DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11089 and ade10

DIOPT Version :9

Sequence 1:	NP_001189286.1	Gene:	CG11089 / 42973	FlyBaseID:	FBgn0039241	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_588027.1	Gene:	ade10 / 2539569	PomBaseID:	SPCPB16A4.03c	Length:	585	Species:	Schizosaccharomyces pombe

Alignment Length:	589	Identity:	352/589 - (59%)
Similarity:	427/589 - (72%)	Gaps:	11/589 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALLSVSDKTGLLDLGKSLVALGFDLVASGGTATSLRGAGLKVRDVSEITGAPEMLGGRVKTLHPA 71
            |||||.||||||:|.|:|.:.|..|:.|||||..:|.:|::|.|||.||.|||:|||||||||||
pombe     3 ALLSVYDKTGLLELAKALTSKGVKLLGSGGTAKMIRESGMEVADVSSITNAPEILGGRVKTLHPA 67

  Fly    72 VHAGILSRTTDSDLADMRKQGFDLIQLVVCNLYPFASTVAKPDVTLADAVENIDIGGVTLLRAAA 136
            ||.|||:|...||..|:.:|..:.|.:||||||||..|:|||:||:.:|||.|||||||||||||
pombe    68 VHGGILARDIPSDEKDLVEQSIEKIDIVVCNLYPFRETIAKPNVTIPEAVEEIDIGGVTLLRAAA 132

  Fly   137 KNHQRVTVVCEAVDY----DRVLSELKASGNTTVETRQALALKAFTHTATYDDAISDYFRKQYGS 197
            |||.|||::.:..||    |:.||:     ..|.:.|...|||||..||:||.||:|||||||.:
pombe   133 KNHARVTILSDPADYATFTDKFLSD-----KLTQDDRNTYALKAFASTASYDAAITDYFRKQYAA 192

  Fly   198 GVSQLPLRYGMNPHQKPAQLYTQLAKLPLTVLNASPGFINLCDALNGWQLVRELKKALQLPAATS 262
            ||.||.||||.||||.|||.:.:...||..||..|||:|||.||||.|.||:||::.:.:|||.|
pombe   193 GVDQLTLRYGANPHQSPAQAFMEQGPLPFKVLCGSPGYINLMDALNSWPLVKELRENIGIPAAAS 257

  Fly   263 FKHVSPAGAAVGVPLNPAQAKLCMVDDLYEQLTPLATAYARARGADRMSSFGDFVALSDVCDVVT 327
            ||||||||||||:||:..:.|:..|.|:.| .||||.|||||||||||||||||:||||..||.|
pombe   258 FKHVSPAGAAVGLPLSDVEKKVYFVSDITE-FTPLACAYARARGADRMSSFGDFIALSDTVDVCT 321

  Fly   328 ARIISREVSDGIIAAGYEPEALEILKKKKNGGYCILQMDPNYEPSAVERKTIFGLTLEQKRNDAV 392
            |||||||||||:||.||||||||:|||||.|.||:|||||.|.|:.:|.:.::|::|:|.||.|.
pombe   322 ARIISREVSDGVIAPGYEPEALELLKKKKGGKYCVLQMDPKYVPAEIETRQVYGISLQQHRNHAK 386

  Fly   393 IDASLFSNVVSKRGPLPEVAVRDLIVATIALKYTQSNSVCYARDGQVVGIGAGQQSRIHCTRLAG 457
            ||.|||..||||...||:.|:.||::||.|||||||||||||::|.|||:||||||||||.||||
pombe   387 IDFSLFEKVVSKNKDLPKSALIDLVIATTALKYTQSNSVCYAKNGMVVGLGAGQQSRIHCNRLAG 451

  Fly   458 EKADNWWLRQHPSVAGMKFKAGVKRAEISNAIDNYVNGTV-GKDMPLSQFEGMFDKAPAQLTSEQ 521
            :||||||||.||.|.||:||...||.|.|||||.||...| .:.....|:|..|:..|..||.::
pombe   452 DKADNWWLRHHPKVLGMQFKKSAKRPEKSNAIDLYVLDAVPAEGSEREQWESAFETIPEPLTKKE 516

  Fly   522 KVEWLKQLSGVALGSDAFFPFRDNIDRASLSGVSYIASPAGSTNDAGVIAACDEHGIIMAHTNLR 586
            :.|:|.....|...|||||||.|||.|.:.|||.|:|:|.||..|..|....:|..::.:...||
pombe   517 REEFLATCKDVVCASDAFFPFPDNIYRLAQSGVKYVAAPGGSVMDQAVRDTANEFNMVFSEIPLR 581

  Fly   587 LFHH 590
            ||||
pombe   582 LFHH 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11089	NP_001189286.1	PurH	5..590	CDD:223216	350/587 (60%)
		IMPCH	5..191	CDD:238709	109/187 (58%)
		PRK07106	201..590	CDD:180841	233/389 (60%)
ade10	NP_588027.1	PurH	1..585	CDD:223216	350/587 (60%)
		IMPCH	1..186	CDD:238709	109/187 (58%)
		PRK07106	196..585	CDD:180841	233/389 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	408	1.000	Domainoid score	I93
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2983
Inparanoid	1	1.050	681	1.000	Inparanoid score	I110
OMA	1	1.010	-	-		QHG61841
OrthoFinder	1	1.000	-	-		FOG0003490
OrthoInspector	1	1.000	-	-		oto101096
orthoMCL	1	0.900	-	-		OOG6_101217
Panther	1	1.100	-	-	LDO	PTHR11692
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1037
SonicParanoid	1	1.000	-	-		X2382
TreeFam	0	0.000	Not matched by this tool.
	12	12.000