLLAQSSLLILDQVTSNMDIFDTFFLVEYLRQWC-SGGRIVIMTLQPPTFEIL 500
            ..|:.||:.||.||:...::|:...:..::|:.|..||::|||:|. ...|||||.:.|.:.:||
Worm   220 NRSQWQRVKVASQLVRDPTILVCSDIFKDIDVHDQCFLIDYLREWAVKTNRIVIMAISPTSLQIL 284

  Fly   501 SMCSGVLLLSGGRTVFSGSRADLPRHMGELGYPCPPFKNPADYYLDLVTLDDLSAAAMLESSARI 565
            :|.|..::|:.||.::.|....:.::...:|.||||:||..|||:||||.|:|::.|..|||.||
Worm   285 NMFSKAMILASGRMIYFGPPKSMQQYFETIGCPCPPYKNVCDYYVDLVTHDNLTSDASRESSVRI 349

  Fly   566 ESLANAWDQINSEPPLAAPPA----------SLPNFTMKAGFFGQISALIKRFAGYKQPGSLLTW 620
            ..|.|.|:|       .|||.          .||.    ||.|..:..||..|           |
Worm   350 ARLVNKWNQ-------TAPPVRRTASGKFLLDLPT----AGIFMNLLTLISLF-----------W 392

  Fly   621 ISKLIAAAVLSLFIGCIF-----WDVPASDPQLSYHDR-LGYHHCVMVLVYWPLVMLTIRDTQE- 678
            .:.:...|....|:..||     ..:..||..|:..|. |..:..:.:|:::..:.:.:.:.::
Worm   393 FNFINNRASRIFFLLFIFSLSTCLSLHLSDLSLTLPDAFLNRNSYLELLIFYVPLFIGLVNLKKC 457

  Fly   679 --------------DRRHAERDIRLGLYTR---SLYIIVQSLLGLFPSLCIW-LAYLLPAHSMAG 725
                          .|.|.:..::|.....   ||.||:.|.:...|.|.|. :.:.:|......
Worm   458 TFLSEFDKFYLFISARHHLKELLKLSPLKNMCSSLSIIIVSFVVELPFLLITSMVFAMPMSIFTD 522

  Fly   726 LYTYSNSSDTGIYLYMGYMLLYLTLIQTLALFCAHLLPCKVS-ASIVNGLISLAVAAVGGYLVHP 789
            .:..|::..|.:........:.|::.|.:....::|....:| ...|....||..|....:.:|
Worm   523 FHQKSSNHLTSLVSISSSFFINLSVTQLVVNSVSNLSSEPLSFFFFVISWFSLFFACGFPFPIH- 586

  Fly   790 QNLAQFWSWLQFVSPERWLLPVLVQDE---YSAETLSNSAGLQL--CRNKQVQHQEIIVQQPCPP 849
             ::.::::.|.|  |...:...|.:|.   |...:::.|..:||  | .:...:...:.:.||
Worm   587 -SILKYFNPLFF--PTTSVFRFLYEDSPSLYPQLSVNLSTPIQLYSC-GRTFLNTTQVTRGPC-- 645

  Fly   850 PNGTQVLVDFELLPQQHVLDPTPTYDQTTSV--ALVLG---------SVLVFCVTFIVFLCNCRG 903
                |.:..||||.....   ..::|:..|:  .:::.         |:|:..|:.::|..|...
Worm   646 ----QKVSSFELLSYYGF---NESFDKQKSIFHGILISNFIFNYLFFSILILFVSCVLFHFNRDK 703

  Fly   904 ACRR 907
            ..||
Worm   704 LIRR 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31121	NP_733058.1	P-loop_NTPase	319..518	CDD:304359	66/227 (29%)
		cbiO	319..491	CDD:130234	57/200 (29%)
		ABC2_membrane	621..809	CDD:279410	36/213 (17%)
abcx-1	NP_495321.3	P-loop_NTPase	102..302	CDD:304359	64/207 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0061
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1022017at2759
OrthoFinder	1	1.000	-	-		FOG0016648
OrthoInspector	1	1.000	-	-		oto18208
orthoMCL	1	0.900	-	-		OOG6_119452
Panther	1	1.100	-	-	O	PTHR48041
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16951
SonicParanoid	1	1.000	-	-		X13515
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.780