Protein Alignment CG3744 and DPP10

DIOPT Version :10

• Sequence 1: NP_733056.3
• Gene: CG3744 / 42972
• FlyBaseID: FBgn0039240
• Length: 1102
• Species: Drosophila melanogaster
• Sequence 2: NP_001308834.2
• Gene: DPP10 / 57628
• HGNCID: 20823
• Length: 813
• Species: Homo sapiens
• Alignment Length: 909
• Identity: 209/909 - (22%)
• Similarity: 350/909 - (38%)
• Gaps: 222/909 - (24%)

  Fly   265 YFL------GTPPQ-SWE------------------TTLLFADINLTQSEEQQLLVQ---RLEGI 301
            |||      .:||| :|:                  :.:|.....||.|.|.:|.::   |.:.:
Human    33 YFLVYELGSNSPPQRNWKGIAIALLVILVVCSLITMSVILLTPDELTNSSETRLSLEDLFRKDFV 97

  Fly   302 ASD---EWSPTMNAGSPTSSGHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAREY 363
            ..|   .|....:....:.:||                  :::..|:::..:
Human    98 LHDPEARWINDTDVVYKSENGH------------------VIKLNIETNATT------------- 131

  Fly   364 QLLQERKRLSTWGITSYELHKPSGKLVFPCFNDLYQCLDTGYNSGLLFPTQLRTCPQWTALDPQI 428
             ||.|.....|:..:.:.: .|..|.|...: |:.|.....|.:..:. ..:.|...|....|::
Human   132 -LLLENTTFVTFKASRHSV-SPDLKYVLLAY-DVKQIFHYSYTASYVI-YNIHTREVWELNPPEV 192

  Fly   429 CPQNS-----------DMIAYISDCDLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQ 482
              ::|           ..:.||.:.:::....:.....||  ||:|:    ::.:..|:..::.:
Human   193 --EDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRL--TSSGK----EEIIFNGIADWLYE 249

  Fly   483 EE-FSRYQGFWWQPHSNDGIYRIVYEEVDESEVSVYTFPSST-AMHGRVDEYRFPRTGSPNAKSK 545
            || ...:...||.|   || .|:.:..:::|.|.....|..| |::.:..:|.:|:.|..|...|
Human   250 EELLHSHIAHWWSP---DG-ERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIK 310

  Fly   546 LKLVQFVLNEALQVSEI----AIKDLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLD 606
            |.:|.  |.......|:    :.|...|          ||..|.|..:.|.| |:.|:|.|.
Human   311 LYVVN--LYGPTHTLELMPPDSFKSREY----------YITMVKWVSNTKTV-VRWLNRAQN--- 359

  Fly   607 VILIPLDNFCESYSSQVSTPTDSIGDHSWRS------LYSRTITPLQVIYTERSDSWINVHDMLH 665
               |.:...||:.:...|...:...| :|.|      ::||..:...:....:.......|.:..
Human   360 ---ISILTVCETTTGACSKKYEMTSD-TWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAM 420

  Fly   666 FLDLTETSVTFLWASEETGFRHLYLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVA 730
            ||..::        ||:...||
Human   421 FLIQSK--------SEQITVRH------------------------------------------- 434

  Fly   731 LTSGEWEVLARNLWVDKANKLVYFVGLRDTPLEKHLYVVSLERPEHIRLLTEPGYS--YLVE--- 790
            ||||.|||: :.|..|:..:.:||:....:|..:.||..|.|     .||.....|  ::.|
Human   435 LTSGNWEVI-KILAYDETTQKIYFLSTESSPRGRQLYSASTE-----GLLNRQCISCNFMKEQCT 493

  Fly   791 -FDDQCKLM---LLVYCNIQRLPSCKVMRVNQTCSNGGVNGIQISLVGYLHEG------GKPEPQ 845
             ||.....|   .|::|...|:|   |:.::.|  :.......:.....|.|.      ||||.:
Human   494 YFDASFSPMNQHFLLFCEGPRVP---VVSLHST--DNPAKYFILESNSMLKEAILKKKIGKPEIK 553

  Fly   846 YCPQIFSPQLPSGDIVYAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMH----- 905
            .. .|...:||      ..:..|.:|....:|..:|.:...|..|.|.:.|        |
Human   554 IL-HIDDYELP------LQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKF--------HIDWDS 603

  Fly   906 -MLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGW 969
             ::......|...|.|||..:|.:....|..|:|.||:.||:.|::.|. :|.|||..|::|.|.
Human   604 VLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLL-KLPYIDSKRLSIFGK 667

  Fly   970 SYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDMPQNNEAGYSAGSVLEYVNSFP 1034
            .||||::.|.|....|:||.....||:|:.:.|.:.::|||:.||...|:.|.|.|||..|:...
Human   668 GYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLK 732

  Fly  1035 EEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYETKLLSF 1098
            ||:  :|:|||..|..|||.|::.||..|.||...|.:.::|:|.|::........|.|.|..|
Human   733 EEN--ILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFF 794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_733056.3	DPPIV_N	419..802	CDD:395744	85/414 (21%)
		Peptidase_S9	902..1101	CDD:459761	72/203 (35%)
DPP10	NP_001308834.2	DPPIV_N	150..516	CDD:395744	94/456 (21%)
		Peptidase_S9	597..799	CDD:459761	73/209 (35%)