DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3744 and dpp4

DIOPT Version :9

Sequence 1:	NP_001262935.1	Gene:	CG3744 / 42972	FlyBaseID:	FBgn0039240	Length:	1102	Species:	Drosophila melanogaster
Sequence 2:	XP_012825865.2	Gene:	dpp4 / 548987	XenbaseID:	XB-GENE-976654	Length:	810	Species:	Xenopus tropicalis

Alignment Length:	787	Identity:	191/787 - (24%)
Similarity:	323/787 - (41%)	Gaps:	194/787 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 REYQLLQERKRLSTWGITSYELHKPSGKLVFPCFNDLYQCLDTGYN---SGLLFPTQLRTCPQWT 422
            |.|.|||          .:||      ||....:...|...||...   :..:.|.|:    |:.
Frog   165 RNYALLQ----------YNYE------KLWRHSYTASYHIYDTVKGEIVTANVLPNQI----QYI 209

  Fly   423 ALDPQICPQNSDMIAYISDCDLFVTHTLSGHEKRLTYTSTGRHSYVDDALSAGVPSYVMQEE-FS 486
            ...|.     .:.:||:.:.::::..|..|  ..:..|:.|.|:.:.:    |:|.:|.:|| ||
Frog   210 TWSPV-----GNKLAYVWENNIYIKETPGG--SSIQITTNGEHNKILN----GIPDWVYEEEMFS 263

  Fly   487 RYQGFWWQPHSNDGIYRIVYEEVDESEVSV--YTFPSSTAMHGRVDEY------RFPRTGSPNAK 543
            .....||.|.:..    :.|.|.::::|..  |:|....:     |:|      .:|:.|:.|..
Frog   264 TNYALWWSPDAAS----LAYVEFNDTDVPAIEYSFYGEDS-----DQYPKTVVIPYPKAGAKNPT 319

  Fly   544 SKLKLVQFVLNEALQVSEIAIKDLPYSLLAVFSWLEYIVRVGWTPDAKYVWVQGLDRKQQRLDVI 608
            .:|    ||:|.|...:..:::..|.:.|....:  ||..:.|..:.|.. ||.|.|.|   :|.
Frog   320 VRL----FVVNTASLPAFNSVEIPPPAELRTIDY--YINGMNWVTNGKMA-VQWLRRIQ---NVS 374

  Fly   609 LIPLDNF------CESYSSQVSTPTDSIGDHSWRSLYSRTITPLQVIYTERSDSWINVHDMLHFL 667
            |:.:.:|      |:....:.||.       .|...:.    |....:|:....:..|
Frog   375 LLTVCDFAAPAWNCQPPVYEQSTT-------GWVGYFQ----PSSPYFTQDGQKYYKV------- 421

  Fly   668 DLTETSVTFLWASEETGFRHLYLVTASLLLSQANGQPDPGSVGAQPSFVDLSALQPRILNKVALT 732
                       .|.:.||:|::|.         .|..:|                      ||:|
Frog   422 -----------ISNKEGFKHIHLF---------EGAKEP----------------------VAIT 444

  Fly   733 SGEWEVLARNLWVDKANKLVYFVGLRDTPLEKHLYVVSLERPEHIRLLTEPGYSYLVEFDDQCKL 797
            ||:|||.:   ....|:.|:|::.....|..:.||.:.|:...:               ..||
Frog   445 SGKWEVTS---ITTVASNLLYYISNEGFPGRRQLYKIRLDGGSN---------------SAQC-- 489

  Fly   798 MLLVYCNIQRLPSC-----------KVMRVNQTCSNGGV---------NGIQISLVGYLHEGGKP 842
               |.||| |...|           |...:|  |:..||         |..::    ::.|..:.
Frog   490 ---VTCNI-RQERCQQYSAYFSKDSKYYALN--CNGPGVPIYTLYNSSNDKEM----HIMEDNEE 544

  Fly   843 EPQYCPQIFSPQLPSGDIV-------YAMVFKPHNFELGVKYPTVLNVYGGPEVQTVNNTFKGKH 900
            ......::..|...:..|:       |.:...| ||:...|||.:::|||||..|.|:..|  :.
Frog   545 LKLLLDEVQMPTKENKSIIIDGFELWYQLTLPP-NFDKSKKYPLLIDVYGGPCSQKVDQYF--RL 606

  Fly   901 QLRMHMLAAQGYCVICIDSRGSRHRGKRFESHIRGRMGQVELTDQVDALRSLSDQLGYIDMDRVA 965
            ....::.:.:...|...|.|||.::|.:....:..::|.:|:.||:.|.|... .||::|..|:|
Frog   607 NWATYLASTEKIIVASFDGRGSGYQGDKIMHQLYHKLGTLEVQDQIAAARYFI-TLGFVDPKRIA 670

  Fly   966 IHGWSYGGYLSLMGLVQYPKIFKVAIAGAPVTNWEYYDTGYTERYMDM--PQNNEAGYSAGSVLE 1028
            |.|||||||::.|.|.....:||..||.|||::|||||:.||||||.:  |::|...|.:.:|:.
Frog   671 IWGWSYGGYVTSMVLGSGSGLFKCGIAVAPVSSWEYYDSIYTERYMGLPTPEDNLENYLSSTVMA 735

  Fly  1029 YVNSFPEEDKRLLLIHGLIDENVHFCHTSRLISALNKANKPYEVHLFPEERHSLRNLESNKNYET 1093
            ....|  :|...|||||..|:||||...:.:..||..|...::...:.::.|.:.. .:|::..|
Frog   736 RAQKF--KDVEYLLIHGTADDNVHFQQAAHISKALVDAQVDFDTMWYTDKDHGIGG-TANRHIYT 797

  Fly  1094 KLLSFLQ 1100
            .:..:|:
Frog   798 HMSHYLK 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3744	NP_001262935.1	DPPIV_N	419..802	CDD:279298	79/397 (20%)
		DAP2	<838..1099	CDD:224423	85/269 (32%)
		Peptidase_S9	902..1101	CDD:278741	68/201 (34%)
dpp4	XP_012825865.2	DPPIV_rep	94..114	CDD:408582
		DPPIV_N	162..524	CDD:395744	104/494 (21%)
		Peptidase_S9	604..810	CDD:395257	69/207 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910