Protein Alignment CG3744 and Dpp8

DIOPT Version :10

• Sequence 1: NP_733056.3
• Gene: CG3744 / 42972
• FlyBaseID: FBgn0039240
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_083182.2
• Gene: Dpp8 / 74388
• MGIID: 1921638
• Length: 892
• Species: Mus musculus
• Alignment Length: 928
• Identity: 360/928 - (38%)
• Similarity: 510/928 - (54%)
• Gaps: 100/928 - (10%)

  Fly   200 ECDDCEEDEDDPVDNDGHIAAPTPNKSWAENKQVVQEIRKKMCNLSSMVPTNVQF--RHLSDG-- 260
            |..:|||...:..|............||::.|:::.:.||....:.:..|.:..|  |...||
Mouse    25 ETAECEEGNGESQDRPKLEPFYVERYSWSQLKKLLADTRKYHGYMMAKAPHDFMFVKRTDPDGPH 89

  Fly   261 RARCYFLGTPPQSWETTLLFADINLTQSEEQQLLVQRLEGIASDEWSPTMNAGSPTSSGHQPAFL 325
            ..|.|:|....::.|.||.:::|..|.:....|:
Mouse    90 SDRVYYLAMSGENRENTLFYSEIPKTINRAAVLM------------------------------- 123

  Fly   326 FNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAREYQLLQERKRLSTWGITSYELHKPSGKLV 390
                    |.|.|||.. .|::...|      .|:||.:||:||||:.|.||.:|:.|..||..:
Mouse   124 --------LSWKPLLDL-FQATLDYG------MYSREEELLRERKRIGTVGIAAYDYHPGSGTFL 173

  Fly   391 FPCFNDLYQCLD---TGYNSGLLFPTQLRT-CPQWTALDPQICPQNSDMIAYISDCDLFVTHTLS 451
            |...:.:|...|   .|:....|.|..:.| ||. ..:||::||.:.|.||:|...|:::::.::
Mouse   174 FQAGSGIYHIKDGGPHGFTQQPLRPNLVETSCPN-IRMDPKLCPADPDWIAFIHSNDIWISNLVT 237

  Fly   452 GHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEEFSRYQGFWWQPH-----SNDGIYRIVYEEVDE 511
            ..|:|:||......:..:|..||||.::|:||||.||.|:||.|.     |...|.||:|||.||
Mouse   238 REERRITYVHNELANMEEDPRSAGVATFVLQEEFDRYSGYWWCPQAERTPSGGKILRILYEENDE 302

  Fly   512 SEVSVYTFPSSTAMHGRVDEYRFPRTGSPNAKSKLKLVQFVLNEALQVSEIAIKDL--PYSLLAV 574
            |||.:....|......|.|.:|:|:||:.|.|...|:.:.|::.|..:.::..|:|  |:.:|
Mouse   303 SEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIVVDAAGGIIDVIDKELVQPFEIL-- 365

  Fly   575 FSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPLDNFCESYSSQVSTPTDSIGDHSWRSLY 639
            |..:|||.|.||||:.|:.|...|||.|..|.::||         |.::..|.:.......|.:.
Mouse   366 FEGVEYIARAGWTPEGKHAWSILLDRSQTHLQIVLI---------SPELFIPVEDDAMDRQRLIE 421

  Fly   640 S--RTITPLQVIYTERSDSWINVHDMLHFLDLT-ETSVTFLWASE-ETGFRHLYLVTASLLLSQ- 699
            |  .::||| :||.|.:|.|||:||:.|....| |..:.|::||| :|||||||.:|:.|..|:
Mouse   422 SVPDSVTPL-IIYEETTDIWINIHDIFHVFPQTHEDEIEFIFASECKTGFRHLYKITSILKESKY 485

  Fly   700 ---ANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWEVLAR---NLWVDKANKLVYFVGLR 758
               :.|.|.|            |..:..|..::.:||||||||.|   |:|||:|.|||||.|.:
Mouse   486 KRSSGGLPAP------------SDFKCPIKEEITITSGEWEVLGRHGSNIWVDEARKLVYFEGTK 538

  Fly   759 DTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKLMLLVYCNIQRLPSCKVMRVNQTCSNG 823
            |:|||.||||.|...|..:..||:.|||:.......|...:..|.| |:.|.|..:....:..:.
Mouse   539 DSPLEHHLYVTSYANPGEVVRLTDRGYSHSCCLSRHCDFFISKYSN-QKNPHCVSLYKLSSPEDD 602

  Fly   824 GVNGIQISLVGYLHEGGKPEPQYC-PQIFSPQLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGP 887
            .|:..:......|...| |.|.|. |:|||.:..:|..:|.|::|||:.:.|.||||||.:||||
Mouse   603 PVHKTKEFWATILDSAG-PLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGP 666

  Fly   888 EVQTVNNTFKGKHQLRMHMLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSL 952
            :||.|||.|||....|::.||:.||.|:.||:|||.|||.:||...:.:|||:|:.|||:.|:.|
Mouse   667 QVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYL 731

  Fly   953 SDQLGYIDMDRVAIHGWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNN 1017
            :.|..:||:|||.|||||||||||||.|:|...||:|||||||||.|.:||||||||||..|..|
Mouse   732 ASQYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQN 796

  Fly  1018 EAGYSAGSVLEYVNSFPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSL 1082
            |.||..|||......||.|..||||:||.:||||||.|||.|:|.|.:|.|||::.::|:||||:
Mouse   797 EQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQERHSI 861

  Fly  1083 RNLESNKNYETKLLSFLQ 1100
            |..||.::||..||.:||
Mouse   862 RVPESGEHYELHLLHYLQ 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_733056.3	DPPIV_N	419..802	CDD:395744	150/400 (38%)
		Peptidase_S9	902..1101	CDD:459761	115/199 (58%)
Dpp8	NP_083182.2	Dpp_8_9_N	1..156	CDD:466112	40/176 (23%)
		DPPIV_N	169..589	CDD:395744	163/445 (37%)
		Peptidase_S9	681..885	CDD:459761	115/199 (58%)