DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and fap

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_001920834.4	Gene:	fap / 565888	ZFINID:	ZDB-GENE-081104-439	Length:	750	Species:	Danio rerio

Alignment Length:	816	Identity:	203/816 - (24%)
Similarity:	348/816 - (42%)	Gaps:	169/816 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   316 TSSGHQPAFLFNSLPRPRLPWSPLLQQPIQSSGGSGGSGSASPYAREYQLLQERKRLSTWGITSY 380
            |:.||  .:|.|:             :..:||.....|..|...|.:|.|..:||      ..::
Zfish    68 TNEGH--IYLHNA-------------ETKESSVYLSNSTFAQVDATDYILSADRK------FAAF 111

  Fly   381 EL-HKPSGKLVFPCFNDLYQCLDTGYNSGLLFP--TQLRTCPQWTALDPQICPQNSDMIAYISDC 442
            |. :....:..|.....:|......:.|.:..|  |||.|   |..:        .:.:||:.:.
Zfish   112 ESNYSKQWRHSFTASYSIYNVESGEFLSKVQIPHVTQLLT---WAPV--------GNKLAYVWNF 165

  Fly   443 DLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEE-FSRYQGFWWQPHSNDGIYRIVY 506
            ::::..:.:....::|:...|      :.:..|||.:|.:|| |:..:..||.|   .|.| :.|
Zfish   166 NIYLKASATAEAVQVTHNGKG------NEILNGVPDWVYEEEVFASNEAIWWSP---QGKY-LAY 220

  Fly   507 EEVDESEVSVYTFPSSTAMHGRVDEY------RFPRTGSPNAKSKLKLVQFVLNEALQVSEIAIK 565
            .:|:::.|....:    :::|. |:|      .:|:.||...:::|.::. |.|.:.| ||:.:
Zfish   221 LQVNDTGVHSIEY----SLYGN-DQYPVTVFVPYPKAGSVIPRARLFVID-VENPSRQ-SEVVV- 277

  Fly   566 DLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVILIPLDNFCESYSSQVSTPTDSI 630
              |.|   |.|...|:..|.|..|.:.. ||.:.|:|   |.:|:.:.:: :....:.||..:..
Zfish   278 --PKS---VGSGDHYLSTVTWVTDDRLA-VQWMPRRQ---DSVLLQIYDY-DGTKWKESTKFEQK 332

  Fly   631 GDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFLDLTETSVTFLWASEETGFRHLYLVTASL 695
            ....|...|    .|....:...:.|:..|                  .|.:.|::||:.|.|
Zfish   333 SKTGWVGRY----FPSAPYFAANNMSFYKV------------------MSNDNGYKHLHYVNA-- 373

  Fly   696 LLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVALTSGEWEVLARNLWVDKANK-LVYFVGLRD 759
                  |:..|                        :|||:|||    :::.|..| .:|:|....
Zfish   374 ------GKATP------------------------ITSGKWEV----IYISKVTKDSIYYVSNEH 404

  Fly   760 --TPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKLMLLVY----------CNIQRLPSCK 812
              .|.:::||.:|:....|    :.|.......::|:|:.....:          |....||...
Zfish   405 MARPGQRNLYKISISSSGH----SAPKCLTCALYEDRCQYNSAYFSLNASYFRMDCYGPGLPLFT 465

  Fly   813 VMRVNQTCSNGGVNGIQISLVGYLHEGGKPEPQYCPQIFSPQLPSG-------DIVYAMVFKPHN 870
            :|.     :.|.....|:     |.:..|.|.....::..|....|       |:.|.|:|.| |
Zfish   466 MMD-----NRGPAKETQV-----LEDNKKLENILTTELLMPTKKRGTLKIAGFDLWYQMMFPP-N 519

  Fly   871 FELGVKYPTVLNVYGGPEVQTVNNTFKGKHQLRMHMLAAQGYCVICIDSRGSRHRGKRFESHIRG 935
            |:...|||.:::|||||..|.::..|  :.:...::.:.:...|...|.|||..:|......|..
Zfish   520 FDSSKKYPLLIDVYGGPASQNIDYVF--RLEWATYLCSTERIIVASFDGRGSGFQGDEIMHAIYE 582

  Fly   936 RMGQVELTDQVDALRSLSDQLGYIDMDRVAIHGWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWE 1000
            |:|..|:.||:.|:|... ::|:||.||:|:.|||||||::.|.|.....:||..||.|||..||
Zfish   583 RLGTYEVEDQITAVRKFI-EMGFIDKDRIAMWGWSYGGYVTSMALGSGSGLFKCGIAVAPVAKWE 646

  Fly  1001 YYDTGYTERYMDMPQNNEAGYSAGSVLEYVNSFPEEDKRLLLIHGLIDENVHFCHTSRLISALNK 1065
            |||..||||||..||:|...|...:|.:...:|  :..:.||:||..|:||||...:::..||.:
Zfish   647 YYDAVYTERYMHRPQDNFESYKNSTVTDRAKNF--KSVQYLLVHGTADDNVHFQQAAQISKALVE 709

  Fly  1066 ANKPYEVHLFPEERHSLRNLESNKNYETKLLSFLQN 1101
            ....:|...:.::.|||.. ::..:..|.|..||:|
Zfish   710 NQVDFEAMWYTDKDHSLSG-KARYHLYTHLNHFLKN 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	79/392 (20%)
		DAP2	<838..1099	CDD:224423	91/267 (34%)
		Peptidase_S9	902..1101	CDD:278741	72/198 (36%)
fap	XP_001920834.4	DPPIV_N	103..462	CDD:279298	91/465 (20%)
		FrsA	492..740	CDD:223999	89/254 (35%)
		Peptidase_S9	549..746	CDD:278741	73/200 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574442
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840